Systematic screening for mutations in the human N-methyl-D-aspartate 1 gene in schizophrenic patients from the German population

Psychiatric Genetics

Volumn 14, Issue 4, 2004, Pages 233-234

  Paus, Sebastian ^a   Rietschel, Marcelia ^a,b   Schulze, Thomas G ^a,b   Ohlraun, Stephanie ^a,b   Diaconu, Carmen C ^c   Van Den Bogaert, Ann ^d   Maier, Wolfgang ^a   Propping, Peter ^a   Cichon, Sven ^a,d   Nöthen, Markus M ^a,d  

^a UNIVERSITY OF BONN   (Germany)

^b CENTRAL INSTITUTE OF MENTAL HEALTH   (Germany)

^c STEFAN S NICOLAU INSTITUTE OF VIROLOGY   (Romania)

^d UNIVERSITY OF ANTWERP   (Belgium)

Author keywords

Glutamate receptor; NMDAR1; Schizophrenia; Single nucleotide polymorphism

Indexed keywords

GENOMIC DNA; GLUTAMATE RECEPTOR 1; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; RECEPTOR SUBUNIT;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DNA SEQUENCE; GENE; GENE MUTATION; GENETIC SCREENING; GENETIC VARIABILITY; GENOTYPE; GERMANY; HUMAN; NMDAR1 GENE; PRIORITY JOURNAL; SCHIZOPHRENIA; SINGLE NUCLEOTIDE POLYMORPHISM; SINGLE STRAND CONFORMATION POLYMORPHISM;

EID: 19944429753     PISSN: 09558829     EISSN: None     Source Type: Journal    
DOI: 10.1097/00041444-200412000-00013     Document Type: Article

References (20)

1. Begni S, Moraschi S, Bignotti S, Fumagalli F, Rillosi L, Perez J, et al. (2003). Association between the G1001C polymorphism in the GRIN1 gene promoter region and schizophrenia. Biol Psychiatry 53: 617-619.
2. Chumakov I, Blumenfeld M, Guerassimenko O, Cavarec L, Palicio M, Abderrahim H, et al. (2002). Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia. Proc Natl Acad Sci USA 99:13675-13680.
3. Hammond L, Castanotto D, Rice SR, Nimgaonkar VL, Wirshing DA, Rossi JJ, et al. (2002). Alteration of branch site consensus sequence and enhanced pre-mRNA splicing of an NMDAR1 intron not associated with schizophrenia. Am J Med Genet 114:631-636.
4. Harrison PJ, McLaughlin D, Kerwin RW (1991). Decreased hippocampal expression of a glutamate receptor gene in schizophrenia. Lancet 337:450-452.
5. Hung CC, Chen HY, Chen CH (2002). Systematic mutation analysis of the human glutamate receptor, ionotropic, N-methyl-D-aspartate 1 gene (GRIN1) in schizophrenic patients. Psychiatr Genet 12:225-230.
6. Javitt DC, Zukin SR (1991). Recent advances in the phencyclidine model of schizophrenia. Am J Psychiatry 148:1301-1308.
7. Malhotra A (1997). Park City Molecular Psychiatry Conference, Feb 2-4 1997. Meeting Report. Psych Genet 7:53-56.
8. Martucci L, Wong AH, Trakalo J, Gate-Carter T, Wong GW, Macciardi FM, et al. (2003). N-methyl-D-aspartate receptor NR1 subunit gene (GRIN1) in schizophrenia: TDT and case-control analyses. Am J Med Genet 119:24-27.
9. Mohn AR, Gainetdinov RR, Caron MG, Koller BH (1999). Mice with reduced NMDA receptor expression display behaviors related to schizophrenia. Cell 98:427-436.
10. Rice SR, Niu N, Berman DB, Heston LL, Sobell JL (2001). Identification of single nucleotide polymorphisms (SNPs) and other sequence changes and estimation of nucleotide diversity in coding and flanking regions of the NMDAR1 receptor gene in schizophrenic patients. Mol Psychiatry 6:274-284.
11. Sakurai K, Toru M, Yamakawa-Kobayashi K, Arinami T (2000). Mutation analysis of the N-methyl-D-aspartate receptor NR1 subunit gene (GRIN1) in schizophrenia. Neurosci Lett 296:168-170.
12. Schumacher J, Abou Jamra R, Freudenberg J, Becker T, Ohlraun S, Otte ACJ, et al. (2004). Examination of G72 and D-amino acid oxidase as genetic risk factors for schizophrenia and bipolar affective disorder. Mol Psychiatry 9:203-207.
13. Stefansson H, Sigurdsson E, Steinthorsdottir V, Bjornsdottir S, Sigmundsson T, Ghosh S, et al. (2002). Neuregulin 1 and susceptibility to schizophrenia. Am J Hum Genet 71:877-892.
14. Stefansson H, Sarginson J, Kong A, Yates P, Steinthorsdottir V, Gudfinnsson E, et al. (2003). Association of neuregulin 1 with schizophrenia confirmed in a Scottish population. Am J Hum Genet 72:83-87.
15. Tamminga CA (1998). Schizophrenia and glutamatergic transmission. Crit Rev Neurobiol 12:21-36.
16. Tang JX, Chen WY, He G, Zhou J, Gu NF, Feng GY, et al. (2004). Polymorphisms within 5′ end of the Neuregulin 1 gene are genetically associated with schizophrenia in the Chinese population. Mol Psychiatry 9:11-12.
17. Tani A, Kikuta R, Itoh K, Joo A, Shibata H, Ninomiya H, et al. (2002). Polymorphism analysis of the upstream region of the human N-methyl-D-aspartate receptor subunit NR1 gene (GRIN1): implications for schizophrenia. Schizophr Res 58:83-86.
18. Williams NM, Bowen T, Spurlock G, Norton N, Williams HJ, Hoogendoorn B, et al. (2002). Determination of the genomic structure and mutation screening in schizophrenic individuals for five subunits of the N-methyl-D-aspartate glutamate receptor. Mol Psychiatry 7:508-514.
19. Williams NM, Preece A, Spurlock G, Norton N, Williams HJ, Zammit S, et al. (2003). Support for genetic variation in neuregulin 1 and susceptibility to schizophrenia. Mol Psychiatry 8:485-487.
20. Yang JZ, Si TM, Ruan Y, Ling YS, Han YH, Wang XL, et al. (2003). Association study of neuregulin 1 gene with schizophrenia. Mol Psychiatry 8: 706-709.