Supradose intra-arterial cisplatin and concurrent radiation therapy for the treatment of stage IV head and neck squamous cell carcinoma is feasible and efficacious in a multi-institutional setting: Results of Radiation Therapy Oncology Group Trial 9615

Journal of Clinical Oncology

Volumn 23, Issue 7, 2005, Pages 1447-1454

  Robbins, K Thomas ^a   Kumar, Parvesh ^a   Harris, Jonathan ^a   McCulloch, Timothy ^a   Cmelak, Anthony ^a   Sofferman, Robert ^a   Levine, Paul ^a   Weisman, Robert ^a   Wilson, William ^a   Weymuller, Ernest ^a   Fu, Karen ^a  

^a GEORGE WASHINGTON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CISPLATIN; DEXAMETHASONE; SODIUM THIOSULFATE;

ADULT; AGED; ARTICLE; BLOOD TOXICITY; CANCER RADIOTHERAPY; CANCER RELAPSE; CANCER STAGING; CANCER SURVIVAL; CEREBROVASCULAR ACCIDENT; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE FREE SURVIVAL; DRUG EFFICACY; DRUG TOLERABILITY; FEASIBILITY STUDY; FEMALE; FOLLOW UP; HEAD AND NECK CANCER; HUMAN; HYPOPHARYNX CARCINOMA; INFECTION; LARYNX CARCINOMA; LEUKOPENIA; MAJOR CLINICAL STUDY; MALE; MOUTH CARCINOMA; MUCOSA INFLAMMATION; MULTICENTER STUDY; MYOPATHY; NEUROTOXICITY; NEUTROPENIA; OROPHARYNX CARCINOMA; PARALYSIS; PERIPHERAL NEUROPATHY; PHASE 2 CLINICAL TRIAL; PNEUMONIA; PRIORITY JOURNAL; RADIATION DOSE; RANDOMIZED CONTROLLED TRIAL; SEIZURE; SEPSIS; SIDE EFFECT; SQUAMOUS CELL CARCINOMA; TREATMENT RESPONSE; WEAKNESS; HEAD AND NECK TUMOR; INTRAARTERIAL DRUG ADMINISTRATION; MIDDLE AGED; MORTALITY; MULTIMODALITY CANCER THERAPY; SURVIVAL RATE; TREATMENT OUTCOME;

ADULT; AGED; CARCINOMA, SQUAMOUS CELL; CISPLATIN; COMBINED MODALITY THERAPY; FEASIBILITY STUDIES; FEMALE; FOLLOW-UP STUDIES; HEAD AND NECK NEOPLASMS; HUMANS; INJECTIONS, INTRA-ARTERIAL; MALE; MIDDLE AGED; SURVIVAL RATE; TREATMENT OUTCOME;

EID: 20144374145     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/JCO.2005.03.168     Document Type: Article

References (20)

1. Wolpert SM, Kwan ES, Heros D, et al: Selective delivery of chemotherapeutic agents with a new catheter system. Radiology 166:547-549, 1988
2. Robbins KT, Storniolo AM, Kerber C, et al: Rapid superselective high dose cisplatin infusion for advanced head and neck malignancies. Head Neck 14:364-371, 1992
3. Robbins KT, Storniolo AMS, Kerber C, et al: Phase I study of highly selective supradose cisplatin infusions for advanced head and neck cancer. J Clin Oncol 12:2113-2120, 1994
4. Robbins KT, Vicario D, Seagren S, et al: A targeted supradose cisplatin chemoradiation protocol for advanced head and neck cancer. Am J Surg 168:419-421, 1994
5. Robbins KT, Kumar P, Regine WF, et al: Efficacy of targeted supradose cisplatin and concurrent radiation therapy for advanced head and neck cancer: The Memphis Experience. Int J Radiat Oncol Biol Phys 38:263-271, 1997
6. Robbins KT, Kumar P, Wong FSH, et al: Targeted chemoradiation for advanced head and neck cancer: Analysis of 213 patients. Head Neck 22:687-693, 2000
7. Kumar P, Wan J, Vieira F, et al: Five year outcome analyses following treatment of stage III/IV head and neck (H/N) squamous cell carcinoma (SCCa) using supradose intra-arterial targeted cisplatin (SIT-P) and concurrent radiation therapy (RT). Proc Am Soc Clin Oncol 18:396a, 1999 (abstr 1530)
8. Kumar P, Wan J, Proctor E, et al: The impact of radiation related factors upon long term outcome in the management of advanced head and neck (H/N) squamous cell carcinoma (SCCa) treated with supradose intra-arterial targeted (SIT) cisplatin (P) and radiation therapy (RT). Int J Radiat Oncol Biol Phys 42:321, 1998 (suppl 1, abstr 2188)
9. Cooper JS, Berkey B, Marcial V, et al: Validation of the RTOG recursive partitioning classification for head and neck tumors. Head and Neck 23:669-677, 2001
10. Marcial VA, Pajak TF, Mohiuddin M, et al: Concomitant cisplatin chemotherapy and radiotherapy in advanced mucosal squamous cell carcinoma of the head and neck. Cancer 66:1861-1868, 1990
11. Adelstein DJ, Sharan VM, Earle AS, et al: Simultaneous versus sequential combined technique therapy for head and neck cancer. Cancer 65:1685-1691, 1990
12. Merlano M, Corvo R, Margarino G: Combined chemotherapy and radiation therapy in advanced inoperable squamous cell carcinoma of the head and neck: The final report of a randomized trial. Cancer 67:915-921, 1991
13. Merlano M, Vitale V, Rosso R, et al: Treatment of advanced squamous-cell carcinoma of the head and neck with alternating chemotherapy and radiotherapy. N Engl J Med 327:1115-1121, 1992
14. Jeremic B, Shibamoto Y, Stanisavljevic B, et al: Radiation therapy alone or with concurrent low-dose daily either cisplatin or carboplatin in locally advanced unresectable squamous cell carcinoma of the head and neck: A prospective randomized trial. Radiother Oncol 43:29-37, 1997
15. Wendt TG, Grabenbauer GG, Rödel CM, et al: Simultaneous radiochemotherapy versus radiotherapy alone in advanced head and neck cancer: A randomized multicenter study. J Clin Oncol 16:1318-1324, 1998
16. Brizel DM, Albers ME, Fisher SR, et al: Hyperfractionated irradiation with or without concurrent chemotherapy for locally advanced head and neck cancer. N Engl J Med 338:1798-1804, 1998
17. Browman GP, Cripps C, Hodson DI, et al: Placebo-controlled randomized trial of infusional fluorouracil during standard radiotherapy in locally advanced head and neck cancer. J Clin Oncol 12:2648-2653, 1994
18. Haffty BG, Son YH, Papac R: Chemotherapy as an adjunct to radiation in the treatment of squamous cell carcinoma of the head and neck: Results of the Yale randomized trials. J Clin Oncol 15:268-276, 1997
19. Adelstein DJ, Li Y, Adams GL, et al: An intergroup phase III comparison of standard radiation therapy and two schedules of concurrent chemoradiotherapy in patients with unresectable squamous cell head and neck cancer. J Clin Oncol 21:92-98, 2003
20. Calais G, Alfonsi M, Bardet E, et al: Randomized trial of radiation therapy versus concomitant chemotherapy and radiation therapy for advanced-stage oropharynx carcinoma. J Natl Cancer Inst 91:2081-2086, 1999