메뉴 건너뛰기




Volumn 18, Issue 3, 2005, Pages 205-210

The antiphospholipid syndrome: Clinical characteristics, laboratory features and pathogenesis

Author keywords

Antiphospholipid antibodies; Antiphospholipid syndrome; Atherosclerosis; Lupus anticoagulants; 2 glycoprotein I

Indexed keywords

BETA2 GLYCOPROTEIN 1; LUPUS ANTICOAGULANT; PHOSPHOLIPID ANTIBODY;

EID: 20044384361     PISSN: 09517375     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.qco.0000168379.01272.53     Document Type: Review
Times cited : (20)

References (37)
  • 1
    • 0141517177 scopus 로고    scopus 로고
    • Current status and implications of autoimmune antiphospholipid antibodies in relation to thrombotic complications
    • Arnout J, Vermylen J. Current status and implications of autoimmune antiphospholipid antibodies in relation to thrombotic complications. J Thromb Haemostas 2003; 1:931-942.
    • (2003) J Thromb Haemostas , vol.1 , pp. 931-942
    • Arnout, J.1    Vermylen, J.2
  • 2
    • 3242671255 scopus 로고    scopus 로고
    • Antiphospholipid antibodies: Update on detection, pathophysiology and treatment
    • de Groot PhG, Derksen RHWM. Antiphospholipid antibodies: Update on detection, pathophysiology and treatment. Curr Opin Haematol 2004; 11:165-169. Includes a discussion on the latest opinions on treatment of APS patients.
    • (2004) Curr Opin Haematol , vol.11 , pp. 165-169
    • De Groot, Ph.G.1    Derksen, R.H.W.M.2
  • 3
    • 0033512274 scopus 로고    scopus 로고
    • International consensus statement on preliminary classification criteria for definite antiphospholipid syndrome: Report of an international workshop
    • Wilson WA, Gharavi AE, Koike T, et al. International consensus statement on preliminary classification criteria for definite antiphospholipid syndrome: report of an international workshop. Arthritis Rheum 1999; 42:1309-1311.
    • (1999) Arthritis Rheum , vol.42 , pp. 1309-1311
    • Wilson, W.A.1    Gharavi, A.E.2    Koike, T.3
  • 6
    • 7044223470 scopus 로고    scopus 로고
    • Beta2-Glycoprotein I-dependent lupus anticoagulant highly correlates with thrombosis in the antiphospholipid syndrome
    • de Laat HB, Derksen RH, Urbanus RT, et al. beta2-Glycoprotein I-dependent lupus anticoagulant highly correlates with thrombosis in the antiphospholipid syndrome. Blood 2004; 104:3598-3602. Showed the clinical importance of anti-β2GPI antibodies with LAC activity.
    • (2004) Blood , vol.104 , pp. 3598-3602
    • De Laat, H.B.1    Derksen, R.H.2    Urbanus, R.T.3
  • 7
    • 0037370733 scopus 로고    scopus 로고
    • Lupus anticoagulants are stronger risk factors for thrombosis than anticardiolipin antibodies in the antiphospholipid syndrome: A systematic review of the literature
    • Galli M, Luciani D, Bertolini G, Barbui T. Lupus anticoagulants are stronger risk factors for thrombosis than anticardiolipin antibodies in the antiphospholipid syndrome: a systematic review of the literature. Blood 2003; 101:1827-1832.
    • (2003) Blood , vol.101 , pp. 1827-1832
    • Galli, M.1    Luciani, D.2    Bertolini, G.3    Barbui, T.4
  • 8
    • 9144243607 scopus 로고    scopus 로고
    • Heparin prevents antiphospholipid antibody-induced fetal loss by inhibiting complement activation
    • Girardi G, Redecha P, Salmon JE. Heparin prevents antiphospholipid antibody-induced fetal loss by inhibiting complement activation. Nat Med 2004; 10:1222-1226. Very interesting paper on the relation between complement activation and pregnancy morbidity.
    • (2004) Nat Med , vol.10 , pp. 1222-1226
    • Girardi, G.1    Redecha, P.2    Salmon, J.E.3
  • 9
    • 7044236943 scopus 로고    scopus 로고
    • Anti-beta2-glycoprotein I antibodies: When and how should they be measured?
    • Reber G, de Moerloose P. Anti-beta2-glycoprotein I antibodies: when and how should they be measured? Thromb Res 2004; 114:527-531.
    • (2004) Thromb Res , vol.114 , pp. 527-531
    • Reber, G.1    De Moerloose, P.2
  • 10
    • 0141958839 scopus 로고    scopus 로고
    • Anti-β2-glycoprotein I, antiprothrombin antibodies, and the risk of thrombosis in the antiphospholipid syndrome
    • Galli M, Luciani D, Bertolini G, Barbui T. Anti-β2-glycoprotein I, antiprothrombin antibodies, and the risk of thrombosis in the antiphospholipid syndrome. Blood 2003; 102:2717-2723.
    • (2003) Blood , vol.102 , pp. 2717-2723
    • Galli, M.1    Luciani, D.2    Bertolini, G.3    Barbui, T.4
  • 11
    • 13244292209 scopus 로고    scopus 로고
    • Proposals for the measurement of anti-beta2-glycoprotein I antibodies: Standardization group of the European Forum on Antiphospholipid Antibodies
    • Reber G, Tincani A, Sanmarco M, et al. Proposals for the measurement of anti-beta2-glycoprotein I antibodies: standardization group of the European Forum on Antiphospholipid Antibodies. J Thromb Haemost 2004; 2:1860-1862. A balanced proposal on how to perform an anti-β2GPI antibody ELISA.
    • (2004) J Thromb Haemost , vol.2 , pp. 1860-1862
    • Reber, G.1    Tincani, A.2    Sanmarco, M.3
  • 12
    • 0042832999 scopus 로고    scopus 로고
    • Prevalence and clinical correlations of antibodies against six beta2-glycoprotein-I-related peptides in the antiphospholipid syndrome
    • Shoenfeld Y, Krause I, Kvapil F, et al. Prevalence and clinical correlations of antibodies against six beta2-glycoprotein-I-related peptides in the antiphospholipid syndrome. J Clin Immunol 2003; 23:377-383.
    • (2003) J Clin Immunol , vol.23 , pp. 377-383
    • Shoenfeld, Y.1    Krause, I.2    Kvapil, F.3
  • 13
    • 0037114142 scopus 로고    scopus 로고
    • Use of single point mutations in domain I of beta 2-glycoprotein I to determine fine antigenic specificity of antiphospholipid autoantibodies
    • Iverson GM, Reddel S, Victoria, et al. Use of single point mutations in domain I of beta 2-glycoprotein I to determine fine antigenic specificity of antiphospholipid autoantibodies. J Immunol 2002; 169:7097-7103.
    • (2002) J Immunol , vol.169 , pp. 7097-7103
    • Iverson, G.M.1    Reddel, S.2    Victoria3
  • 14
    • 13544276197 scopus 로고    scopus 로고
    • IgG antibodies that recognize epitope Gly40-Arg43 in domain I of beta2-glycoprotein I cause LAC and their presence correlates strongly with thrombosis
    • de Laat B, Derksen RH, Urbanus RT, de Groot PG. IgG antibodies that recognize epitope Gly40-Arg43 in domain I of beta2-glycoprotein I cause LAC and their presence correlates strongly with thrombosis. Blood 2005; 105:1540-1547. The relevant epitope for anti-β2GPI antibodies on β2GPI has been pinpointed on a positive cluster of amino acids on domain I of the protein. Correlations have been made between anti-β2GPI reactivity in an ELISA and LAC activity.
    • (2005) Blood , vol.105 , pp. 1540-1547
    • De Laat, B.1    Derksen, R.H.2    Urbanus, R.T.3    De Groot, P.G.4
  • 15
    • 0347381206 scopus 로고    scopus 로고
    • Systemic lupus erythematosus and accelerated atherosclerosis
    • Hahn BH. Systemic lupus erythematosus and accelerated atherosclerosis. N Engl J Med 2003; 349:2379-2380.
    • (2003) N Engl J Med , vol.349 , pp. 2379-2380
    • Hahn, B.H.1
  • 16
    • 13244278356 scopus 로고    scopus 로고
    • Premature atherosclerosis in primary antiphospholipid syndrome: Preliminary data
    • Ames PR, Margarita A, Sokoll KB, et al. Premature atherosclerosis in primary antiphospholipid syndrome: preliminary data. Ann Rheum Dis 2005; 64:315-317.
    • (2005) Ann Rheum Dis , vol.64 , pp. 315-317
    • Ames, P.R.1    Margarita, A.2    Sokoll, K.B.3
  • 17
    • 11144229526 scopus 로고    scopus 로고
    • Decreased binding of annexin v to endothelial cells: A potential mechanism in atherothrombosis of patients with systemic lupus erythematosus
    • Cederholm A, Svenungsson E, Jensen-Urstad K, et al. Decreased binding of annexin v to endothelial cells: a potential mechanism in atherothrombosis of patients with systemic lupus erythematosus. Arterioscler Thromb Vasc Biol 2005; 25:198-203.
    • (2005) Arterioscler Thromb Vasc Biol , vol.25 , pp. 198-203
    • Cederholm, A.1    Svenungsson, E.2    Jensen-Urstad, K.3
  • 18
    • 10444248119 scopus 로고    scopus 로고
    • LUMINA Study Group, Systemic lupus erythematosus in a multiethnic US cohort (LUMINA) XXIII: Baseline predictors of vascular events
    • Toloza SM, Uribe AG, McGwin G Jr, et al. LUMINA Study Group, Systemic lupus erythematosus in a multiethnic US cohort (LUMINA) XXIII: baseline predictors of vascular events. Arthritis Rheum 2004; 50:3947-3957.
    • (2004) Arthritis Rheum , vol.50 , pp. 3947-3957
    • Toloza, S.M.1    Uribe, A.G.2    McGwin Jr., G.3
  • 19
    • 3042717706 scopus 로고    scopus 로고
    • Antiphospholipid antibodies and atherosclerosis
    • Nicolo D, Monestier M. Antiphospholipid antibodies and atherosclerosis. Clin Immunol 2004; 112:183-189.
    • (2004) Clin Immunol , vol.112 , pp. 183-189
    • Nicolo, D.1    Monestier, M.2
  • 20
    • 2442417320 scopus 로고    scopus 로고
    • Suppression of early atherosclerosis in LDL-receptor deficient mice by oral tolerance with beta 2-glycoprotein I
    • George J, Yacov N, Breitbart E, et al. Suppression of early atherosclerosis in LDL-receptor deficient mice by oral tolerance with beta 2-glycoprotein I. Cardiovasc Res 2004; 62:603-609.
    • (2004) Cardiovasc Res , vol.62 , pp. 603-609
    • George, J.1    Yacov, N.2    Breitbart, E.3
  • 21
    • 0346030568 scopus 로고    scopus 로고
    • Prevalence and correlates of accelerated atherosclerosis in systemic lupus erythematosus
    • Roman MJ, Shanker BA, Davis A, et al. Prevalence and correlates of accelerated atherosclerosis in systemic lupus erythematosus. N Engl J Med 2003; 349:2399-2406.
    • (2003) N Engl J Med , vol.349 , pp. 2399-2406
    • Roman, M.J.1    Shanker, B.A.2    Davis, A.3
  • 22
    • 7044234648 scopus 로고    scopus 로고
    • The lupus anticoagulant is a risk factor for myocardial infarction (but not atherosclerosis): Hopkins Lupus Cohort
    • Petri M. The lupus anticoagulant is a risk factor for myocardial infarction (but not atherosclerosis): Hopkins Lupus Cohort. Thromb Res 2004; 114:593-595. Another excellent study on the correlation of atherosclerosis and aPLs.
    • (2004) Thromb Res , vol.114 , pp. 593-595
    • Petri, M.1
  • 23
    • 0030931521 scopus 로고    scopus 로고
    • The epitopes for some antiphospholipid antibodies are adducts of oxidized phospholipid and beta2 glycoprotein 1 (and other proteins)
    • Horkko S, Miller E, Branch DW, et al. The epitopes for some antiphospholipid antibodies are adducts of oxidized phospholipid and beta2 glycoprotein 1 (and other proteins). Proc Natl Acad Sci U S A 1997; 94:10356-10361.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 10356-10361
    • Horkko, S.1    Miller, E.2    Branch, D.W.3
  • 24
    • 0347763341 scopus 로고    scopus 로고
    • IgG autoantibodies against beta2-glycoprotein I complexed with a lipid ligand derived from oxidized low-density lipoprotein are associated with arterial thrombosis in antiphospholipid syndrome
    • Lopez D, Kobayasni K, Merrill JT, et al. IgG autoantibodies against beta2-glycoprotein I complexed with a lipid ligand derived from oxidized low-density lipoprotein are associated with arterial thrombosis in antiphospholipid syndrome. Clin Dev Immunol 2003; 10:203-211.
    • (2003) Clin Dev Immunol , vol.10 , pp. 203-211
    • Lopez, D.1    Kobayasni, K.2    Merrill, J.T.3
  • 25
    • 0036737909 scopus 로고    scopus 로고
    • Omega-carboxyl variants of 7-keto-cholesteryl esters are ligands for beta(2)-glycoprotein I and mediate antibody-dependent uptake of oxidized LDL by macrophages
    • Liu Q, Kobayashi K, Furukawa J, et al. Omega-carboxyl variants of 7-keto-cholesteryl esters are ligands for beta(2)-glycoprotein I and mediate antibody-dependent uptake of oxidized LDL by macrophages. J Lipid Res 2002; 43:1486-1495.
    • (2002) J Lipid Res , vol.43 , pp. 1486-1495
    • Liu, Q.1    Kobayashi, K.2    Furukawa, J.3
  • 26
    • 0035652560 scopus 로고    scopus 로고
    • Effect of cardiolipin oxidation on solid-phase immunoassay for antiphospholipid antibodies
    • Schlame M, Haller I, Sammaritano LR, Blanck TJ. Effect of cardiolipin oxidation on solid-phase immunoassay for antiphospholipid antibodies. Thromb Haemost 2001; 86:1475-1482.
    • (2001) Thromb Haemost , vol.86 , pp. 1475-1482
    • Schlame, M.1    Haller, I.2    Sammaritano, L.R.3    Blanck, T.J.4
  • 27
    • 1542373659 scopus 로고    scopus 로고
    • Antibodies to tissue-type plasminogen activator (tPA) in patients with antiphospholipid syndrome: Evidence of interaction between the antibodies and the catalytic domain of tPA in 2 patients
    • Cugno M, Cabibbe M, Galli M, et al. Antibodies to tissue-type plasminogen activator (tPA) in patients with antiphospholipid syndrome: evidence of interaction between the antibodies and the catalytic domain of tPA in 2 patients. Blood 2004; 103:2121-2126. Strong evidence that antibodies directed against tPA are of clinical relevance.
    • (2004) Blood , vol.103 , pp. 2121-2126
    • Cugno, M.1    Cabibbe, M.2    Galli, M.3
  • 28
    • 2342472560 scopus 로고    scopus 로고
    • Nicked beta2-glycoprotein I: A marker of cerebral infarct and a novel role in the negative feedback pathway of extrinsic fibrinolysis
    • Yasuda S, Atsumi T, Ieko M, et al. Nicked beta2-glycoprotein I: a marker of cerebral infarct and a novel role in the negative feedback pathway of extrinsic fibrinolysis. Blood 2004; 103:3766-3772. This article described elegantly how β92GPI can act as a negative regulator of fibrinolysis.
    • (2004) Blood , vol.103 , pp. 3766-3772
    • Yasuda, S.1    Atsumi, T.2    Ieko, M.3
  • 29
    • 0037169563 scopus 로고    scopus 로고
    • Heparin inhibits the binding of beta 2-glycoprotein I to phospholipids and promotes the plasmin-mediated inactivation of this blood protein: Elucidation of the consequences of the two biological events in patients with the anti-phospholipid syndrome
    • Guerin J, Sheng Y, Reddel S, et al. Heparin inhibits the binding of beta 2-glycoprotein I to phospholipids and promotes the plasmin-mediated inactivation of this blood protein: elucidation of the consequences of the two biological events in patients with the anti-phospholipid syndrome. J Biol Chem 2002; 277:2644-2649.
    • (2002) J Biol Chem , vol.277 , pp. 2644-2649
    • Guerin, J.1    Sheng, Y.2    Reddel, S.3
  • 30
    • 1642399591 scopus 로고    scopus 로고
    • Beta 2-Glycoprotein I binds factor XI and inhibits its activation by thrombin and factor XIIa: Loss of inhibition by clipped beta 2-glycoprotein I
    • Shi T, Iverson GM, Qi JC, et al. beta 2-Glycoprotein I binds factor XI and inhibits its activation by thrombin and factor XIIa: loss of inhibition by clipped beta 2-glycoprotein I. Proc Natl Acad Sci U S A 2004; 101:3939-3944. Describes a possible role of β92GPI in the regulation of contact activation induced coagulation.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 3939-3944
    • Shi, T.1    Iverson, G.M.2    Qi, J.C.3
  • 32
    • 0242349755 scopus 로고    scopus 로고
    • Sulfatides: Targets for anti-phospholipid antibodies
    • Merten M, Motamedy S, Ramamurthy S, et al. Sulfatides: targets for anti-phospholipid antibodies. Circulation 2003; 108:2082-2087.
    • (2003) Circulation , vol.108 , pp. 2082-2087
    • Merten, M.1    Motamedy, S.2    Ramamurthy, S.3
  • 33
    • 0037528699 scopus 로고    scopus 로고
    • Role of the MyD88 transduction signaling pathway in endothelial activation by antiphospholipid antibodies
    • Rascni E, Testoni C, Bosisio D, et al. Role of the MyD88 transduction signaling pathway in endothelial activation by antiphospholipid antibodies. Blood 2003; 101:3495-3500.
    • (2003) Blood , vol.101 , pp. 3495-3500
    • Rascni, E.1    Testoni, C.2    Bosisio, D.3
  • 34
    • 0034685886 scopus 로고    scopus 로고
    • High affinity binding of beta 2-glycoprotein I to human endothelial cells is mediated by annexin II
    • Ma K, Simantov R, Zhang JC, et al. High affinity binding of beta 2-glycoprotein I to human endothelial cells is mediated by annexin II. J Biol Chem 2000; 275:15541-15548.
    • (2000) J Biol Chem , vol.275 , pp. 15541-15548
    • Ma, K.1    Simantov, R.2    Zhang, J.C.3
  • 35
    • 0141445991 scopus 로고    scopus 로고
    • 2-glyco-protein I increase platelet deposition to collagen via interaction with phospholipids and the apolipoprotein E receptor 2′
    • 2-glyco-protein I increase platelet deposition to collagen via interaction with phospholipids and the apolipoprotein E receptor 2′. J Biol Chem 2003; 278:33831-33838.
    • (2003) J Biol Chem , vol.278 , pp. 33831-33838
    • Lutters, B.C.H.1    Derksen, R.H.W.M.2    Tekelenburg, W.L.3
  • 36
    • 13544259567 scopus 로고    scopus 로고
    • Binding of beta2-glycoprotein I to anionic phospholipids facilitates processing and presentation of a cryptic epitope that activates pathogenic autoreactive T cells
    • Kuwana M, Matsuura E, Kobayashi K, et al. Binding of beta2-glycoprotein I to anionic phospholipids facilitates processing and presentation of a cryptic epitope that activates pathogenic autoreactive T cells. Blood 2005; 105: 1552-1557. Very interesting study on how autoantibodies arise against β2GPI.
    • (2005) Blood , vol.105 , pp. 1552-1557
    • Kuwana, M.1    Matsuura, E.2    Kobayashi, K.3
  • 37
    • 0031594156 scopus 로고    scopus 로고
    • Anti-beta2 glycoprotein I antibodies and platelet activation in patients with antiphospholipid antibodies: Association with increased excretion of platelet-derived thromboxane urinary metabolites
    • Forastiero R, Martinuzzo M, Carreras LO, Maclouf J. Anti-beta2 glycoprotein I antibodies and platelet activation in patients with antiphospholipid antibodies: association with increased excretion of platelet-derived thromboxane urinary metabolites. Thromb Haemost 1998; 79:42-45.
    • (1998) Thromb Haemost , vol.79 , pp. 42-45
    • Forastiero, R.1    Martinuzzo, M.2    Carreras, L.O.3    Maclouf, J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.