Mechanisms of inactivation of HSV-2 during storage in frozen and lyophilized forms

Biotechnology Progress

Volumn 21, Issue 3, 2005, Pages 911-917

  Hansen, Raino K ^a,d   Zhai, Suling ^a   Skepper, Jeremy N ^a   Johnston, Mike D ^b   Alpar, H Oya ^c   Slater, Nigel K H ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b Cantab Pharmaceuticals Ltd   (United Kingdom)

^c UNIVERSITY OF LONDON   (United Kingdom)

^d UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; DNA; FREEZING; IMMUNOLOGY; SCANNING ELECTRON MICROSCOPY; THAWING; TRANSMISSION ELECTRON MICROSCOPY;

ARTIFACTS; HERPES SIMPLEX VIRUS 2 (HSV-2); LYPOPHILIZATION; STRUCTURAL INTEGRITY;

VIRUSES;

HERPES; HUMAN HERPESVIRUS 2; MIRIDAE;

EID: 20144367714     PISSN: 87567938     EISSN: None     Source Type: Journal    
DOI: 10.1021/bp049601a     Document Type: Article

References (30)

1. Armstrong, T. K.; Anchordoquy, T. J. Immobilization of nonviral vectors during the freezing step of lyophilization. J. Pharm. Sci. 2004, 93 (11), 2698-2709.
2. Boursnell, M. E. G.; Entwisle, C.; Ali, S. A.; Sivasubramaniam, S. D.; Reeder, S.; McLean, C. S.; Blakeley, D. M.; Miller, J.; Hill, S.; Shields, J. G.; Inglis, S. C.; Rees, R. C. Disabled infectious single cycle (DISC) herpes simplex virus as a vector for immunotherapy of cancer. In Adv. Exp. Med. Biol. 1998, 451, 379-384.
3. Boursnell, M. E. G.; Entwisle, C.; Blakeley, D.; Roberts, C.; Duncan, I. A.; Chisholm, S. E.; Martin, G. M.; Jennings, R.; Challanain, D. N.; Sobek, I.; et al. A genetically inactivated herpes simplex virus type 2 (HSV-2) vaccine provides effective protection against primary and recurrent HSV-2 disease. J. Infect. Dis. 1997, 175 (1), 16-25.
4. Burke, C. J.; Hsu, T. A.; Volkin, D. B. Formulation, stability, and delivery of live attenuated vaccines for human use. Crit. Rev. Ther. Drug Carrier Systems 1999, 16 (1), 1-83.
5. Dennehy, P. H. Active immunization in the United States, Developments over the past decade. Clin. Microbiol. Rev. 2001, 14 (4), 872-908.
6. Echlin, P. Low-Temperature Microscopy and Analysis; Plenum Press: London, 1992; pp 70-72.
7. Farrell, H. E.; McLean, C. S.; Harley, C.; Efstathiou, S.; Inglis, S.; Minson, A. C. Vaccine potential of a herpes-simplex virus type-1 mutant with an essential glycoprotein deleted. J. Virol. 1994, 68 (2), 927-932.
8. Forrester, A.; Farrell, H.; Wilkinson, G.; Kaye, J.; Davispoynter, N.; Minson, T. Construction and properties of a mutant of herpes-simplex virus type-1 with glycoprotein-H coding sequences deleted. J. Virol. 1992, 66 (1), 341-348.
9. Franks, F. Freeze-drying of bioproducts, putting principles into practice. Eur. J. Pharm. Biopharm. 1998, 45 (3), 221-229.
10. Fu, X. P.; Zhang, X. L. Delivery of herpes simplex virus vectors through liposome formulation. Mol. Ther. 2001, 4 (5), 447-453.
11. Grose, C.; Friedrichs, W. E.; Smith, K. O. Cryopreservation of varicella-zoster virions without loss of structural integrity or infectivity. Intervirology 1981, 15 (3), 154-160.
12. Hansen, R. K.; Broadhurst, R. W.; Skelton, P. C.; Arkin, I. T. Hydrogen/deuterium exchange of hydrophobic peptides in model membranes by electrospray ionization mass spectrometry. J. Am. Soc. Mass Spectrom. 2002, 13 (12), 1376-1387.
13. Hidaka, Z.; Tomaru, K. Vacuum freeze-drying of tobacco leaf tissues infected with cucumber mosaic virus. Virology 1960, 12 (1), 8-13.
14. Lampert, F.; Bahr, G. F.; Rabson, A. S. Herpes simplex virus, dry mass. Science 1969, 166 (909), 1163-1165.
15. Leuenberger, H. Spray freeze-drying - the process of choice for low water soluble drugs? J. Nanopart. Res. 2002, 4 (1-2), 111-119.
16. Loudon, P. T.; Varley, C. A. (Cantab Pharmaceutical). Stabilization of herpes virus preparations. United Kingdom Patent 6,258,362, 2001.
17. Meryman, H. T. Sublimation freeze-drying without vacuum. Science 1959, 130, 628-629.
18. Morgan, C.; Ellison, S. A.; Rose, H. M.; Moore, D. H. Structure and development of viruses as observed in the electron microscope. J. Exp. Med. 1954, 100, 195-202.
19. Nicoll, S.; Brass, A.; Cubie, H. A. Detection of herpes viruses in clinical samples using real-time PCR. J. Virol. Methods 2001, 96 (1), 25-31.
20. O'Keeffe, R.; Johnston, M. D.; Slater, N. K. H. The primary production of an infectious recombinant herpes simplex virus vaccine. Biotechnol. Bioeng. 1998, 57 (3), 262-271.
21. Reed, L. J.; Muench, H. A simple method of estimating fity percent endpoints. Am. J. Hyg. 1938, 27 (3), 493-497.
22. Schneweis, K. E. Über die Haltbarkeit von drei Herpes simplex Virus-Stämmen vei tiefen Temperaturen. Z. Hyg. 1961, 147, 319-326.
23. Smith, K. O. Relationship between the envelope and the infectivity of herpes simplex virus. Proc. Soc. Exp. Biol. Med. 1964, 115, 814-816.
24. Sodeik, B.; Ebersold, M. W.; Helenius, A. Microtubule-mediated transport of incoming herpes simplex virus 1 capsids to the nucleus. J. Cell Biol. 1997, 136 (5), 1007-1021.
25. Stannard, L. M.; Fuller, A. O.; Spear, P. G. Herpes simplex virus glycoproteins associated with different morphological entities projecting from the virion envelope. J. Gen. Virol 1987, 68 (Part 3), 715-725.
26. Taniguchi, S.; Yoshino, K. An analysis of the plaque assay of herpes simplex virus in chick embryo monolayers. Arch. Gesamte Virusforsch. 1964, 14 (4), 537-552.
27. Wang, W. Lyophilization and development of solid protein pharmaceuticals. Int. J. Pharm. 2000, 203 (1-2), 1-60.
28. Weir, J. P. Infection of human NT2 cells and differentiated NT-neurons with herpes simplex virus and replication-incompetent herpes simplex virus vectors. J. Neurovirol. 2001, 7 (1), 43-51.
29. Zhai, S.; Hansen, R. K.; Taylor, R.; Skepper, J. N.; Sanches, R.; Slater, N. K. Effect of freezing rates and excipients on the infectivity of a live viral vaccine during lyophilization. Biotechnol. Prog. 2004, 20 (4), 1113-1120.
30. Zhou, Z. H.; Chen, D. H.; Jakana, J.; Rixon, F. J.; Chiu, W. Visualization of tegument-capsid interactions and DNA in intact herpes simplex virus type 1 virions. J. Virol. 1999, 73 (4), 3210-3218.