Tumor necrosis factor-α blockade in ankylosing spondylitis: A potent but expensive anti-inflammatory treatment or true disease modification?

Arthritis Research and Therapy

Volumn 7, Issue 3, 2005, Pages 121-123

  Van den Bosch, Filip ^a   De Keyser, Filip ^a   Mielants, Herman ^a   Veys, Eric M ^a  

^a GHENT UNIVERSITY HOSPITAL   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

INFLIXIMAB; MATRIX METALLOPROTEINASE; TUMOR NECROSIS FACTOR ALPHA;

ANKYLOSING SPONDYLITIS; ARTICLE; CORRELATION ANALYSIS; COST EFFECTIVENESS ANALYSIS; DISEASE SEVERITY; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; DRUG RESPONSE; DRUG SAFETY; HUMAN; IMMUNE SYSTEM; IMMUNOMODULATION; RISK BENEFIT ANALYSIS;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIRHEUMATIC AGENTS; HUMANS; SPONDYLITIS, ANKYLOSING; TUMOR NECROSIS FACTOR-ALPHA;

EID: 20144372687     PISSN: 14786354     EISSN: None     Source Type: Journal    
DOI: 10.1186/ar1742     Document Type: Article

References (12)

1. Baraliakos X, Listing J, Brandt J, Rudwaleit M, Sieper J, Braun J: Clinical response to discontinuation of anti-TNF therapy in patients with ankylosing spondylitis after 3 years of continuous treatment with infliximab. Arthritis Res Ther 2005, 7:R439-R444.
2. Braun J, Brandt J, Listing J, Zink A, Alten R, Golder W, Gromnica-Ihle E, Kellner H, Krause A, Schneider M, et al.: Treatment of active ankylosing spondylitis with infliximab: a randomised controlled multicentre trial. Lancet 2002, 359:1187-1193.
3. Anderson JJ, Baron G, van der Heijde D, Felson DT, Dougados M: Ankylosing spondylitis assessment group preliminary definition of short-term improvement in ankylosing spondylitis. Arthritis Rheum 2001, 44:1876-1886.
4. Wanders A, van der Heijde D, Landewé R, Behier JM, Calin A, Olivieri I, Zeidler H, Dougados M: Inhibition of radiographic progression in ankylosing spondylitis by continuous use of NSAIDs [abstract]. Arthritis Rheum 2003, 48(Suppl):S233.
5. Jenkinson T, Mallorie P, Whitelock H, Kennedy L, Garrett S, Calin A: Defining spinal mobility in ankylosing spondylitis (AS). The Bath AS metrology index. J Rheumatol 1994, 21:1694-1698.
6. Van den Bosch F, Kruithof E, Baeten D, De Keyser F, Mielants H, Veys EM: Effects of a loading dose regimen of three infusions of chimeric monoclonal antibody to tumour necrosis factor alpha (infliximab) in spondyloartropathy: an open pilot study. Ann Rheum Dis 2000, 59:428-433.
7. Kruithof E, Van den Bosch F, Baeten D, Herssens A, De Keyser F, Mielants H, Veys EM: Repeated infusions of infliximab, a chimeric monoclonal antibody, in patients with active spondyloarthropathy: one year follow-up. Ann Rheum Dis 2002, 61:207-212.
8. Van den Bosch F, Kruithof E, Baeten D, Herssens A, De Keyser F, Mielants H, Veys EM: Randomized, double-blind comparison of chimeric monoclonal antibody to tumour necrosis factor α (infliximab) versus placebo in active spondyloarthropathy. Arthritis Rheum 2002, 46:755-765.
9. Calin A, Garrett S, Whitelock H, Kennedy LG, O'Hea J, Mallorie P, Jenkinson T: A new approach to defining functional ability in ankylosing spondylitis: the development of the Bath Ankylosing Spondylitis Functional Index. J Rheumatol 1994, 21:2281-2285.
10. Baeten D, Kruithof E, Van den Bosch F, Demetter P, Van Damme N, Cuvelier C, De Vos M, Mielants H, Veys EM, De Keyser F: Immunomodulatory effects of anti-tumor necrosis factor alpha therapy on synovium in spondyloarthropathy: histological findings in eight patients from an open-label pilot study. Arthritis Rheum 2001, 44:186-195.
11. Kruithof E, Baeten D, Van den Bosch F, Mielants H, Veys EM, De Keyser F: Histological evidence that infliximab treatment leads to downregulation of inflammation and tissue remodelling of the synovial membrane in spondyloarthropathy. Ann Rheum Dis 2005, 64:529-536.
12. Vandooren B, Kruithof E, Yu DT, Rihl M, Gu J, De Rycke L, Van den Bosch F, Veys EM, De Keyser F, Baeten D: Involvement of matrix metalloproteinases and their inhibitors in peripheral synovitis and down regulation by tumor necrosis factor-α blockade in spondyloarthropathy. Arthritis Rheum 2004, 50:2942-2953.