Psychostimulants and G tolerance in rhesus monkeys: Effects of oral modafinil and injected caffeine

Aviation Space and Environmental Medicine

Volumn 76, Issue 2, 2005, Pages 121-126

  Florence, Geneviève ^a   Riondet, Laurent ^a   Serra, André ^a   Etienne, Xavier ^a   Huart, Bruno ^a   Van Beers, Pascal ^a   Bonneau, Dominique ^a   Gomez Merino, Danièle ^a   Drogou, Catherine ^a   Pradeau, Pascal ^a  

^a Institut de Medecine Aerospatiale du Service de Sante des Armees   (France)

Author keywords

Acceleration; EEG; Endpoint; Primate; Psychostimulant

Indexed keywords

BENZOIC ACID; CAFFEINE; MODAFINIL; PSYCHOSTIMULANT AGENT; SOLVENT;

ACCELERATION; AIRPLANE PILOT; ANIMAL EXPERIMENT; ARTICLE; BRAIN BLOOD FLOW; CENTRIFUGATION; CONSCIOUSNESS; CONTROLLED STUDY; DRUG EFFECT; ELECTRIC ACTIVITY; ELECTROCARDIOGRAM; ELECTROCORTICOGRAPHY; FATIGUE; INJECTION; MALE; NONHUMAN; PLASMA OSMOLALITY; RHESUS MONKEY; STRESS;

ACCELERATION; AEROSPACE MEDICINE; ANIMALS; BENZHYDRYL COMPOUNDS; CAFFEINE; CENTRAL NERVOUS SYSTEM STIMULANTS; CENTRIFUGATION; CEREBRAL CORTEX; ELECTROENCEPHALOGRAPHY; ELECTROOCULOGRAPHY; FATIGUE; HYPERGRAVITY; MACACA MULATTA; MALE; STATISTICS, NONPARAMETRIC; UNCONSCIOUSNESS;

ANIMALIA; MACACA MULATTA; PRIMATES;

EID: 19944430145     PISSN: 00956562     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Arnaud MJ. The pharmacology of caffeine. Prog Drug Res 1987; 31:273-313.
2. Brierley JB, Brown AW, Excell B, et al. Brain damage in the rhesus monkey resulting from profound arterial hypotension. 1. Its nature, distribution and general physiological correlates. Brain Res 1969; 13:68-100.
3. Caldwell JA, Caldwell JL, Smythe NK, et al. A double-blind, placebo-controlled investigation of the efficacy of modafinil for sustaining the alertness and performance of aviators: a helicopter simulator study. Psychopharmacology 2000; 150:272-82.
4. Dill DB, Costill DL. Calculation of percentage changes in volumes of blood, plasma, and red cells in dehydration. J Appl Physiol 1974; 37:247-8.
5. Duteil J, Rambert FA, Pessonnier J, et al. Central alpha1-adrenergic stimulation in relation to the awakening activity of modafinil: behavioural studies in laboratory animals. Eur J Pharmacol 1990; 180:49-58.
6. Favre JB, Ravussin P, Chiolero R, et al. Liquides hypertoniques et pression intra-crânienne. Schweiz Med Wochenschr 1996; 126: 1635-43.
7. Florence G, Bonnier R, Plagnes D, et al. Effect of modafinil on cerebral blood flow of anaesthetized rats. Comparison with amphetamine. Exp Brain Res 2000; 135:552-6.
8. Fredholm BB, Bättig K, Holmen JN, et al. Actions of caffeine in the brain with special reference to factors that contribute to its widespread use. Pharmacol Rev 1999; 51:83-133.
9. Heiss WD. Flow thresholds of functional and morphological damage of brain tissue. Stroke 1983; 14:329-31.
10. Hermant JF, Rambert FA, Duteil J. Awakening properties of modafinil: effect on nocturnal activity in monkeys (Macaca mulatta) after acute and repeated administration. Psychopharmacology 1991; 103:28-32.
11. Howell LL. Effects of caffeine on ventilation during acute and chronic nicotine administration in rhesus monkeys. J Pharmacol Exp Ther 1995; 278:1085-94.
12. Lorist MM, Tops M. Caffeine, fatigue, and cognition. Brain Cogn 2003; 53:82-94.
13. Paul MA, Pigeau RA, Weinberg H. CC130 pilot fatigue during re-supply missions to former Yugoslavia. Aviat Space Environ Med 2001; 72:965-73.
14. Spealman RD. Psychomotor stimulant effects of methylxanthines in squirrel monekys: relation to adenosine antagonism. Psychopharmacology 1988; 95:19-24.
15. Z exposures of rats [Abstract]. Aviat Space Environ Med 1998; 69:241.
16. Wisor JP, Nishino S, Sora I, et al. Dopaminergic role in stimulant-induced wakefulness. J Neurosci 2001; 21:1787-94.
17. Florence G, Bonnier R, Riondet L, et al. Cerebral cortical blood flow during loss of consciousness induced by gravitational stress in rhesus monkeys. Neurosci Lett 2001; 305:99-102.