Conjugate of bovine hemoglobin and human serum albumin as a candidate for blood substitute: Characteristics and effects on rats

Artificial Cells, Blood Substitutes, and Immobilization Biotechnology

Volumn 33, Issue 2, 2005, Pages 83-99

  Lu, Xiu Ling ^a   Zheng, Chun Yang ^a   Xiao DongShi, ^a   Wang, Yong Quan ^b   Suo, Xiao Yan ^b   Yu, Peng Zhan ^b   Xu, Yu Hong ^b   Ma, Tie Min ^c   Su, Zhi Guo ^a,d  

^a INSTITUTE OF PROCESS ENGINEERING   (China)

^b UNIVERSITY OF SCIENCE AND TECHNOLOGY BEIJING   (China)

^c BEIJING UNIVERSITY OF CHEMICAL TECHNOLOGY   (China)

^d PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

Blood substitutes; Bovine hemoglobin; Conjugate; Glutaraldehyde; Human serum albumin

Indexed keywords

BIOLOGICAL ORGANS; BIOMEDICAL ENGINEERING; BLOOD SUBSTITUTES; MOLECULAR WEIGHT; OLIGOMERS; PROTEINS;

BLOOD PRESSURE; BOVINE HEMOGLOBIN (BHB); HUMAN SERUM ALBUMIN (HSA); KIDNEY; LIVER;

HEMOGLOBIN;

BLOOD SUBSTITUTE; BOVINE HEMOGLOBIN; BOVINE HEMOGLOBIN HUMAN SERUM ALBUMIN CONJUGATE; GLUTARALDEHYDE; HEMOGLOBIN; HUMAN SERUM ALBUMIN; RINGER LACTATE SOLUTION; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLEEDING; BLOOD SUBSTITUTION; CONJUGATE; CONTROLLED STUDY; GEL PERMEATION CHROMATOGRAPHY; GUINEA PIG; HEMORRHAGIC SHOCK; HISTOPATHOLOGY; ISOELECTRIC FOCUSING; MEAN ARTERIAL PRESSURE; MOLECULAR WEIGHT; NEPHROTOXICITY; NONHUMAN; OSMOTIC PRESSURE; PRESSOR RESPONSE; RAT; RESUSCITATION; STROMA; SURVIVAL RATE;

ANIMALS; BLOOD PRESSURE; BLOOD SUBSTITUTES; CATTLE; DIMERIZATION; HEMOGLOBINS; HEMORRHAGE; HUMANS; POLYMERS; RATS; RATS, SPRAGUE-DAWLEY; SERUM ALBUMIN; SHOCK, HEMORRHAGIC; SURVIVAL RATE;

ANIMALIA; BOVINAE; CAVIA PORCELLUS; SUS SCROFA;

EID: 20044396382     PISSN: 10731199     EISSN: None     Source Type: Journal    
DOI: 10.1081/BIO-200055841     Document Type: Article

References (23)

1. Baldwin, A.L., Wilson, L.M., Valeski, J.E. (1998). Ultrastructural effects of intravascularly injected polyethylene glycol-hemoglobin in intestinal mucosa. Am. J. Physiol. 275: H615-H625.
2. Chang, T.M.S. (1964). Semi-permeable microcapsules. Science 146: 524-525.
3. Chang, T.M.S. (1997). Blood Substitues: Principle, Methods, Products and Clinical Trials. Karger Publisher 1-141, Basel, (www.medicine.mcgill.ca/artcell/ 1972bookCovercr.pdf)
4. Chang, T.M.S. (2000). Red blood cell substitues. Best Pract. Res. Clin. Haematol 13: 651-668.
5. Chang, T.M.S., Varma, R. (1992). Effect of a single replacement of one of ringer lactate, hypertonic saline/Dextran, 7g% albumin, stroma-free hemoglobin, o-raffinose polyhemoglobin or whole blood on the long term survival of unanesthetized rates with lethal hemorrhagic shock after 67% acute blood loss. Biomat Art. Cells & Immob. Biotech. 20(2-4): 503-510.
6. Cheng, D.C. (2001). Safety and efficacy of o-raffinose cross-linked human hemoglobin (Hemolink) in cardiac surgery. Can J Anaesth. 48(4 suppl): S41-48.
7. D'Agnillo, F., Alayash, A.I. (2000). Site-specific modifications and toxicity of blood substitutes, the case of diaspirin cross-linked hemoglobin. Advanced Drug Delivery Reviews 40: 199-212.
8. Drabkin, D. (1949). The standardization of hemoglobin measurement. Am. J. Med. Sci. 217: 710-711.
9. Dubrow, A., Flamenbaum, W. (1988). Acute renal failure associated with myoglobinuria and hemoglobinuria, in Acute Renal Failure, B.M. Brenner, J.M. Lazarus, Eds., New York: Churchill Livingstone, 279-293.
10. Evelyn, K.A., Malloy, H.T. (1938). Microdetermination of oxyhemoglobin, methemoglobin, and sulfhemoglobin in a single sample of blood. J. Biol. Chem. 126: 655-662.
11. Flaim, S. (1997). Perflubron-based emulsion: efficacy as temporary oxygen carrier, in Advances in Blood Substitutes, Industrial Opportunities and Medical Challenges, R.M. Winslow, K. Vandegriff, M. Intaglietta, Eds., Boston: Brikhäuser.
12. Hu, T., Su, Z.G. (2003). Solid phase adsorption method for preparation of bovine serum albumin-bovine hemoglobin conjugate. Journal of Biotechnology 100(3): 267-275.
13. Lu, X.L., Zhao, D.X., Su, Z.G. (2004). Purification of hemoglobin by ion exchange chromatography in flow-through mode with PEG as an escort. Artif. Cells, Blood Substit. and Biotechnol. 32(2): 209-227.
14. Manning, L.R., Morgan, S., Beavis, R.C., Chait, B.T., Manning, J.M., Hess, J.R., Cross, M., Currell, D.L., Marini, M.A., Winslow, R.M. (1991). Preparation, properties, and plasma retention of human hemoglobin derivatives: comparison of uncrosslinked carboxymethylated hemoglobin with crosslinked tetrameric hemoglobin. Proc. Natl. Acad. Sci. USA 88(8): 3329-3333.
15. Palaparthy, R., Wang, H., Gulati, A. (2000). Current aspects in pharmacology of modified hemoglobins. Advanced Drug Delivery Reviews 40: 185-198.
16. Przybelski, R.J., Daily, E.K., Kisicki, J.C., Mattia-Goldberg, C., Bounds, M.J., Colburn, W.A. (1996). Phase I study of the safety and pharmacologic effects of diaspirin cross-linked hemoglobin solution. Crit. Care Med. 24: 1993-2000.
17. 2 affinity. Am J. Physiol. 276: (Heart Circ. Physiol. 45): 553-562.
18. Sakai, H., Yuasa, M., Onuma, H., Takeoka, S., Tsuchida, E. (2000). Synthesis and physicochemical characterization of a series of hemoglobin-based oxygen carriers: objective comparison between cellular and acellular types. Bioconjugate Chem., 11: 56-64.
19. Schneeberger, E.E. (1988). Interaction of plasma proteins with negatively charged sites on the pulmonary capillary endothelium of the rat. Cell Tissue Res. 251: 417-423.
20. Winslow, R.M. (2000). Blood substitutes. Advanced Drug Delivery Reviews 40: 131-142.
21. Winslow, R. W. (2003). Current status of blood substitute research: towards a new paradigm. Journal of Internal Medicine 253: 508-517.
22. Winslow, R.M. (1993). The toxicity of hemoglobin, in Hemoglobin-Based Red Blood Cell Substitutes, R.M. Winslow, Ed., Baltimore: John Hopkins University Press, 136-163.
23. 2 delivery by low-P50 hemoglobin: a new basis for hemoglobin-based oxygen carriers. Artificial Blood 11(1): 45.