A novel achiral seco-amino-cyclopropylindoline (CI) analog of CC-1065 and the duocarmycins: design, synthesis and biological studies.

Medicinal chemistry

Volumn 1, Issue 1, 2005, Pages 13-19

  Toth, James L ^a   Trzupek, John D ^a   Flores, Lloyd V ^a   Kiakos, Konstantinos ^a   Hartley, John A ^a   Pennington, William T ^a   Lee, Moses ^a  

^a FURMAN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 AMINO 3 (CHLOROMETHYL) 1 ((5,6,7 TRIMETHOXYINDOL 2 YL)CARBONYL)INDOLINE; 6-AMINO-3-(CHLOROMETHYL)-1-((5,6,7-TRIMETHOXYINDOL-2-YL)CARBONYL)INDOLINE; ANTINEOPLASTIC ANTIBIOTIC; DUOCARMYCIN SA; INDOLE DERIVATIVE; PYRROLE DERIVATIVE; RACHELMYCIN; UNCLASSIFIED DRUG;

ARTICLE; CELL STRAIN K 562; CHEMICAL STRUCTURE; CHEMISTRY; DRUG DESIGN; DRUG SCREENING; HUMAN; IC 50; STEREOISOMERISM; SYNTHESIS; TUMOR CELL LINE; X RAY CRYSTALLOGRAPHY;

ANTIBIOTICS, ANTINEOPLASTIC; CELL LINE, TUMOR; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INDOLES; INHIBITORY CONCENTRATION 50; K562 CELLS; MOLECULAR STRUCTURE; PYRROLES; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.; STEREOISOMERISM;

EID: 20144383449     PISSN: 15734064     EISSN: None     Source Type: Journal    
DOI: 10.2174/1573406053402523     Document Type: Article

References (0)