Antimicrobial activity of the bufadienolides marinobufagin and telocinobufagin isolated as major components from skin secretion of the toad Bufo rubescens

Toxicon

Volumn 45, Issue 6, 2005, Pages 777-782

  Cunha Filho, Geraldino A ^a   Schwartz, Carlos Alberto ^a   Resck, Inês S ^a   Murta, Maria Márcia ^a   Lemos, Sebastião S ^a   Castro, Mariana S ^a   Kyaw, Cynthia ^a   Pires Jr , Osmindo R ^a   Leite, José Roberto S ^b   Bloch Jr , Carlos ^b   Schwartz, Elisabeth Ferroni ^a  

^a UNIVERSITY OF BRASILIA   (Brazil)

^b EMBRAPA RECURSOS GENÉTICOS E BIOTECNOLOGIA   (Brazil)

Author keywords

Amphibian; Antimicrobial; Bufadienolides; Bufo rubescens; Skin secretion; Venom

Indexed keywords

AMOXICILLIN; BUFADIENOLIDE DERIVATIVE; IMIPENEM; MARINOBUFAGIN; TELOCINOBUFAGIN; TRIMETHOPRIM; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ANTIBIOTIC SENSITIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL GROWTH; BRAZIL; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG ISOLATION; ELECTROSTIMULATION; ESCHERICHIA COLI; EXTRACTION; GROWTH INHIBITION; HEART VENTRICLE CONTRACTION; MASS SPECTROMETRY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; PURIFICATION; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SKIN SECRETION; STAPHYLOCOCCUS AUREUS; STRUCTURE ANALYSIS; TISSUE SECTION; TOAD;

EID: 20144389436     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxicon.2005.01.017     Document Type: Article

References (29)

1. T. Akizawa, T. Mukay, M. Matsukawa, M. Yoshioka, J.F. Morris, and V.P. Butler Jr. Structures of novel bufadienolides in the eggs of a toad, Bufo marinus Chem. Pharm. Bull. 42 3 1994 754 756
2. +-ATPase inhibitor in patients after acute myocardial infarction Hypertension 31 1998 1097 1103
3. +-ATPase blocking Life Sci. 72 2002 699 709
4. H.G. Boman Peptide antibiotics and their role in innate immunity Annu. Rev. Immunol. 13 1995 61 92
5. B.T. Clark The natural history of amphibian skin secretions their normal functioning and potential medical applications Biol. Rev. 72 1997 365 379
6. J.M. Conlon, J. Kolodziejek, and N. Nowotny Antimicrobial peptides from ranid frogs: taxonomic and phylogenetic markers and a potential source of new therapeutic agents Biochem. Biophys. Acta 1696 2004 1 14
7. P.A. Doris, and A.Y. Bagrov Endogenous sodium pump inhibitors and blood pressure regulation: an update on recent progress (44283) Proc. Soc. Exp. Biol. Med. 218 1998 156 167
8. R.E. Hancock, and D.S. Chapple Peptide antibiotics Antimicrob. Agents Chemother. 43 1999 1317 1323
9. Y. Jing, H. Ohizumi, N. Kawazoe, S. Hashimoto, Y. Masuda, S. Nakajo, T. Yoshida, Y. Kuroiwa, and K. Nakaya Selective inhibitory effect of bufalin and growth of human tumor cells in vitro: association with the induction of apoptosis in Leukemia HL-60 cells J. Cancer Res. 85 1994 645 651
10. Y. Kamano, A. Kotake, H. Hashima, M. Inoue, H. Morita, K. Takeya, H. Itokawa, N. Nandachi, T. Segawa, A. Yukita, K. Saitou, M. Katsuyama, and G.R. Pettit Structure-cytotoxic activity relationship for the toad poison bufadienolides Bioorg. Med. Chem. 6 1998 1103 1115
11. Y. Kamano, A. Yamashita, T. Nogawa, H. Morita, K. Takeya, H. Itokawa, T. Segawa, A. Yukita, K. Saito, M. Katsuyama, and G.R. Pettit QSAR evaluation of the Ch'an Su and related bufadienolides against the colchicine-resistant primary liver carcinoma cell line PLC/PRF/5 J. Med. Chem. 45 2002 5440 5447
12. H.-S. Kim, B.-S. Choi, K.-C. Kwon, S.-O. Lee, H.J. Kwak, and C.H. Lee Synthesis and antimicrobial activity of squalamine analogue Bioorg. Med. Chem. 8 2000 2059 2065
13. Krenn, L., Kopp, B., 1998. Bufadienolides from animal and plant sources. Phytochemistry 48, 1-29.
14. D.Y. Lee, and H.J. Yoon Growth-inhibiting effect of bufadienolides on cultured vascular endothelial cells Korean J. Toxicol. 11 1995 175 180
15. Y. Meng, P. Whiting, V. Sik, H.H. Rees, and L. Dinan Ecdiesteroids and bufadienolides from Helleborus torquatus (Ranunculaceae) Phytochemistry 47 2001 402 407
16. T. Nakanishi, H. Nishino, E. Ichiishi, T. Mukainaka, M. Okuda, and H. Tokuda Inhibitory effects of bufadienolides on Epstein-Barr virus early antigen activation and on growth of mouse skin and mouse pulmonary tumors Nat. Med. 53 1999 324 328
17. T. Nogawa, Y. Kamano, A. Yamashita, and G.R. Pettit Isolation and structure of five mew cancer cell growth inhibitory bufadienolides from the Chinese tradicional drug Ch'an su J. Nat. Prod. 64 2001 1148 1152
18. C.B. Park, M.S. Kim, and S.C. Kim Mechanism of action of the antimicrobial peptide buforin II: buforin II kills microorganisms by penetrating the cell membrane and inhibiting cellular functions Biochem. Biophys. Res. Commun. 218 1996 408 413
19. A.S. Riera, A. Daud, A. Gallo, S. Genta, M.A. Ybar, and S. Sánchez Antibacterial activity of lactose-binding lectins from Bufo arenarum skin Biocell 27 1 2003 37 46
20. W. Schoner Endogenous cardiac glycosides, a new class of steroid hormones Eur. J. Biochem. 269 2002 2440 2448
21. E.N. Schwartz, C.A. Schwartz, A. Sebben, S.W. Largura, and E.G. Mendes Indirect cardiotoxic activity of the caecilian Siphonops paulensis (Gymnophiona, Amphibia) skin secretion Toxicon 37 1 1999 47 54
22. K. Shimada, Y. Fujii, E. Yamashita, Y. Niizaki, Y. Sato, and T. Nambara Studies on cardiotonic steroids from the skin of Japanese toad Chem. Pharm. Bull. 25 1977 714 730
23. M. Simmaco, G. Mignogna, and D. Barra Antimicrobial peptides from amphibian skin: what do they tell us? Biopolymers 47 6 1998 435 450
24. P.S. Steyn, and F.R. Heerden Bufadienolides of plant and animal origin Nat. Prod. Rep. 15 4 1998 397 413
25. U. Supratman, T. Fujita, K. Akiyama, and H. Hayashi Inseticidal compounds from Kalanchoe daigremontiana×tubiflora Phytochemistry 58 2001 311 314
26. M. Taniguchi, and I. Kubo Ethnobotanical drug discovery based on medicine men's trials in the African savanna: screening of east African plants for antimicrobial activity II J. Nat. Prod. 56 9 1993 1539 1546
27. R. Verpoorte, P.-Q. Kinh, and A.B. Svendsen Chemical constituents of vietnamese toad venom, collected from Bufo melanostictus Schneider. Part II. The bufadienolides J. Nat. Prod. 43 1980 347 352
28. M. Zasloff Antimicrobial peptides in health and disease N. Engl. J. Med. 347 2002 1199 1200
29. R. Zelnick, L.M. Ziti, and C.V. Guimarães A chromatographic study of the bufadienolides isolated from the venom of the parotoid glands of Bufo paracnemis Lutz 1925 J. Chromatogr. 15 1964 9 14