Lajollamycin, a nitro-tetraene spiro-β-lactone-γ-lactam antibiotic from the marine actinomycete Streptomyces nodosus

Journal of Natural Products

Volumn 68, Issue 2, 2005, Pages 240-243

  Manam, Rama Rao ^a   Teisan, Sy ^a   White, Donald J ^a   Nicholson, Benjamin ^a   Grodberg, Jennifer ^a   Neuteboom, Saskia T C ^a   Lam, Kin S ^a   Mosca, Deborah A ^a   Lloyd, G Kenneth ^a   Potts, Barbara C M ^a  

^a Nereus Pharmaceuticals Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

16 METHYLOXAZOLOMYCIN; ANTIBIOTIC AGENT; GAMMA LACTAM DERIVATIVE; LACTONE DERIVATIVE; LAJOLLAMYCIN; NITRO DERIVATIVE; OXAZOLOMYCIN; SPIRO COMPOUND; TRIEDIMYCIN B; UNCLASSIFIED DRUG;

ACTINOBACTERIA; ANIMAL CELL; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL STRAIN; BACTERIOPLANKTON; CANCER CELL CULTURE; CANCER INHIBITION; CELL STRAIN BF16 F10; CONTROLLED STUDY; DRUG ISOLATION; DRUG STRUCTURE; GRAM POSITIVE BACTERIUM; MOUSE; NONHUMAN; SEDIMENT; SPECTROSCOPY; STREPTOMYCES; STREPTOMYCES NODOSUS; UNITED STATES;

ANIMALS; ANTI-BACTERIAL AGENTS; ANTINEOPLASTIC AGENTS; CALIFORNIA; CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; GRAM-POSITIVE BACTERIA; LACTAMS; MICE; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; OXAZOLES; POLYUNSATURATED ALKAMIDES; SPIRO COMPOUNDS; STREPTOMYCES;

EID: 20044379204     PISSN: 01633864     EISSN: None     Source Type: Journal    
DOI: 10.1021/np049725x     Document Type: Article

References (18)

1. Fenical, W.; Sethna, K. M.; Lloyd, G. K. Pharm. News 2002, 9, 489-494.
2. Shepard, F. P.; Dill, R. F. Submarine Canyons and Other Sea Valleys; Rand McNally: Chicago, 1966; pp 31-68.
3. Shepard, F. P. The Earth Beneath the Sea; The Johns Hopkins Press: Baltimore, 1967; pp 115-138.
4. Mori, T.; Takahashi, K.; Kashiwabara, M.; Lemura, D.; Iwadare, S.; Shizuri, Y.; Mitomo, R.; Nakano, F.; Matsuzaki, A. Tetrahedron Lett. 1985, 26, 1073-1076.
5. Ryu, G.; Hwang, S.; Kim, S. J. Antibiot. 1997, 50, 1064-1066.
6. Ikeda, Y.; Kondo, S.; Naganawa, H.; Hattori, S.; Hamada, M.; Takeuchi, T. J. Antibiot. 1991, 44, 453-455.
7. Descotes, G.; Bahurel, Y.; Bourillot, M.; Pingeon, G.; Rostaing, R. Bull. Soc. Chem. Fr. 1970, 282-289.
8. Siddiqueullah, M.; McGrath, R.; Vining, L. C. Can. J. Biochem. 1967, 45, 1881-1889.
9. Chang, C. J.; Floss, H. G.; Hook, D. J.; Mabe, J. A.; Manni, P. E.; Martin, L. L.; Schroder, K.; Shieh, T. L. J. Antibiot. 1981, 34, 555-566.
10. Baxter, R. L.; Hanley, A. B.; Chan, H. W. S.; Greenwood, S. L.; Abbot, E. M.; McFarlane, I. J.; Milne, K. J. Chem. Soc., Perkin Trans, 1 1992, 2495-2502.
11. Carter, G. T.; Nietsche, J. A.; Goodman, J. J.; Torrey, M. J.; Dunne, T. S.; Siegel, M. M.; Borders, D. B. J. Chem. Soc., Chem. Commun. 1989, 17, 1271-1273.
12. Arima, K.; Imanaka, H.; Kousaka, M.; Fukuda, A.; Tamura, G. J. Antibiot., Ser. A 1965, 18, 201-204.
13. Koyama, M.; Kodama, Y.; Tsuruoka, T.; Ezaki, N.; Niwa, T.; Inouye, S. J. Antibiot. 1981, 34, 1569-1576.
14. Kaneda, M.; Nakamuru, S.; Ezaki, N. J. Antibiot. 1981, 34, 1366-1368.
15. Rebstock, M. C.; Crooks, H. M.; Controulis, J.; Bartz, Q. R. J. Am. Chem. Soc. 1949, 71, 2458-2462.
16. Ganguly, A. K.; Sarre, O. Z.; Greeves, D.; Morton, J. J. Am. Chem. Soc. 1975, 97, 1982-1985.
17. Ganguly, A. K.; Saksena, A. K. J. Antibiot. 1975, 28, 707-709.
18. Ferraro, M. Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria that Grow Aerobically; Approved Standard (NCCLS); Villanova, 2000; Vol. M7-A5, pp 1-33.