Use of mycophenolate mofetil for chronic, refractory immune cytopenias in children with autoimmune lymphoproliferative syndrome

British Journal of Haematology

Volumn 129, Issue 4, 2005, Pages 534-538

  Rao, V Koneti ^a   Dugan, Faith ^a   Dale, Janet K ^a   Davis, Joie ^b   Tretler, Jean ^a   Hurley, John K ^a   Fleisher, Thomas ^c   Puck, Jennifer ^b   Straus, Stephen E ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Autoimmune haemolytic anaemia; Autoimmune lymphoproliferative syndrome; Autoimmune neutropenia; Immune mediated thrombocytopenia; Mycophenolate mofetil

Indexed keywords

AZATHIOPRINE; CORTICOSTEROID; DEXAMETHASONE; FAS LIGAND; GRANULOCYTE COLONY STIMULATING FACTOR; HISTAMINE H2 RECEPTOR ANTAGONIST; IMMUNOGLOBULIN; IMMUNOGLOBULIN G; IMMUNOSUPPRESSIVE AGENT; IRON; MERCAPTOPURINE; METHYLPREDNISOLONE SODIUM SUCCINATE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISONE; RHESUS D ANTIBODY; RITUXIMAB;

ADOLESCENT; APOPTOSIS; ARTICLE; AUTOIMMUNE DISEASE; AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME; BLOOD CELL COUNT; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOPENIA; DOSE RESPONSE; DRUG DOSE REDUCTION; DRUG INDICATION; DRUG INDUCED HEADACHE; DRUG RESPONSE; EPIGASTRIC PAIN; ERYTHROCYTE TRANSFUSION; FOLLOW UP; GENE MUTATION; HUMAN; HYPERSPLENISM; IMMUNOGLOBULIN BLOOD LEVEL; INFANT; INFECTION; LYMPHADENOPATHY; LYMPHOCYTOPENIA; LYMPHOMA; LYMPHOPROLIFERATIVE DISEASE; MALE; PRIORITY JOURNAL; SIDE EFFECT; SPLENECTOMY; STEROID THERAPY; THROMBOCYTOPENIA; VIRUS LIKE ILLNESS;

ADOLESCENT; ANEMIA, HEMOLYTIC, AUTOIMMUNE; AUTOIMMUNE DISEASES; CHILD; CHILD, PRESCHOOL; FOLLOW-UP STUDIES; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INFANT; LEUKOCYTE COUNT; LYMPHOPROLIFERATIVE DISORDERS; MALE; MYCOPHENOLIC ACID; NEUTROPENIA; PAIN; PRODRUGS; THROMBOCYTOPENIA;

EID: 20044368060     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2005.05496.x     Document Type: Article

References (12)

1. Birkeland, S.A. & Hamilton-Dutoit, S. (2003) Is post transplant lymphoproliferative disorder (PTLD) caused by any specific immunosuppressive drug or by the transplantation per se? Transplantation, 76, 984-988.
2. Bolwell, B., Sobecks, R., Pohlman, B., Andresen, S., Rybicki, L., Kuczkowski, E. & Kalaycio, M. (2004) A prospective randomized trial comparing cyclosporine and short course methotrexate with cyclosporine and mycophenolate mofetil for GVHD prophylxis in myeloablative allogeneic bone marrow transplantation. Bone Marrow Transplantation, 34, 621-625.
3. Cooper, N., Stasi, R., Cunningham-Rundles, S., Feuerstein, M.A., Leonard, J.P., Amadori, S. & Bussel, J.B. (2004) The efficacy and safety of B cell depletion with anti-CD20 monoclonal antibody in adults with chronic immune thrombocytopenic purpura. British Journal of Hematology, 125, 232-239.
4. Holzelova, E., Vonarbourg, C., Stolzenberg, M.C., Arkwright, P.D., Selz, F., Prieur, A.M., Blanche, S., Bartunkova, J., Vilmer, E., Fischer, A., le Deist, F. & Rieux-Laucat, F. (2004) Autoimmune lymphoproliferative syndrome with somatic Fas mutations. New England Journal of Medicine, 351, 1409-1418.
5. Hou, M., Peng, J., Shi, Y., Zhang, C., Qin, P., Zhao, C., Ji, X., Wang, X. & Zhang, M. (2003) Mycophenolate mofetil (MMF) for the treatment of steroid resistant idiopathic thrombocytopenic purpura. European Journal of Hematology, 70, 353-357.
6. Howard, J., Hoffbrand, A.V., Prentice, H.G. & Mehta, A. (2002) Mycophenolate mofetil for the treatment of refractory autoimmune hasmolytic anemia and autoimmune thrombocytopenic purpura. British Journal of Hematology, 117, 712-715.
7. Jacqz-Aigrain, E., Khan Shaghaghi, E., Baudouin, V., Popon, M., Zhang, D., Maisin, A. & Loirat, C. (2000) Pharmacokinetics and tolerance of mycophenolate mofetil in renal transplant children. Pediatric Nephrology, 14, 95-99.
8. Mathew, T.H. (1998) A blinded, long-term, randomized multicenter study of mycophenolate mofetil in cadaveric renal transplantation: results at three years. Tricontinental Mycophenolate Mofetil Renal Transplantation Study Group. Transplantation, 65, 1450-1454.
9. McMillan, R. & Durette, C. (2004) Long term outcomes in adults with chronic ITP after splenectomy failure. Blood, 104, 956-960.
10. Puck, J.M. & Straus, S.E. (2004) Somatic mutations-not just for cancer anymore. New England Journal of Medicine, 351, 1388-1390.
11. Sneller, M.C., Wang, J., Dale, J.K., Strober, W., Middelton, L.A., Choi, Y., Fleisher, T.A., Lim, M.S., Jaffe, E.S., Puck, J.M., Lenardo, M.J. & Straus, S.E. (1997) Clinical, immunologic, and genetic features of an autoimmune lymphoproliferative syndrome associated with abnormal lymphocyte apoptosis. Blood, 89, 1341-1348.
12. Straus, S.E., Jaffe, E.S., Puck, J.M., Dale, J.K., Elkon, K.B., Rosen-Wolff, A., Peters, A.M., Sneller, M.C., Hallahan, C.W., Wang, J., Fischer, R.E., Jackson, C.M., Lin, A.Y., Baumler, C., Siegert, E., Marz, A., Vaishnaw, A.K., Grodsicky, T., Fleisher, T.A. & Lenardo, M.J. (2001) The development of lymphomas in families with autoimmune lymphoproliferative syndrome (ALPS) with germline Fas mutations and defective lymphocyte apoptosis. Blood, 98, 194-200.