Association of humoral immunity to human Hsp60 with the IL-6 gene polymorphism C-174G in patients with type 2 diabetes and controls

Hormone and Metabolic Research

Volumn 37, Issue 4, 2005, Pages 257-263

  Mostafazadeh, A ^a,b   Herder, C ^a   Haastert, B ^a   Hanifi Moghaddam, P ^a   Schloot, N ^a   Koenig, W ^c   Illig, T ^d   Thorand, B ^d   Holle, R ^d   Eslami, M B ^e   Kolb, Hubert ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b BABOL UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c UNIVERSITY OF ULM   (Germany)

^d INSTITUTE OF EPIDEMIOLOGY   (Germany)

^e TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Antibodies; Diabetes; Heat shock protein 60; Inflammation

Indexed keywords

ALBUMIN; C REACTIVE PROTEIN; CHOLESTEROL; HEAT SHOCK PROTEIN 60; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TUMOR NECROSIS FACTOR ALPHA; URIC ACID;

ADULT; AGE; AGED; ALLELE; ARTICLE; ATHEROSCLEROSIS; BLOOD PRESSURE; BODY MASS; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DISEASE ASSOCIATION; DNA POLYMORPHISM; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENDER; GENETIC ANALYSIS; HUMAN; HUMORAL IMMUNITY; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; PROMOTER REGION;

AGED; ANTIBODY FORMATION; AUTOANTIBODIES; CHAPERONIN 60; DIABETES MELLITUS, TYPE 2; DNA; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GENOTYPE; HUMANS; INTERLEUKIN-6; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC;

EID: 19944407903     PISSN: 00185043     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2005-861209     Document Type: Article

References (38)

1. Hightower LE. Heat shock, stress proteins, chaperones and proteotoxicity. Cell 1991; 66: 191-197
2. Kaufmann SHE. Heat shock proteins and the immune response. Immunol Today 1990; 11: 129-136
3. Young RA. Stress proteins and immunology. Annu Rev Immunol 1990; 8: 401-420
4. Chen W, Syldath U, Bellmann K, Burkart V, Kolb H. Human 60-kDa heat-shock protein: a danger signal to the innate immune system. J Immunol 1999; 162: 3212-3219
5. Kol A, Bounder T, Lichtman H, Libby P. Chlamydial and human heat shock protein 60s activate human vascular endothelium, smooth muscle cells, and macrophages. J Clin Invest 1999; 103: 571-577
6. Flohé SB, Brüggemann J, Lendemans S, Nikulina M, Meierhoff G, Flohé S, Kolb H. Human heat shock protein 60 induces maturation of dendritic cells versus a Th1-promoting phenotype. J Immunol 2003; 170: 2340-2348
7. Pickup JC, Crook MA. Is type II diabetes mellitus a disease of the innate immune system? Diabetologia 1998; 41: 1241-1248
8. Pradhan AD, Manson JE, Rifai N, Buring JE, Ridker PM. C-reactive protein, interleukin-6, and risk of developing type 2 diabetes mellitus. JAMA 2001; 286: 327-334
9. Müller S, Martin S, Koenig W, Hanifi-Moghaddam P, Rathmann W, Haastert B, Giani G, Illig T, Thorand B, Kolb H. Impaired glucose tolerance is associated with increased serum concentrations of interleukin 6 and co-regulated acute-phase proteins but not TNF-alpha or its receptors. Diabetologia 2002; 45: 805-812
10. Xu Q, Willeit J, Marosi M, Kleindienst R, Oberhollenzer F, Kiechl S, Stulnig T, Luef G, Wick G. Association of serum antibodies to heat-shock protein 65 with carotid atherosclerosis. Lancet 1993; 341: 255-259
11. Burian K, Kis Z, Virok D, Endresz V, Prohaszka Z, Duba J, Berencsi K, Boda K, Horvath L, Romics L, Fust G, Gonczol E. Independent and joint effects of antibodies to human heat-shock protein 60 and Chlamydia pneumoniae infection in the development of coronary atherosclerosis. Circulation 2001; 103: 1503-1508
12. Prohaszka Z, Duba J, Horvath L, Csaszar A, Karadi I, Szebeni A, Singh M, Fekete B, Romics L, Fust G. Comparative study on antibodies to human and bacterial 60 kDa heat shock proteins in a large cohort of patients with coronary heart disease and healthy subjects. Eur J Clin Invest 2001; 31: 285-292
13. Zhu J, Quyyumi AA, Rott D, Csako G, Wu H, Halcox J, Epstein SE. Antibodies to human heat-shock protein 60 are associated with the presence and severity of coronary artery disease: evidence for an autoimmune component of atherogenesis. Circulation 2001; 103: 1071-1075
14. Pockley AG. Heat shock proteins, inflammation, and cardiovascular disease. Circulation 2002; 105: 1012-1017
15. Kervinen H, Huittinen T, Vaarala O, Leinonen M, Saikku P, Manninen V, Manttari M. Antobodies to human heat shock protein 60, hypertension and dyslipidemia. A study of joint effects on coronary risk. Atherosclerosis 2003; 169: 339-344
16. Staub HL, Norman GL, Crowther T, da Cunha VR, Polanczyk A, Bohn JM, Fernandez JG, Chahade WH, von Muhlen CA. Antibodies to the atherosclerotic plaque components beta2-glycoprotein 1 and heat-shock proteins as risk factors for acute cerebral ischemia. Arq Neuropsiquiatr 2003; 61(3B): 757-763
17. Vozarova B, Fernández-Real JM, Knowler WC, Gallart L, Hanson RL, Gruber JD, Ricart W, Vendrell J, Richart C, Tataranni PA, Wolford JK. The interleukin-6 (-174) G/C promoter polymorphism is associated with type-2 diabetes mellitus in Native Americans and Caucasians. Hum Genet 2003; 112: 409-413
18. Illig T, Bongardt F, Schöpfer A, Müller-Scholze S, Rathmann W, Koenig W, Thorand B, Vollmert C, Holle R, Kolb H, Herder C and members of the KORA Group. Significant association of the interleukin-6 gene polymorphisms C-174G and A-598G with type 2 diabetes. J Clin Endocrinol Metab 2004; 89: 5053-5058
19. Rathmann W, Haastert B, Icks A, Lowel H, Meisinger C, Holle R, Giani G. High prevalence of undiagnosed diabetes mellitus in Southern Germany: Target populations for efficient screening. The KORA survey 2000. Diabetologia 2003; 46: 182-189
20. Rifai N, Tracy RP, Ridker PM. Clinical efficacy of an automated high-sensitivity C-reactive protein assay. Clin Chem 1999; 45: 2136-2141
21. Hoffmeister A, Rothenbacher D, Bazner U, Frohlich M, Brenner H, Hombach V, Koenig W. Role of novel markers of inflammation in patients with stable coronary heart disease. Am J Cardiol 2001; 87: 262-266
22. Illig T, Bongardt F, Schöpfer A, Holle R, Müller S, Rathmann W, Koenig W, Meisinger C, Wichmann HE, Kolb H, for the KORA Study Group. The endotoxin receptor TLR4 is not associated with diabetes or components of the metabolic syndrome. Diabetes 2003; 52: 2861-2864
23. Schmidt MI, Duncan BB, Sharrett AR, Lindberg G, Savage PJ, Offenbacher S, Azambuja MI, Tracy RP, Heiss G, for the ARIC Investigators. Markers of inflammation and prediction of diabetes mellitus in adults (Atherosclerosis Risk in Communities study): a cohort study. Lancet 1999; 153: 1649-1652
24. Festa A, D'Agostino R, Tracy RP, Haffner SM. Elevated levels of acute-phase proteins and plasminogen activator inhibitor-1 predict the development of type 2 diabetes. The Insulin Resistance Atherosclerosis Study. Diabetes 2002; 51: 131-1137
25. Hanson RL, Imperatore G, Bennett PH, Knowler WC. Components of the "metabolic syndrome" and incidence of type 2 diabetes. Diabetes 2002; 51: 3120-3127
26. Thorand B, Lowel H, Schneider A, Kolb H, Meisinger C, Frohlich M, Koenig W. C-reactive protein as a predictor for incident diabetes mellitus among middle-aged men: results from the MONICA Augsburg cohort study, 1984-1998. Arch Intern Med 2003; 163: 93-99
27. Humphries SE, Luong LA, Ogg MS, Hawe E, Miller GJ. The interleukin-6-174 G/C promoter polymorphism is associated with risk of coronary heart disease and systolic blood pressure in healthy men. Eur Heart J 2001; 22: 2243-2252
28. Brull DJ, Leeson CPM, Montgomery HE, Mullen M, de Divitiis M, Humphries SE, Deanfield JE. The effect of the interleukin-6-174G > C promoter gene polymorphism on endothelial function in healthy volunteers. Eur J Clin Invest 2002; 32: 53-157
29. Jenny NS, Tracy RP, Ogg MS, Luong le A, Kuller LH, Arnold AM, Sharrett AR, Humphries SE. In the elderly, interleukin-6 plasma levels and the -174G > C polymorphism are associated with the development of cardiovascular disease. Arterioscler Thromb Vasc Biol 2002; 22: 2066-2071
30. Jerrard-Dunne P, Sitzer M, Risley P, Steckel DA, Buehler A, von Kegler S, Markus HS. Carotid Atherosclerosis Progression Study Interleukin-6 promoter modulates the effects of heavy alcohol consumption on early carotid artery atherosclerosis: the Carotid Atherosclerosis Progression Study (CAPS). Stroke 2003; 34: 402-407
31. Fasshauer M, Klein J, Lossner U, Paschke R. Interleukin (IL)-6 mRNA expression is stimulated by insulin, isoproterenol, tumour necrosis factor alpha, growth hormone, and IL-6 in 3T3-L1 adipocytes. Horm Metab Res 2003; 35: 147-152
32. Veres A, Prohászka Z, Kilpinen S, Singh M, Füst G, Hurme M. The promoter polymorphism of the IL-6 gene is associated with levels of antibodies to 60-kDa heat-shock proteins. Immunogenetics 2002; 53: 851-856
33. Xu Q, Kleindienst R, Waitz W, Dietrich H, Wick G. Increased expression of heat shock protein 65 coincides with a population of infiltrating T lymphocytes in atherosclerotic lesions of rabbits specifically responding to heat shock protein 65. J Clin Invest 1993; 91: 2693-2702
34. Xu Q, Schett G, Seitz S, Hu Y, Gupta RS, Wick G. Surface staining and cytotoxic activity of heat shock protein 60 antibody on stressed aortic endothelial cells. Circ Res 1994; 75: 1078-1085
35. Schett G, Xu Q, Amberger A, van der Zee R, Recheis H, Willeit J, Wick G. Autoantibodies against heat shock protein 60 mediate endothelial cytotoxicity. J Clin Invest 1995; 96: 2569-2577
36. Schett G, Metzler B, Kleindienst R, Amberger A, Recheis H, Xu Q, Wick G. Myocardial injury leads to a release of heat shock protein (hsp) 60 and a suppression of the anti-hsp65 immune response. Cardiovasc Res 1999; 42: 685-695
37. Xu Q, Schett G, Perschinka H, Mayr M, Egger G, Oberhollenzer F, Willeit J, Kiechl S, Wick G. Serum soluble heat shock protein 60 is elevated in subjects with atherosclerosis in a general population. Circulation 2000; 102: 14-20
38. Keren P, George J, Shaish A, Levkovitz H, Janakovic Z, Afek A, Goldberg I, Kopolovic J, Keren G, Harats D. Effect of hyperglycemia and hyperlipidemia on atherosclerosis in LDL receptor-deficient mice. Establishment of a combined model and association with heat shock protein 65 immunity. Diabetes 2000; 49: 1064-1069