Crystal structure of Himalayan mistletoe ribosome-inactivating protein reveals the presence of a natural inhibitor and a new functionally active sugar-binding site

Journal of Biological Chemistry

Volumn 280, Issue 21, 2005, Pages 20712-20721

  Mishra, Vandana ^a,b   Bilgrami, Sameeta ^a   Sharma, Radhey Shyam ^b   Kaur, Punit ^a   Yadav, Savita ^a   Krauspenhaar, Ruth ^c   Betzel, Christian ^c   Voelter, Wolfgang ^d   Babu, Cherukuri R ^b   Singh, Tej P ^a  

^a ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

^b UNIVERSITY OF DELHI   (India)

^c Institute of Medical Biochemistry and Molecular Biology   (Germany)

^d UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; CATALYSIS; ENZYME INHIBITION; PLANTS (BOTANY); PROTEINS; TOXIC MATERIALS; TOXICITY;

LIGANDS; NON-PROTEIN ELECTRON DENSITY; PLANT DEFENSE; RIBOSOME-INACTIVATING PROTEINS (RIP);

CRYSTAL STRUCTURE;

AMIDE; ARGININE; CARBOHYDRATE DERIVATIVE; CARBOXYL GROUP; GALACTOSE; LACTOSE; PHENYLALANINE; PTERIDINE DERIVATIVE; RIBOSOME INACTIVATING PROTEIN; TOXIN; TYROSINE;

ARTICLE; BINDING AFFINITY; BINDING SITE; CATALYSIS; CRYSTAL STRUCTURE; LIGAND BINDING; NONHUMAN; PLANT DEFENSE; PLANT LEAF; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN PURIFICATION; TECHNIQUE; VISCUM ALBUM;

ARGININE; BINDING SITES; CARBOHYDRATE METABOLISM; CONSERVED SEQUENCE; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; LACTOSE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PLANT LEAVES; PLANT PREPARATIONS; PLANT PROTEINS; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; PTERIDINES; TOXINS, BIOLOGICAL; VISCUM;

VISCUM ALBUM;

EID: 20144364945     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M500735200     Document Type: Article

References (64)

1. Nielsen, K., and Boston, R. S. (2001) Annu. Rev. Plant Physiol. Plant Mol. Biol. 52, 785-816
2. Park, S. W., Vepachedu, R., Sharma, N., and Vivanco, J. M. (2004) Planta 219, 1093-1096
3. Park, S. W., Stevens, N. M., and Vivanco, J. M. (2002) Planta 216, 227-234
4. Lam, S. K., and Ng, T. B. (2001) Arch. Biochem. Biophys. 393, 271-280
5. Endo, Y., and Tsurugi, K. (1988) J. Biol. Chem. 263, 8735-8739
6. Peumans, W. J., Hao, Q., and van Damme, E. J. M. (2001) FASEB J. 15, 1493-1506
7. Barbieri, L., Valbonesi, P., Bonora, E., Gorini, P., Bolognesi, A., and Stirpe, F. (1997) Nucleic Acids Res. 25, 518-522
8. Reinbothe, S., Reinbothe, C., Lehmann, J., Becker, W., Apel, K., and Partheir, B. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 7012-7016
9. Parikh, B. A., and Tumer, N. E. (2004) Mini Rev. Med. Chem. 4, 523-543
10. Bolognesi, A., and Polito, L. (2004) Mini Rev. Med. Chem. 4, 563-583
11. Elhaggar, S. (1993) Arch AIDS Res. 7, 120-121
12. Motto, M., and Lupotto, E. (2004) Mini Rev. Med. Chem. 4, 493-503
13. Harley, S., and Beevers, H. (1982) Proc. Natl. Acad. Sci. U. S. A. 79, 5935-5938
14. Frigerio, L., and Roberts, L. M. (1998) J. Exp. Bot. 49, 1473-1480
15. Elpidina, E. N., Voskoboynikova, N. E., Belozersky, M. A., and Dunaevsky, Y. E. (1991) Planta 185, 46-52
16. Hartley, M. R., Chaddock, J. A., and Bonness, M. S. (1996) Trends Plant Sci. 1, 260-268
17. Desvoyes, B., Poyet, J. C., Schlick, J. L., Adami, P., and Jouvenot, P. D. (1997) FEBS Lett. 410, 303-308
18. Schlick, J. L., Desvoyes, B., Hakil, M., Adami, P., and Dulieu, P. (1999) Plant Sci. 140, 1-10
19. Heiny, B. N., Albrecht, V., and Beuth, J. (1998) Anticancer Res. 18, 583-586
20. Hajto, T., Hostanska, K., and Gabius, H. J. (1989) Cancer Res. 49, 4803-4808
21. Kovacs, E. (2000) Biomed. Pharmacother. 54, 305-310
22. Gabius, H. J., and Gabius, S. (1991) Lectins and Cancer, Springer-Verlag, Heidelberg, Germany
23. Lee, R. T., Gabius, H. J., and Lee, Y. C. (1992) J. Biol. Chem. 267, 23722-23727
24. Youle, R. J., Murray, G. L., and Neville, D. M. J. (1981) Cell 23, 551-559
25. Mishra, V., Sharma, R. S., Yadav, S., Babu, C. R., and Singh, T. P. (2004) Arch. Biochem. Biophys. 423, 288-301
26. Otwinowski, Z., and Minor, W. (1997) Methods Enzymol. 276, 307-326
27. Navaza, J. (1994) Acta Crystallogr. Sect, A 50, 157-163
28. Mishra, V., Ethayathulla, A. S., Sharma, R. S., Yadav, S., Krauspenhaar, R., Betzel, C., Babu, C. R., and Singh, T. P. (2004b) Acta Crystallogr. Sect. D Biol. Crystallogr. 60, 2295-2304
29. Murshudov, G. N., Vagin, A. A., Lebedev, A., Wilson, K. S., and Dodson, E. J. (1999) Acta Crystallogr. Sect. D Biol. Crystallogr. 55, 247-255
30. Winn, M. D., Isupov, M. N., and Murshudov, G. N. (2001) Acta Crystallogr. Sect. D Biol. Crystallogr. 57, 122-133
31. Jones, T. A., Zou, J. Y., Cowan, S. W., and Kjeldgaard, M. (1991) Acta Crystallogr. Sect. A 47, 110-119
32. Ramachandran, G. N., and Sasisekharan, V. (1968) Adv. Protein Chem. 23, 283-437
33. Laskowski, R. A., MacArthur, M. W., Moss, D. S., and Thornton, J. M. (1993) J. Appl. Crystallogr. 26, 283-291
34. Niwa, H., Tonevitsky, A. G., Agapov, I. I., Saward, S., Pfüller, U., and Palmer, R. A. (2003) Eur. J. Biochem. 270, 2739-2749
35. Krauspenhaar, R., Eschenburg, S., Perbandt, M., Kornilov, V., Konareva, N., Mikailova, I., Stoeva, S., Wacker, R., Maier, T., Singh, T. P., Mikhailov, A., Voelter, W., and Betzel, C. (1999) Biochem. Biophys. Res. Commun. 257, 418-424
36. Rutenber, E., Katzin, B. J., Ernst, S., Collins, E. J., Mlsna, D., Ready, M. P., and Robertus, J. D. (1991) Proteins 10, 241-250
37. Pascal, J. M., Day, P. J., Monzingo, A. F., Ernst, S. R., Robertus, J. D., Iglesias, R., Perez, Y., Ferreras, J. M., Citores, L., and Girbes, T. (2001) Proteins 43, 319-326
38. Tahirov, T. H., Lu, T. H., Liaw, Y. C., Chen, Y. L., and Lin, J. Y. (1995) J. Mol. Biol. 250, 354-367
39. Gu, Y. J., and Xia, Z. X. (2000) Proteins 39, 37-46
40. Mishra, V. (2004) Ribosome Inactivating Protein of Viscum album (L.) from North-western Himalaya: Purification and Characterization. Ph.D. thesis, University of Delhi, Delhi, India
41. Kurinov, I. V., Myers, D. E., Irvin, J. D., and Uckun, F. M. (1999) Protein Sci. 8, 1765-1772
42. Yan, X., Hollis, T., Svinth, M., Day, P., Monzingo, A. F., Milne, G. W. A., and Robertus, J. D. (1997) J. Mol. Biol. 266, 1043-1049
43. Robertus, J. D., Yan, X., Ernst, S., Monzingo, A., Worley, S., Day, P., Hollis, T., and Svinth, M. (1996) Toxicon 34, 1325-1334
44. Oettle, K., and Reibnegger, G. (1999) Biochim. Biophys. Acta 1430, 387-395
45. Bagga, S., Seth, D., and Batra, J. K. (2003) J. Biol. Chem. 278, 4813-4820
46. Ren, J., Wang, Y., Dong, Y., and Stuart, D. (1994) Structure 2, 7-16
47. Ready, M. P., Kim, Y., and Robertus, J. D. (1991) Proteins 10, 270-278
48. Huang, Q., Liu, S., Tang, Y., Jin, S., and Wang, Y. (1995) Biochem. J. 309, 285-298
49. Day, P. J., Ernst, S. R., Frankel, A. E., Monzingo, A. F., Pascal, J. M., Molin-Svinth, M. C., and Robertus, J. D. (1996) Biochemistry 35, 11098-11103
50. Monzingo, A. F., and Robertus, J. D. (1992) J. Mol. Biol. 227, 1136-1145
51. Yan, X., Day, P., Hollis, T., Monzingo, A. F., Shelp, E., Robertus, J. D., Milne, G. W. A., and Wang, S. (1998) Proteins 31, 33-41
52. Rutenber, E., Ready, M., and Robertus, J. D. (1987) Nature 326, 624-626
53. Rutenber, E., and Robertus, J. D. (1991) Proteins 10, 260-269
54. Weis, W. I., and Drickamer, K. (1996) Annu. Rev. Biochem. 65, 441-473
55. Lee, R. T., Gabius, H. J., and Lee, Y. C. (1994) Carbohydr. Res. 254, 269-276
56. Steeves, R. M., Denton, M. E., Barnard, F. C., Henry, A., and Lambert, J. M. (1999) Biochemistry 38, 11677-11685
57. Frankel, A., Tagge, E., Chandler, J., Burbage, C., and Willingham, M. (1996) Protein Eng. 9, 371-379
58. Houston, L., and Dooley, L. (1982) J. Biol. Chem. 257, 4147-4151
59. Ziska, P., Gelbin, M., and Franz, H. (1993) Lectin Biol. Biochem. Clin. Biochem. 8, 10-13
60. Bussing, A. (ed) (2000) Mistletoe: The Genus Viscum, Harwood Academic Publisher, Amsterdam
61. Mishra, V., Sharma, R. S., Paramasivam, M., Bilgrami, S., Yadav, S., Srinivasan, A., Betzel, C., Babu, C. R., and Singh, T. P. (2005) Plant Sci. 168, 615-625
62. Esnouf, R. M. (1997) J. Mol. Graph. Model 15, 132-134
63. Kraulis, P. J. (1991) J. Appl. Crystallogr. 24, 946-950
64. Merritt, E. A., and Murphy, M. E. P. (1994) Acta Crystallogr. Sect. D Biol. Crystallogr. 50, 869-873