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Volumn 82, Issue 6, 2005, Pages 934-935

Formation of α-tetralone by intramolecular Friedel-Crafts acylation

Author keywords

[No Author keywords available]

Indexed keywords

DRUG PRODUCTS; MOLECULAR STRUCTURE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; ORGANIC ACIDS;

EID: 20144384415     PISSN: 00219584     EISSN: None     Source Type: Journal    
DOI: 10.1021/ed082p934     Document Type: Article
Times cited : (9)

References (13)
  • 4
    • 0003574131 scopus 로고
    • 3rd ed.; Grayson, M., Ed.; John Wiley and Sons: New York
    • Kirk-Othmer Encyclopedia of Chemical Technology, 3rd ed.; Grayson, M., Ed.; John Wiley and Sons: New York, 1981; Vol. 19, pp 732-733.
    • (1981) Kirk-Othmer Encyclopedia of Chemical Technology , vol.19 , pp. 732-733
  • 5
    • 20144375931 scopus 로고
    • The Pfitzinger is an old synthesis of quinoline-4-carboxylic acids from the reaction of isatin and α-methylene carbonyl compounds. The conditions are harsh: a concentrated solution of hydroxide in aqueous alcohol, isatin, and the α-methylene carbonyl compound are heated at reflux for several days. The mixture is treated with charcoal, filtered, and the product is precipitated by acidification with 50% acetic acid. For examples, see Baldwin, J. E.; Magnus, P. E., Eds.; Tetrahedron Organic Chemistry Series, Elsevier: Oxford, United Kingdom
    • The Pfitzinger is an old synthesis of quinoline-4-carboxylic acids from the reaction of isatin and α-methylene carbonyl compounds. The conditions are harsh: a concentrated solution of hydroxide in aqueous alcohol, isatin, and the α-methylene carbonyl compound are heated at reflux for several days. The mixture is treated with charcoal, filtered, and the product is precipitated by acidification with 50% acetic acid. For examples, see Hassner, A.; Stumer, C. In Organic Syntheses Based on Name Reactions and Unnamed Reactions; Baldwin, J. E.; Magnus, P. E., Eds.; Tetrahedron Organic Chemistry Series, Elsevier: Oxford, United Kingdom, 1994; Vol. 11, p 297.
    • (1994) Organic Syntheses Based on Name Reactions and Unnamed Reactions , vol.11 , pp. 297
    • Hassner, A.1    Stumer, C.2
  • 10
    • 2842521754 scopus 로고
    • Horning, E. C., Ed.; John Wiley and Sons: New York
    • Snyder, H. R.; Werber, F. X. In Org, Syntheses, Collective Volume III, Horning, E. C., Ed.; John Wiley and Sons: New York, 1955; pp 798-800.
    • (1955) Org, Syntheses, Collective , vol.3 , pp. 798-800
    • Snyder, H.R.1    Werber, F.X.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.