Effect of vitamin E and polyphenols on ochratoxin A-induced cytotoxicity in liver (HepG2) cells

Journal of Plant Physiology

Volumn 162, Issue 7, 2005, Pages 818-822

  Hundhausen, Christoph ^a   Bösch Saadatmandi, Christine ^a   Augustin, Kay ^a   Blank, Ralf ^a   Wolffram, Siegfried ^a   Rimbach, Gerald ^a  

^a UNIVERSITY OF KIEL   (Germany)

Author keywords

Antioxidants; Flavonoids; Glutathione; Ochratoxin A; Oxidative stress; Tocopherol

Indexed keywords

BIOASSAY; BIOLOGICAL ORGANS; CELLS; CONCENTRATION (PROCESS); PHENOLS; TOXIC MATERIALS;

CATECHIN (CAT); DAIDZEIN (DAI); OXIDATIVE DAMAGE; TOXIC EFFECTS;

VITAMINS;

BIOLOGICAL TESTS; CELLS; CONCENTRATION; PHENOLS; TOXICITY; VITAMINS;

FELIS CATUS;

EID: 20144384125     PISSN: 01761617     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jplph.2005.04.021     Document Type: Conference Paper

References (23)

1. A. Baldi, M.N. Losio, F. Cheli, R. Rebucci, L. Sangalli, E. Fusi, B. Bertasi, E. Pavoni, S. Carli, and I. Politis Evaluation of the protective effects of α-tocopherol and retinol against ochratoxin A cytotoxicity Br J Nutr 91 2004 507 512
2. I. Baudrimont, A.M. Betbeder, A. Gharbi, G. Pfohl-Leszkowicz, G. Dirheimer, and E.E. Creppi Effect of superoxide dismutase and catalase on the nephrotoxicity induced by subchronical administration of ochratoxin A in rats Toxicology 89 1994 101 111
3. I. Baudrimont, A.M. Betbeder, and E.E. Creppi Reduction of the ochratoxin A-induced cytotoxicity in Vero cells by aspartame Arch Toxicol 71 5 1997 290 298
4. A. Belmadani, P.S. Steyn, G. Tramu, A.M. Betbeder, I. Baudrimont, and E.E. Creppy Selective toxicity of ochratoxin A in primary cultures from different brain regions Arch Toxicol 73 1999 108 114
5. A.M. Bendele, W.W. Carlton, P. Krogh, and E.B. Lillehoj Ochratoxin A carcinogenesis in the (C57BL/6J X C3 H)F1 mouse J Natl Cancer Inst 75 4 1985 733 742
6. E.E. Creppy, R. Roschenthaler, and G. Dirheimer Inhibition of protein synthesis in mice by ochratoxin A and its prevention by phenylalanine Food Chem Toxicol 22 11 1984 883 886
7. J. Dai, G. Park, M.W. Wright, M. Adams, S.A. Akman, and R.A. Manderville Detection and characterization of a glutathione conjugate of ochratoxin A Chem Res Toxicol 15 12 2002 1581 1588
8. V. Faucet, A. Pfohl-Leszkowicz, J. Dai, M. Castegnaro, and R.A. Manderville Evidence for covalent DNA adduction by ochratoxin A following chronic exposure to rat and subacute exposure to pig Chem Res Toxicol 17 9 2004 1289 1296
9. B. Fazekas, A.K. Tar, and M. Zomborszky-Kovács Ochratoxin a contamination of cereal grains and coffee in Hungary in the year 2001 Act Vet Hung 50 2002 177 188
10. H.S. Hussein, and J.M. Brasel Toxicity, metabolism, and impact of mycotoxins on humans and animals Toxicology 167 2 2001 101 134
11. H.G. Kamp, G. Eisenbrand, J. Schlatter, K. Wurth, and C. Janzowski Ochratoxin A: induction of (oxidative) DNA damage, cytotoxicity and apoptosis in mammalian cell lines and primary cells Toxicology 206 3 2005 413 425
12. A.D. Rahimtula, J.C. Bereziat, V. Bussacchini-Griot, and H. Bartsch Lipid peroxidation as a possible cause of ochratoxin A toxicity Biochem Pharmacol 37 23 1988 4469 4477
13. K. Reijula, and T. Tuomi Mycotoxins of aspergilli: exposure and health effects Front Biosci 1;8 2003 232 235
14. C. Renzulli, F. Galvano, L. Pierdomenico, E. Speroni, and M.C. Guerra Effects of rosmarinic acid against aflatoxin B1 and ochratoxin-A-induced cell damage in a human hepatoma cell line (Hep G2) J Appl Toxicol 24 2004 289 296
15. G.J. Schaaf, S.M. Nijmeijer, R.F.M. Maas, P. Roestenberg, E.M. de Groene, and J. Fink-Gremmels The role of oxidative stress in the ochratoxin A-mediated toxicity in proximal tubular cells Biochim Biophys Acta 1588 2002 149 158
16. G.G. Schwartz Hypothesis: does ochratoxin A cause testicular cancer? Cancer Causes Contr 13 1 2002 91 100
17. H. Singh, B. Singh, K.S. Roy, and B. Singh Histochemical/histoenzymic studies in broiler chicks fed aflatoxin, ochratoxin and inoculated with inclusion body hepatitis virus singly and in concurrence Mycopathologia 125 2 1994 119 128
18. M.Y. Siraj, T.D. Phillips, and A.W. Hayes Effects of the mycotoxins citrinin and ochratoxin A on hepatic mixed-function oxidase and adenosinetriphosphatase in neonatal rats Toxicol Environ Health 8 1-2 1981 131 140
19. S.D. Stoev The role of ochratoxin A as a possible cause of Balkan endemic nephropathy and its risk evaluation Vet Hum Toxicol 40 6 1998 352 360
20. I. Studer-Rohr, D.R. Dietrich, J. Schlatter, and C. Schlatter The ooccurrence of ochratoxin A in coffee Food Chem Toxicol 33 1995 341 355
21. G. Valacchi, G. Rimbach, C. Saliou, S.U. Weber, and L. Packer Effect of benzoyl peroxide on antioxidant status, NF-kappa B activity and interleukin-1 alpha gene expression in human keratinocytes Toxicology 165 2-3 2001 225 234
22. H.P. Van Egmond, and G.J.A. Speijers Survey of data on the incidence and levels of ochratoxin A in food and animal feed worldwide Nat Toxins 3 1994 125 144
23. Y.H. Wei, C.Y. Lu, T.N. Lin, and R.D. Wei Effect on ochratoxin A on rat liver mitochondrial respiration and oxidative phosphorylation Toxicology 36 2-3 1985 119 130