The effect of cetirizine on IFN-γ and IL-10 production in children with allergic rhinitis

Turkish Journal of Pediatrics

Volumn 47, Issue 2, 2005, Pages 111-115

  Uǧuz, Ayşen ^a   Şanlioǧlu, Salih ^a   Yüzbey, Selma ^a   Coşkun, Mesut ^a   Yeǧin, Olcay ^a  

^a AKDENIZ UNIVERSITY   (Turkey)

Author keywords

Allergic rhinitis; Cetirizine; IFN ; IL 10; IL 4

Indexed keywords

ANTIHISTAMINIC AGENT; CETIRIZINE; GAMMA INTERFERON; HOUSE DUST ALLERGEN; INTERLEUKIN 10; INTERLEUKIN 4;

ALLERGIC DISEASE; ALLERGIC RHINITIS; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BLOOD SAMPLING; CHILD; CHILDHOOD DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HOUSE DUST ALLERGY; HUMAN; HUMAN CELL; IMMUNE RESPONSE; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; TH1 CELL; TH2 CELL;

CETIRIZINE; CHILD; CYTOKINES; FEMALE; HISTAMINE H1 ANTAGONISTS, NON-SEDATING; HUMANS; INTERFERON TYPE II; INTERLEUKIN-10; LEUKOCYTES, MONONUCLEAR; MALE; RHINITIS, ALLERGIC, PERENNIAL; TH1 CELLS; TH2 CELLS;

EID: 20044386003     PISSN: 00414301     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Naclerio RM. Allergic rhinitis. N Engl J Med 1991; 325: 860-869.
2. Skoner DP. Allergic rhinitis: definition, epidemiology, pathophysiology, detection and diagnosis. J Allergy Clin Immunol 2001; 108. S2-S8.
3. Naclerio RM, Proud D, Togias AG, et al. Inflammatory mediators in late antigen-induced rhinitis. N Engl J Med 1985; 313: 65-70.
4. Mosmann TR, Sad S. The expanding universe of T-cell subsets: Th1, Th2 and more. Immunol Today 1996; 17: 138-146.
5. Fiorentino DF, Zlotnik A, Mosman TR, Howard M, O'Garra A. IL-10 inhibits cytokine production by activated macrophages. J Immunol 1991; 147: 3815-3822.
6. De Wall Malefyt R, Abrams J Bennett B, Figdor CG, De Vries JE. Interleukin 10 (IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J Exp Med 1991; 174: 1209-1220.
7. Belinghausen I, Knop J, Saloga J. The role of interleukin 10 in the regulation of allergic immune responses. Int Arch Allergy Immunol 2001; 126: 97-101.
8. Takanashi S, Hasegawa Y, Kanehira Y, et al. Interleukin-10 level in sputum is reduced in bronchial asthma, COPD and in smokers. Eur Respir J 1999; 14: 309-314.
9. Lippert U, Moller A, Welker P, Artuc M, Henz BM. Inhibition of cytokine secretion from human leukemic mast cells and basophils by H1- and H2-receptor antagonists. Exp Dermatol 2000; 9: 118-124.
10. Kaminuma O, Ogawa K, Kikkawa H, Kikuchi M, Naito K, Ikezawa K. A novel anti-allergic drug, betotastine besilate, suppresses interleukin-5 production by human peripheral blood mononuclear cells. Biol Pharm Bull 1998; 21: 411-413.
11. Benlounes N, Dupyont C, Candalh C, Blaton M-A, Bloom M, Heyman M. Effect of terfenadine on TNF-α release from peripheral blood mononuclear cells during cow's milk allergy. Clin Exp Allergy 1997; 27: 942-948.
12. Charlesworth EN, Massey WA, Kagey-Sobotka A, Norman PS, Lichtenstein LM. Effects of H1 receptor blockade on the early and late response to cutaneous lallergen challenge. J Pharmacol Exp There 1992; 262: 964-970.
13. Mincarini M, Cagnoni F, Canonica GW, et al. Quantitative flow cytometric analysis of the effects of cetirizine on the expression of ICAM-1/CD54 on primary cultured nasal cells. Allergy 2000; 55: 226-231.
14. Jin Hr, Okamoto Y, Matsuzaki Z, Endo S, Ito E. Cetirizine decreases interleukin-4, interleukin-5, and interferon-gama gene expressions in nasal-associated lymphoid tissue of sensitized mice. Am J Rhinol 2002; 16: 43-48.
15. Arnold R, Rhioux J, Konig W. Cetirizine counter-regulates interleukin-8 release from human epithelial cells (A549). Clin Exp Allergy 1999; 29: 1593-1596.
16. Townley RG, Okada C. Use of cetirizine to investigate non-H1 effects of second-generation antihistamines. Ann Allergy 1992; 68: 190-196.
17. Simons FE. Prospective, long-term safety evaluation of the H1-receptor antagonist cetirizine in very young children with atopic dermatitis. ETAC study Group. Early Treatment of the Atopic Child. J Allergy Clin Immunol 1999; 104: 433-440.
18. Mansmann HC Jr, Altman RA, Berman BA, et al. Efficacy and safety of cetirizine therapy in perennial allergic rhinitis. Am Allergy 1992; 68: 348-353.
19. Noonan MJ, Raphael GD, Nayak A, et al. The health-related quality of life effects of once-daily cetirizine HCL in patients with seasonal allergic rhinitis: a randomized double-blind, placebo-controlled trial. Clin Exp Allergy 2003; 33: 351-358.
20. Kalayci O, Saraçlar Y, Adalioǧlu G, Sekerel B, Tuncer A. The effect of cetirizine on sulfidoleukotriene production by blood leukocytes in children with allergic rhinitis. Allergy 1995; 50: 964-969.
21. Romagnani S. Lymphokine production by human T cells in disease states. Annu Rev Immunol 1994; 12: 227-257.
22. + cells in human allergic diseases. J Allergy Clin Immunol 1997; 100: 1-6.
23. Hsu DH, Moore KW, Spits H. Differential effects of IL-4 and IL-10 on IL-2-induced IFN-gamma synthesis and lymphokine-activated killer activity. Int Immunol 1992; 4: 563-569.