Amygdala damage impairs emotional memory for gist but not details of complex stimuli

Nature Neuroscience

Volumn 8, Issue 4, 2005, Pages 512-518

  Adolphs, Ralph ^a,b   Tranel, Daniel ^b   Buchanan, Tony W ^b  

^a CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

^b UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYGDALOID NUCLEUS; ARTICLE; BRAIN FUNCTION; BRAIN INJURY; BRAIN SIZE; CLINICAL ARTICLE; CONTROLLED STUDY; EMOTION; HUMAN; MEMORY DISORDER; MODEL; NEUROBIOLOGY; NEUROPATHOLOGY; PRIORITY JOURNAL; TASK PERFORMANCE; ADULT; BRAIN MAPPING; CHRONIC BRAIN DISEASE; CLASSIFICATION; COMPARATIVE STUDY; FEMALE; FOLLOW UP; HEMISPHERIC DOMINANCE; HIPPOCAMPUS; MALE; MEMORY; MIDDLE AGED; NEUROPSYCHOLOGICAL TEST; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY;

ADULT; AMYGDALA; BRAIN DAMAGE, CHRONIC; BRAIN MAPPING; EMOTIONS; FEMALE; FOLLOW-UP STUDIES; FUNCTIONAL LATERALITY; HIPPOCAMPUS; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MEMORY; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS;

EID: 20044390614     PISSN: 10976256     EISSN: None     Source Type: Journal    
DOI: 10.1038/nn1413     Document Type: Article

References (39)

1. Christianson, S.-A. & Loftus, E.F. Remembering emotional events: the fate of detailed information. Cogn. Emotion 5, 81-108 (1991).
2. Reisberg, D. & Heuer, F. in Affect and Accuracy in Recall: Studies of 'Flashbulb' Memories (eds. Winograd, E. & Neisser, U.) 163-190 (Harvard Univ. Press, Cambridge, Massachusetts, 1992).
3. Burke, A., Heuer, F. & Reisberg, D. Remembering emotional events. Mem. Cognit. 20, 277-290 (1992).
4. Wessel, I. & Merckelbach, H. Memory for threat-relevant and threat-irrelevant cues in spider phobics. Cogn. Emotion 12, 93-104 (1998).
5. Loftus, E.F. Eyewitness Testimony (Harvard Univ. Press, Cambridge, Massachusetts, 1979).
6. Maass, A. & Koehnken, G. Eyewitness identification. Law Hum. Behav. 13, 397-408 (1989).
7. Cahill, L. & McGaugh, J.L. Mechanisms of emotional arousal and lasting declarative memory. Trends Neurosci. 21, 294-299 (1998).
8. Canli, T., Zhao, Z., Brewer, J., Gabrieli, J.D.E. & Cahill, L. Event-related activation in the human amygdala associates with later memory for individual emotional experience. J. Neurosci. 20, RC99 (2000).
9. Hamann, S.B., Ely, T.D., Grafton, ST. & Kilts, C.D. Amygdala activity related to enhanced memory for pleasant and aversive stimuli. Nat. Neurosci. 2, 289-293 (1999).
10. Phelps, E.A. et al. Specifying the contributions of the human amygdala to emotional memory: a case study. Neurocase 4, 527-540 (1998).
11. Adolphs, R., Cahill, L., Schul, R. & Babinsky, R. Impaired declarative memory for emotional material following bilateral amygdala damage in humans. Learn. Mem. 4, 291-300 (1997).
12. McGaugh, J.L. The amygdala modulates the consolidation of memories of emotionally arousing experiences. Annu. Rev. Neurosci. 27, 1-28 (2004).
13. Kensinger, E.A. & Corkin, S. Two routes to emotional memory: distinct neural processes for valence and arousal. Proc. Natl. Acad. Sci. USA 101, 3310-3315 (2004).
14. Rauch, S.L. et al. A symptom provocation study of posttraumatic stress disorder using positron emission tomography and script-driven imagery. Arch. Gen. Psychiatry 53, 380-387 (1996).
15. Mori, E. et al. Amygdalar volume and emotional memory in Alzheimer's disease. Am. J. Psychiatry 156, 216-222 (1999).
16. Adolphs, R., Denburg, N. & Tranel, D. The amygdala's role in declarative memory for gist and detail. Behav. Neurosci. 115, 983-992 (2001).
17. Smith, A.P., Dolan, R.J. & Rugg, M.D. Event-related potential correlates of the retrieval of emotional and nonemotional context. J. Cogn. Neurosci. 16, 760-775 (2004).
18. Cahill, L. & McGaugh, J.L. A novel demonstration of enhanced memory associated with emotional arousal. Conscious. Cogn. 4, 410-421 (1995).
19. Adolphs, R. & Tranel, D. in The Amygdala. A Functional Analysis (ed. Aggleton, J.P.) 587-630 (Oxford Univ. Press, New York, 2000).
20. Easterbrook, J.A. The effect of emotion on cue utilization and the organization of behavior. Psychol. Rev. 66, 183-201 (1959).
21. LaBar, K.S. & Phelps, E.A. Arousal-mediated memory consolidation: role of the medial temporal lobe in humans. Psychol. Sci. 9, 490-494 (1998).
22. Parker, A., Wilding, E. & Akerman, C. The von Restorff effect in visual object recognition memory in humans and monkeys: the role of frontal/perirhinal interaction. J. Cogn. Neurosci. 10, 691-703 (1998).
23. Phelps, E.A., LaBar, K.S. & Spencer, D.D. Memory for emotional words following unilateral temporal lobectomy. Brain Cogn. 35, 85-109 (1997).
24. Brierley, B., Medford, N., Shaw, P. & David, A.S. Emotional memory and perception in temporal lobectomy patients with amygdala damage. J. Neurol. Neurosurg. Psychiatry 75, 593-599 (2004).
25. Hamann, S.B., Cahill, L. & Squire, L.R. Emotional perception and memory in amnesia. Neuropsychology 11, 104-113 (1997).
26. Cahill, L. et al. Sex-related difference in amygdala activity during emotionally influenced memory storage. Neurobiol. Learn. Mem. 75, 1-9 (2001).
27. Canli, T., Desmond, J.E., Zhao, Z. & Gabrieli, J.D.E. Sex differences in the neural basis of emotional memories. Proc. Natl. Acad. Sci. USA 99, 10789-10794 (2002).
28. Cahill, L. & van Stegeren, A. Sex-related impairment of memory for emotional events with beta-adrenergic blockade. Neurobiol. Learn. Mem. 79, 81-88 (2003).
29. Dolan, R.J., Lane, R., Chua, P. & Fletcher, P.C. Dissociable temporal lobe activations during emotional episodic memory retrieval. Neuroimage 11, 203-209 (2000).
30. Packard, M.G. & Chen, S.A. The basolateral amygdala is a cofactor in memory enhancement produced by intrahippocampal glutamate injections. Psychobiology 27, 377-385 (1999).
31. Gale, G.D. et al. Role of the basolateral amygdala in the storage of fear memories across the adult lifetime of rats. J. Neurosci. 24, 3810-3815 (2004).
32. Dolcos, F., LaBar, K.S. & Cabeza, R. Interaction between the amygdala and the medial temporal lobe memory system predicts better memory for emotional events. Neuron 42, 855-863 (2004).
33. Bechara, A. et al. Double dissociation of conditioning and declarative knowledge relative to the amygdala and hippocampus in humans. Science 269, 1115-1118 (1995).
34. Richardson, M.P., Strange, B.A. & Dolan, R.J. Encoding of emotional memories depends on amygdala and hippocampus and their interaction. Nat. Neurosci. 7, 278 285 (2004).
35. Ikegaya, Y., Saito, H. & Abe, K. The basomedial and basolateral amygdaloid nuclei contribute to the induction of long-term potentiation in the dentate gyrus in vivo. Eur. J. Neurosci. 8, 1833-1839 (1996).
36. Akirav, I. & Richter-Levin, G. Biphasic modulation of hippocampal plasticity by behavioral stress and basolateral amygdala stimulation in the rat. J. Neurosci. 19, 10530-10535 (1999).
37. Frank, R.J., Damasio, H. & Grabowski, T.J. Brainvox: an interactive, multi-modal visualization and analysis system for neuroanatomical imaging. Neuroimage 5, 13-30 (1997).
38. Lang, P.J., Oehman, A. & Vaitl, D. The International Affective Picture System (Univ. of Florida, Gainesville, Florida, 1988).
39. Allen, J.S., Tranel, D., Bruss, J. & Damasio, H. Correlations between regional brain volumes and memory performance in anoxia. J. Clin. Neuropsychol. (in press).