The influence of water content of triglyceride oils on the solubility of steroids

Pharmaceutical Research

Volumn 22, Issue 5, 2005, Pages 784-788

  Land, Laura M ^a   Li, Ping ^b   Bummer, Paul Michael ^c  

^a PROCTER AND GAMBLE PHARMACEUTICALS   (United States)

^b NOVARTIS PHARMA AG   (Switzerland)

^c University of Kentucky   (United States)

Author keywords

Hydrates; Moisture content; Solubility; Steroids; Triglycerides

Indexed keywords

ESTRADIOL; PROGESTERONE; TESTOSTERONE; TRIACYLGLYCEROL;

ARTICLE; CRYSTALLIZATION; DRUG SOLUBILITY; HYDRATION; LIPOPHILICITY; PRIORITY JOURNAL; SOLUBILITY;

CHEMISTRY, PHARMACEUTICAL; CRYSTALLIZATION; EXCIPIENTS; PLANT OILS; SOLUBILITY; STEROIDS; TECHNOLOGY, PHARMACEUTICAL; TRIGLYCERIDES; TRITIUM; WATER;

EID: 20044374400     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11095-005-2595-6     Document Type: Article

References (22)

1. J. R. Robinson. Introduction: semi-solid formulations for oral drug delivery. Bulletin Technique Gattefosse 89:11-13 (1996).
2. A. J. Humberstone and W. N. Charman. Lipid-based vehicles for the oral delivery of poorly water-soluble drugs. Adv. Drug Del. Rev 25:103-128 (1997).
3. B. J. Aungst. Novel formulation strategies for improving oral bioavailability of drugs with poor membrane permeation or pre-systemic metabolism. J. Pharm. Sci. 82:979-987 (1993).
4. A. T. Serajuddin, P. C. Sheen, D. Mufson, D. F. Berstein, and M. A. Augustine. Effect of vehicle amphiphilicity on the dissolution and bioavailability of a poorly water-soluble drug from solid dispersion. J. Pharm. Sci. 77:414-417 (1988).
5. N. H. Shah, M. T. Carvajal, C. I. Patel, M. H. Infeld, and A. W. Malick. Self-emulsifying drug delivery systems (SEDDS) with polyglycolysed glycerides for improving in vitro dissolution and oral absorption of lipophilic drugs. Int. J. Pharm. 106:15-23 (1994).
6. R. A. Myers and V. Stella. Systemic bioavailability of penclomidine (NSC-338720) from oil-in-water emulsions administered intraduodenally to rats. Int. J. Pharm. 78:217-226 (1992).
7. R. A. Schwendener and H. Schott. Lipophilic1-beta-D-arabinofuranosyl cytosine derivatives in liposomal formulations for oral and parenteral antileukemic therapy in the murine L1210 leukemia model. J. Cancer Res. Clin. Oncol 122:723-726 (1996).
8. Y. Cao, M. Marra, and B. Anderson. Predictive relationships for the effects of triglyceride ester concentration and water uptake on solubility and partitioning of small molecules into lipid vehicles. J. Pharm. Sci. 93:2768-2779 (2004).
9. U. Jain, W. Higuchi, C. Liu, P. Lee, and N. Mazer. Cholesterol thermodynamic activity determinations in bile salt-lecithin-cholesterol systems and cholesterol-rich liquid crystalline mesophase formation. Pharm. Res. 9:792-799 (1992).
10. E. Shefter and T. Higuchi. Dissolution behavior of crystalline solvated and nonsolvated forms of some pharmaceuticals. J. Pharm. Sci. 52:781-791 (1963).
11. A. Thakkar and N. Hall. Micellar solubilization of testosterone III: dissolution behavior of testosterone in aqueous solutions of selected surfactants. J. Pharm. Sci. 58:68-71 (1969).
12. B. Haner and D. Norton. Crystal data. I. For some pregnenes and pregnadienes. Acta Crystallogr. 17:1610 (1964).
13. B. Jerslev, S. Frokjaer, and P. Thorbek. Organic solid phase analysis II. Two unexpected cases of pseudopolymorphism. Arch. Pharm. Chemi. Sci. Ed 9:123-130 (1981).
14. H. Fung and T. Higuchi. Molecular interactions and solubility of polar nonelectrolytes in nonpolar solvents. J. Pharm. Sci. 60: 1782-1788 (1971).
15. Y. Yamaoka, R. Roberts, and V. Stella. Low-melting phenytoin prodrugs as alternative oral delivery methods for phenytoin: a model for other high-melting sparingly water-soluble drugs. J. Pharm. Sci. 72:400-405 (1983).
16. B. K. Kang, J. S. Lee, S. K. Chon, S. Y. Jeong, S. H. Yuk, G. Khang, H. B. Lee, and S. H. Cho. Development of self-microemulsifying drug delivery systems (SMEDDS) for oral bioavailability enhancement of simvastatin in beagle dogs. Int. J. Pharm. 274:65-73 (2004).
17. C. Malcolmson, C. Satra, S. Kantaria, A. Sidhu, and M. J. Lawrence. Effect of oil on the level of solubilization of testosterone propionate into nonionic oil-in-water microemulsions. J. Pharm. Sci. 87:109-116 (1998).
18. T. R. Kommuru, B. Gurley, M. A. Khan, and I. K. Reddy. Self-emulsifying drug delivery systems (SEDDS) of coenzyme Q10: formulation development and bioavailability assessment. Int. J. Pharm. 212:233-246 (2001).
19. E. Lamcharfi, G. Kunesch, C. Meyer, and B. Robert. Investigation of cyclodextrin inclusion compounds using FT-IR and Raman spectroscopy. Spectrochimica Acta Part A 51:1861-1870 (1995).
20. F. Parker and K. Bhaskar. Self-association of cholesterol and its interaction with triglycerides. An IR study. Biochemistry 7:1286-1290 (1968).
21. H. Zhu and D. Grant. Influence of water activity in organic solvent + water mixtures on the nature of the crystallizing drug phase. 2. Ampicillin. Int. J. Pharm. 139:33-43 (1996).
22. J. De Smidt, J. Fokkens, H. Grijseels, and D. Crommelin. Dissolution of theophylline monohydrate and anhydrous theophylline in buffer solutions. J. Pharm. Sci. 75:497-501 (1986).