Diazepam affects the nuclear thyroid hormone receptor density and their expression levels in adult rat brain

Neuroscience Research

Volumn 52, Issue 3, 2005, Pages 269-275

  Constantinou, Caterina ^a   Bolaris, Stamatis ^a,b   Valcana, Theony ^a   Margarity, Marigoula ^a  

^a UNIVERSITY OF PATRAS   (Greece)

^b HELENA VENIZELOU HOSPITAL   (Greece)

Author keywords

Adult brain; Diazepam; Nuclei; Synaptosomal T3; Thyroid hormone receptors; Triiodothyronine

Indexed keywords

DIAZEPAM; LIOTHYRONINE; STEDON; THYROID HORMONE RECEPTOR ALPHA; THYROID HORMONE RECEPTOR ALPHA1; THYROID HORMONE RECEPTOR ALPHA2; THYROID HORMONE RECEPTOR BETA; THYROID HORMONE RECEPTOR BETA1; TRANQUILIZER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; DISSOCIATION CONSTANT; DRUG EFFECT; FEMALE; HEMISPHERE; HORMONE BINDING; IN VITRO STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN VARIANT; RAT; SYNAPTOSOME; THYROID HORMONE BLOOD LEVEL;

ANALYSIS OF VARIANCE; ANIMALS; ANTI-ANXIETY AGENTS; BLOTTING, NORTHERN; BRAIN; DIAZEPAM; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION; IODINE ISOTOPES; LIVER; PROTEIN BINDING; PROTEIN ISOFORMS; RATS; RECEPTORS, THYROID HORMONE; SYNAPTOSOMES; THYROID HORMONES; TRIIODOTHYRONINE;

EID: 20144371102     PISSN: 01680102     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neures.2005.03.011     Document Type: Article

References (54)

1. R. Arem, and K. Cusi Thyroid function testing in psychiatric illness - usefulness and limitations Trends Endocrinol. Metab. 8 1997 282 287
2. M.S. Bauer, and P.C. Whybrow Thyroid hormones and the central nervous system in affective illness: interactions that may have clinical significance Integr. Psychiat. 6 1988 75 100
3. 3 binding to adult rat cerebral nuclei. J. Pharm. Pharmacol.
4. S. Bolaris, C. Constantinou, T. Valcana, and M. Margarity Pentylenetetrazole-induced convulsions affect cellular and molecular parameters of the mechanism of action of triiodothyronine in adult rat brain Neuropharmacology 48 2005 894 902
5. 3) binding to nuclei from rat cerebral hemispheres Biol. Psychiat. 37 1995 106 111
6. M.M. Bradford A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding Anal. Biochem. 72 1976 248 254
7. K.A. Burton Study of the conditions and mechanism of the diphenylamine reaction for the calorimetric estimation of DNA J. Biochem. 62 1956 315 322
8. J.D. Chen, and R.M. Evans A transcriptional corepressor that interact with nuclear receptors Nature 377 1995 454 457
9. C.G. Clower Organic affective syndromes associated with thyroid dysfunction Psychiat. Med. 2 1984 177 181
10. C. Constantinou, S. Bolaris, T. Valcana, and M. Margarity Acute LiCl treatment affects the cytoplasmic T4 availability and the expression pattern of thyroid hormone receptors in adult rat cerebral hemispheres Neurosci. Res. 51 2005 235 241
11. E. Costa, and A. Guidotti Molecular mechanisms in the receptor action of benzodiazepines Annu. Rev. Pharmacol. Toxicol. 19 1979 531 545
12. F.R. Crantz, and P.R. Larsen Rapid thyroxine to 3,5,3′- triiodothyronine conversion and nuclear 3,5,3′-triiodothyronine binding in rat cerebral cortex and cerebellum J. Clin. Invest. 65 1980 935 938
13. F.R. Crantz, J.E. Silva, and P.R. Larsen An analysis of the sources and quantity of 3,5,3′-triiodothyronine specifically bound to nuclear receptors in rat cerebral cortex and cerebellum Endocrinology 110 1982 367 375
14. Y. Dalezios, and N. Matsokis Nuclear benzodiazepine binding: possible interaction with thyroid hormone receptors Neurochem. Res. 18 1993 305 311
15. 125I]-thyroxine Am. J. Physiol. 235 1978 638 647
16. M.B. Dratman, F.L. Crutchfield, J. Axelrod, R.W. Colburn, and T. Nguyen Localization of triiodothyronine in nerve ending fractions of rat brain Proc. Natl. Acad. Sci. U.S.A. 73 1976 941 944
17. N.L. Eberhardt, T. Valcana, and P.S. Timiras Triiodothyronine nuclear receptors: an in vitro comparison of the binding of triiodothyronine to nuclei of adult rat liver, cerebral hemisphere, and anterior pituitary Endocrinology 102 1978 556 561
18. C.-G. Hahn, A.C. Pawlyk, P.C. Whybrow, and S.M. Tejani-Butt Differential expression of thyroid hormone receptor isoform by thyroid hormone and lithium in rat GH3 and B103 cells Biol. Psychiat. 45 1999 1004 1012
19. C.-G. Hahn, A.C. Pawlyk, P.C. Whybrow, L. Gyulai, and S.M. Tejani-Butt Lithium administration affects gene expression of thyroid hormone receptors in rat brain Life Sci. 64 1999 1793 1802
20. R.A. Hodin, M.A. Lazar, and W.W. Chin Differential and tissue-specific regulation of the multiple rat c-erbA messenger RNA species by thyroid hormone J. Clin. Invest. 85 1990 101 105
21. R.A. Hodin, M.A. Lazar, B.I. Wintman, D.S. Darling, R.J. Koenig, P.R. Larsen, D.D. Moore, and W.W. Chin Identification of a novel thyroid hormone receptor that is pituitary specific Science 244 1989 207 211
22. A.J. Horlein, A.M. Naar, T. Heinzel, J. Torchia, B. Gloss, R. Kurokawa, A. Ryan, Y. Kamel, M. Soderstrom, C.K. Glass, and M.G. Rosenfeld Ligand-independent repression by thyroid hormone receptor mediated by a nuclear co-repressor Nature 377 1995 397 404
23. M. Ito, and R.G. Roeder The TRAP/SMCC/Mediator complex and thyroid hormone receptor function Trends Endocrinol. Metab. 12 2001 127 134
24. D. Katz, T.J. Berrodin, and M.A. Lazar The unique c-termini of the thyroid hormone receptor variant c-ErbA alpha 2 and thyroid hormone receptor alpha 1 mediate different DNA-binding and heterodimerization properties Mol. Endocrinol. 6 1992 805 814
25. D. Katz, and M.A. Lazar Dominant negative activity of an endogenous thyroid hormone receptor variant (alpha 2) is due to competition for binding sites on target genes J. Biol. Chem. 268 1993 20904 20910
26. R.W. Katz, and R.J. Koenig Specificity and mechanism of thyroid hormone induction from an octamer response element J. Biol. Chem. 269 1994 18915 18920
27. R.J. Koenig, M.A. Lazar, R.A. Hodin, G.A. Brent, P.R. Larsen, W.W. Chin, and D.D. Moore Inhibition of thyroid hormone action by a non-hormone binding c-erbA protein generated by alternative RNA splicing Nature 337 1989 659 661
28. R.J. Koenig, R.L. Warne, G.A. Brent, J.W. Harney, P.R. Larsen, and D.D. Moore Isolation of a cDNA clone encoding a biologically active thyroid hormone receptor Proc. Natl. Acad. Sci. U.S.A. 85 1988 5031 5035
29. L. Kragie Neuropsychiatric implications of thyroid hormones on benzodiazepine interactions Endocr. Res. 19 1993 1 32
30. M.A. Lazar Thyroid hormone receptors: multiple forms, multiple possibilities Endocr. Rev. 14 1993 240 279
31. M.A. Lazar, R.A. Hodin, D.S. Darling, and W.W. Chin Identification of a rat c-erbAα-related protein which binds deoxyribonucleic acid but does not bind thyroid hormone Mol. Endocrinol. 2 1988 893 901
32. Q. Li, L. Sachs, Y.-B. Shi, and A.P. Wolfe Modification of chromatin structure by thyroid hormone receptor Trends Endocrinol. Metab. 10 1999 157 164
33. S. Malkani, and J.F. Rosen Differential expression of ERG-1 mRNA in the amygdala following diazepam in contextual fear conditioning Brain Res. 860 2000 53 63
34. J.H. Medina, and E. de Robertis Benzodiazepine receptor and thyroid hormones: in vivo and in vitro modulation J. Neurochem. 44 1985 1340 1344
35. T. Mitsuhashi, and V.M. Nikodem Regulation of expression of the alternative mRNAs of the rat α-thyroid hormone receptor gene J. Biol. Chem. 264 1989 8900 8904
36. T. Mitsuhashi, G.E. Tennyson, and V.M. Nikodem Alternative splicing generates messages encoding rat c-erbA proteins that do not bind thyroid hormone Proc. Natl. Acad. Sci. U.S.A. 85 1988 5804 5808
37. A. Nagy, and A. Lajtha Thyroid hormones and derivatives inhibit flunitrazepam binding J. Neurochem. 40 1983 414 417
38. S.-I. Nakao, T. Adachi, M. Murakawa, T. Shinomura, J. Kurata, T. Schichino, M. Shibata, I. Tooyama, H. Kimura, and Mori Halothane and diazepam inhibit ketamine-induced c-fos expression in the rat cingulate cortex Anesthesiology 85 1996 874 882
39. R.W. Olsen GABA-benzodiazepine-barbiturate receptor interactions J. Neurochem. 37 1981 1 13
40. 3 receptor-associating), a family of cofactors that associate with, and modulate the activity of nuclear hormone receptors Mol. Endocrinol. 10 1999 813 825
41. P.K. Sarkar, and A.K. Ray A simple biochemical approach to differentiate synaptosomes and non-synaptic mitochondria from rat brain Meth. Find Exp. Clin. Pharmacol. 14 1992 493 497
42. 3 content in cerebral cortex of adult rat in different thyroidal states Neuropsychopharmacology 11 1994 151 155
43. G. Scatchard The attraction of proteins for small molecules and ions Annu. N.Y. Acad. Sci. 51 1949 660 672
44. G.C. Schussler Diazepam competes for thyroxine binding sites J. Pharmacol. Exp. Ther. 178 1971 204 209
45. W.M. Seol, M.S. Choi, and D.D. Moore Isolation of proteins that interact specifically with the retinoid × receptor: two novel orphan receptors Mol. Endocrinol. 9 1995 72 85
46. K.A. Strait, H.L. Schwartz, A. Perez-Castillo, and J.H. Oppenheimer Relationship of c-erbA mRNA content to tissue triiodothyronine nuclear binding capacity and function in developing and adult rats J. Biol. Chem. 265 1990 10514 10522
47. J. Tagami, P. Kopp, W. Johnson, K. Arserven, and J.L. Jameson The thyroid hormone receptor variant α2 is a weak antagonist because it is deficient in interactions with nuclear co-repressors Endocrinology 139 1998 2535 2544
48. J.F. Tallman, S.M. Paul, P. Skolnick, and D.W. Gallager Receptors for the age of anxiety: pharmacology of the benzodiazepines Science 207 1980 274 281
49. C.C. Thompson, C. Weinberger, R. Lebo, and R.M. Evans Identification of a novel thyroid hormone receptor expressed in the mammalian central nervous system Science 237 1987 1610 1614
50. A.J. White, and B. Barraclough Thyroid disease and mental illness: a study of thyroid disease in psychiatric admissions J. Psychosom. Res. 32 1988 99 106
51. Y. Wu, and R.J. Koenig Gene regulation by thyroid hormone Trends Endocrinol. Metab. 11 2000 207 211
52. Y.Z. Yang, M. Burgos-Trinidad, Y. Wu, and R.J. Koenig Thyroid hormone receptor variant alpha 2. Role of the ninth heptad in DNA binding, heterodimerization with retinoic × receptors, and dominant negative activity J. Biol. Chem. 271 1996 28235 28242
53. P.M. Yen Physiological and molecular basis of thyroid hormone action Physiol. Rev. 81 2001 1097 1142
54. 3-recptor (TR) monomer, homodimer and heterodimer binding to thyroid hormone response elements (TREs) J. Endocr. 1 1993 461 466