Upregulation of connexin43 gap junctions between neointimal smooth muscle cells

European Journal of Cell Biology

Volumn 83, Issue 10, 2004, Pages 521-530

  Plenz, Gabriele ^a,b   Ko, Yu Shien ^c,d   Yeh, Hung I ^c   Eschert, Heike ^a,b   Sindermann, Jürgen R ^a,b   Dorszewski, Anja ^a,b   Hofnagel, Oliver ^a   Robenek, Horst ^a   Breithardt, Günther ^a,b   Severs, Nicholas J ^c  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b UNIVERSITY HOSPITAL MÜNSTER   (Germany)

^c ROYAL BROMPTON HOSPITAL   (United Kingdom)

^d MACKAY MEMORIAL HOSPITAL   (Taiwan)

Author keywords

Experimental restonosis; Macrophage; Response to injury

Indexed keywords

CONNEXIN 43; MESSENGER RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA STENOSIS; ARTERY INJURY; ARTERY INTIMA PROLIFERATION; ARTICLE; CELL JUNCTION; CHOLESTEROL DIET; CHOLESTEROL INTAKE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; ELECTRON MICROSCOPY; HISTOLOGY; HISTOPATHOLOGY; IMMUNOFLUORESCENCE MICROSCOPY; IN SITU HYBRIDIZATION; LASER MICROSCOPY; MACROPHAGE; MALE; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RABBIT; RESTENOSIS; SMOOTH MUSCLE FIBER; UPREGULATION; VASCULAR SMOOTH MUSCLE;

ANIMALIA; ORYCTOLAGUS CUNICULUS;

EID: 19944429524     PISSN: 01719335     EISSN: None     Source Type: Journal    
DOI: 10.1078/0171-9335-00417     Document Type: Article

References (23)

1. Alves, L. A., Coutinho-Silva, R., Persechini, P. M., Spray, D. C., Savino, W., De Carvalho, A. C.C., 1996. Are there functional gap junctions or junctional hemichannels in macrophages. Blood 88, 328-334.
2. Beyer, E. C., Steinberg, T. H., 1991. Evidence that the gap junction protein connexin-43 is the ATP-induced pore of mouse macrophages. J. Biol. Chem. 266, 7971-7974.
3. Blackburn, J. P., Connat, J. L., Severs, N. J., Green, C. R., 1997. Connexin43 gap junction levels during development of the thoracic aorta are temporally correlated with elastic laminae deposition and increased blood pressure. Cell Biol. Int. 21, 87-97.
4. Blackburn, J. P., Peters, N. S., Yeh, H. I., Rothery, S., Green, C. R., Severs, N. J., 1995. Upregulation of connexin43 gap junctions during early stages of human coronary atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 15, 1219-1228.
5. Cai, W. J., Koltai, S., Kocsis, E., Scholz, D., Schaper, W., Schaper, J., 2001. Connexin37, not Cx40 and Cx43, is induced in vascular smooth muscle cells during coronary arteriogenesis. J. Mol. Cell. Cardiol. 33, 957-967.
6. Eugenin, E. A., Branes, M. C., Berman, J. W., Saez, J. C., 2003. TNF-alpha plus IFN-gamma induce connexin43 expression and formation of gap junctions between human monocytes/macrophages that enhance physiological responses. J. Immunol. 170, 1320-1328.
7. Ferns, G. A., Reidy. M. A., Ross, R., 1991. Balloon catheter de-endothelialization of the nude rat carotid. Response to injury in the absence of functional T lymphocytes. Am. J. Pathol. 138, 1045-1057.
8. Gonzalez H. E., Eugenin E. A., Garces G., Solis N., Pizarro M., Accatino L., Saez J. C. 2002. Regulation of hepatic connexins in cholestasis: possible involvement of Kupffer cells and inflammatory mediators. Am. J. Physiol. Gastrointest. Liver Physiol. 282, G991-G1001.
9. Ko, Y S., Coppen, S. R., Dupont, E., Rothery, S., Severs. N. J., 2001. Regional differentiation of desmin, connexin43, and connexin45 expression patterns in rat aortic smooth muscle. Arterioscler. Thromb. Vasc. Biol. 21, 355-364.
10. Ko, Y. S., Plenz, G., Robenek, H., Severs, N. J., 1999a. Inverse relationship between connexin43 and desmin expression in cultured porcine aortic smooth muscle cells. Eur. J. Cell Biol. 78, 605-613.
11. Ko, Y. S., Yeh, H. I., Haw, M., Dupont, E., Kaba, R., Plenz, G., Robenek, H., Severs, N. J., 1999b. Differential expression of connexin43 and desmin defines two subpopulations of medial smooth muscle cells in the human internal mammary artery. Arterioscler. Thromb. Vasc. Biol. 19, 1669-1680.
12. Kwak, B. R., Mulhaupt, F., Veillard, N., Gros, D. B., Mach, F., 2002. Altered pattern of vascular connexin expression in atherosclerotic plaques. Arterioscler. Thromb. Vasc. Biol. 22, 225-230.
13. Muller, D. W., Ellis, S. G., Topol, E. J., 1992. Experimental models of coronary artery restenosis [published erratum appears in J. Am. Coll. Cardiol. 1992; 19, 1678]. J. Am. Coll. Cardiol. 19, 418-432.
14. Navab, M., Liao, F., Hough, G. P., Ross, L. A., van Lenten, B. J., Rajavashisth, T. B., Lusis, A. J., Laks, H., Drinkwater, D. C., Fogelman. A. M., 1991. Interaction of monocytes with cocultures of human aortic wall cells involves interleukins 1 and 6 with marked increases in connexin43 message. J. Clin. Invest. 87, 1763-1772.
15. Plenz, G., Dorszewski, A., Breithardt, G., Robenck, H., 1999. Expression of type VIII collagen after cholesterol diet and injury in the rabbit model of atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 19, 1201-1209.
16. Plenz, G., Koenig, C., Severs, N. J., Robenek, H., 1997. Smooth muscle cells express granulocyte-macrophage colony-stimulating factor in the undiseased and atherosclerotic human coronary artery. Arterioscler. Thromb. Vasc. Biol. 17, 2489-2499.
17. Polacek, D., Bech, F., McKinsey, J. F., Davies, P. F., 1997. Connexin43 gene expression in the rabbit arterial wall: effects of hypercholesterolemia, balloon injury and their combination. J. Vasc. Res. 34, 19-30.
18. Polacek, D., Lai, R., Volin, M. V., Davies, P. F., 1993. Gap junctional communication between vascular cells: Induction of connexin43 messenger RNA in macrophage foam cells of atherosclerotic lesions. Am. J. Pathol. 142, 593-606.
19. Rennick, R. E., Connat, J.-L., Burnstock, G., Rothery, S., Severs, N. J., Green, C. R., 1993. Expression of connexin43 gap junctions between cultured vascular smooth muscle cells is dependent upon phenotype. Cell Tissue Res. 271, 323-332.
20. Severs, N. J., 1999. Cardiovascular disease. Novartis. Found. Symp. 219, 188-206.
21. Severs, N. J., Dupont, E., Kaprielian. R. R., Yeh, H. I., Rothery, S., 1996. Gap junctions and connexins in the cardiovascular system, in: Yacoub, M. H., Carpentier. A., Pepper, J., Fabiani, J. (Eds.). Annual of Cardiac Surgery, 9th edition. Current Science, London, pp. 31-44.
22. van Kempen, M. J., Jongsma, H. J., 1999. Distribution of connexin37, connexin40 and connexin43 in the aorta and coronary artery of several mammals. Histochem. Cell Biol. 112, 479-486.
23. Yeh, H. I., Lupu, F., Dupont, E., Severs, N. J., 1997. Upregulation of connexin43 gap junctions between smooth muscle cells after balloon catheter injury in the rat carotid artery. Arterioscler. Thromb. Vasc. Biol. 17, 3174-3184.