Clinical effects of intra-arterial infusion chemotherapy with cisplatin, mitomycin C, leucovorin and 5-flourouracil for unresectable advanced hepatocellular carcinoma

Journal of the Chinese Medical Association

Volumn 67, Issue 12, 2004, Pages 602-610

  Lin, Chi Pin ^c   Yu, Hsien Chung ^a   Cheng, Jin Shiung ^a   Lai, Kwok Hung ^a   Lo, Gin Ho ^a   Hsu, Ping I ^a   Lin, Chiun Ku ^a   Chen, Hoi Hung ^a   Lo, Ching Chu ^a   Liang, Huei Lung ^b   Tseng, Hui Hwa ^b  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b KAOHSIUNG VETERANS GENERAL HOSPITAL   (Taiwan)

^c God's Help Hospital   (Taiwan)

Author keywords

5 fluorouracil; Chemotherapy; Cisplatin; Hepatocellular carcinoma; Mitomycin C

Indexed keywords

ALPHA FETOPROTEIN; CISPLATIN; FLUOROURACIL; FOLINIC ACID; HEPARIN; METOCLOPRAMIDE; MITOMYCIN; TUMOR MARKER;

ANOREXIA; ARTERY CATHETERIZATION; ARTERY OCCLUSION; ARTICLE; CACHEXIA; CANCER COMBINATION CHEMOTHERAPY; CANCER CONTROL; CANCER SURVIVAL; CLINICAL TRIAL; CONSERVATIVE TREATMENT; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE COURSE; DISEASE SEVERITY; DOSE RESPONSE; DRUG INDICATION; ESOPHAGUS VARICES BLEEDING; FEMALE; FOLLOW UP; GASTROINTESTINAL HEMORRHAGE; HEPATIC ENCEPHALOPATHY; HUMAN; LEUKOPENIA; LIVER CELL CARCINOMA; LIVER FAILURE; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; NAUSEA; PREDICTION; PROGNOSIS; RISK REDUCTION; SHORT COURSE THERAPY; THROMBOCYTOPENIA; THROMBOSIS; TREATMENT OUTCOME; VOMITING;

AGED; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CARCINOMA, HEPATOCELLULAR; CISPLATIN; DRUG ADMINISTRATION SCHEDULE; FEMALE; FLUOROURACIL; HEPATIC ARTERY; HUMANS; INFUSIONS, INTRA-ARTERIAL; LEUCOVORIN; LIVER NEOPLASMS; MALE; MIDDLE AGED; MITOMYCIN; SURVIVAL RATE;

EID: 20044386482     PISSN: 17264901     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Okuda K, Ohtsuki T, Obata H, Tomimatsu M, Okazaki N, Hasegawa H, et al. Natural history of hepatocellular carcinoma and prognosis in relation to treatment: study of 850 patients. Cancer 1985;56:918-28.
2. van Eden H, Falkson G, Burger W, Ansell SM. 5-fluorouracil and leucovorin in hepatocellular carcinoma. Ann Oncol 1992; 3:404-5.
3. Okuda S, Okazaki N, Nose H, Shimada Y, Yoshimori M, Aoki K. A phase 2 study of cisplatin in patients with hepatocellular carcinoma. Oncology 1993;50:22-6.
4. Wierzbichi R, Ezzat A, Abdel-Warith A, Ayoub A, Kagevi I, Fadda M, Sicck J. Phase II trial of chronic daily VP-16 administration in unresectable hepatocellular carcinoma (HCC). Ann Oncol 1994;5:466-7.
5. Lai KH, Tsai YT, Lee SD, Ng WW, Teng HC, Tam TN, et al. Phase II study of mitoxantrone in unresectable primary hepatocellular carcinoma following hepatitis B infection. Cancer Chemother Pharmacol 1989;23:54-65.
6. Lai KH, Tsai YT, Lee SD, Yeh YS, Wang SS, Ng WW, et al. Clinical trial of doxifluridine in the treatment of primary hepatocellular carcinoma. Cancer Treat Rep 1986;70:1339-40.
7. Klopp CT, Alford C, Bateman J, Berry GN, Winship T. Fractionated intra-arterial cancer: chemotherapy with methyl bisamine hydrochloride. Ann Surg 1950;132:811-32.
8. Kemeny NE. Is hepatic infusion of chemotherapy effective treatment for liver metastases? Adv Oncol 1992;207-27.
9. Seno H, Ito K, Kojima K, Nakajima N, Chiba T. Efficacy of an implanted drug delivery system for advanced hepatocellular carcinoma using 5-fluorouracil, epirubicin and mitomycin C. J Gastroenterol Hepatol 1999;14:811-6.
10. Ando E, Yamashita F, Tanaka M, Tanikawa K. A novel chemotherapy for advanced hepatocellular carcinoma with tumor thrombosis of the man trunk of the portal vein. Cancer 1997;79:1890-6.
11. Sakai Y, Izumi N, Tazawa J, Yoshida T, Sakai H, Yauchi T, et al. Treatment for advanced hepatocellular carcinoma by transarterial chemotherapy using reservoirs or one-shot arterial chemotherapy. J Chemother 1997;9:347-51.
12. Urabe T, Kaneko S, Matsushita E, Unoura M, Kobayashi K. Clinical pilot study of intrahepatic arterial chemotherapy with methotrexate, 5-fluorouracil, cisplatin, and subcutaneous interferon-alpha-2b for patients with locally advanced hepatocellular carcinoma. Oncology 1998;55:39-47.
13. Makela J, Tikkakoski T, Leinonen A, Siniluoto T, Karttunen A, Kairaluoma MI. Superselective intra-arterial chemotherapy with Mitomycin C in hepatic neoplasms. Eur J Surg Oncol 1993;19:348-54.
14. Kurth S, Bulian D, Kreft B, Riemenschneider T. Intraarterial hepatic chemotherapy with fluorouracil, fluorodeoxyuridine, mitomycin C, cisplatin or methotrexate as single-agent anti-cancer drugs for a transplanted experimental liver tumor in rats. J Cancer Res Clin Oncol 1996;122:421-6.
15. Yamashita Y, Takahashi M, Koga Y, Saito R, Nanakawa S, Hatanaka Y, Sato N. Prognostic factors in the treatment of hepatocellular carcinoma with transcatheter arterial embolization and arterial infusion. Cancer 1991;67:385-91.
16. Minoyama A, Yoshikawa M, Ebara M, Saisho H, Sugiura N, Ohto M. Study of repeated arterial infusion chemotherapy with a subcutaneously implant reservoir for advanced hepatocellular carcinoma. J Gastroenterology 1995;30:356-66.
17. Toyoda H, Nakano S, Kumada T, Takeda I, Sugiyama K, Osada T, et al. The efficacy of continuous local arterial infusion of 5-fluorouracil and cisplatin through an implanted reservoir for severe advanced hepatocellular carcinoma. Oncology 1995;52:295-9.
18. Nakamura K, Takashima S, Takada K, Fujimoto K, Kaminou T, Nakatsuka H, et al. Clinical evaluation of intermittent arterial infusion chemotherapy with an implantable reservoir for hepatocellular carcinoma. Cancer Chemother Pharmacol 1992;31(Suppl):93-8.
19. Takayasu K, Moriyama, N, Muramatsu Y, Suzuki M, Yamada T, Kishi K, et al. Hepatic arterial embolization for hepatocellular carcinoma: comparison of CT scans and resected specimens. Radiology 1984;150:661-5.
20. Maeta M, Koga S, Yoshioka H, Murakami A, Wakatsuki T. T. Intra-hepato-arterial infusions of cis-diamminedichloro-platinum (II) and 5-fluorouracil clinically effective for malignant liver tumors. Jpn J Surg 1985;15:318-20.
21. Doci R, Bignami P, Bozzetti F, Bonfanti G, Audisio R, Colombo M, Gennari L. Intrahepatic chemotherapy for unresectable hepatocellular carcinoma. Cancer 1988;61:1983-7.
22. Yasui M, Nonami T, Kurokawa T, Nakao A, Harda A, Hashimoto S, et al. Effects of hepatic arterial infusion chemotherapy on unresectable or recurrent hepatocellular carcinoma. Cancer Chemother Pharmacol 1994;33(Suppl): 139-41.
23. Iwamiya T, Sawada S, Ohta Y. Repeated arterial infusion chemotherapy for inoperable hepatocellular carcinoma using an implantable drug delivery system. Chemother Pharmacol 1994;33(Suppl):134-8.
24. Jang JW, Park YM, Bae SH, Choi JY, Yoon SK, Chang UI, et al. Therapeutic efficacy of multimodal combination therapy using transcatheter arterial infusion of epirubicin and cisplatin, systemic infusion of 5-fluorouracil, and additional percutaneous ethanol injection for unresectable hepatocellular carcinoma. Cancer Chemother Pharmacol 2004;Jul 3(Epub ahead of print).