A convenient synthesis of novel 3-(heterocyclylsulfonyl)propanoic acids and their amide derivatives

Synthesis

Volumn , Issue 18, 2004, Pages 2999-3004

  Dorogov, Mikhail V ^a   Filimonov, Sergey I ^a   Kobylinsky, Dmitry B ^a   Ivanovsky, Sergey A ^a   Korikov, Pavel V ^a   Soloviev, Mikhail Y ^a   Khahina, Maria Y ^a   Shalygina, Elena E ^a   Kravchenko, Dmitry V ^a   Ivachtchenko, Alexandre V ^a  

^a CHEMDIV INC   (United States)

Author keywords

3 (heterocyclylsulfonyl)propanoic acid; Chlorosulfonates; Heterocycles; Libraries; Parallel synthesis

Indexed keywords

DERIVATIVES; REACTION KINETICS; SODIUM COMPOUNDS; SYNTHESIS (CHEMICAL);

CHLORINATING AGENTS; HETEROCYCLIC COMPOUNDS;

ORGANIC ACIDS;

1 ACETYL 5 [[3 [4 (2,5 DIMETHYLPHENYL)PIPERAZIN 1 YL] 3 OXOPROPYL]SULFONYL] 2 METHYLINDOLINE; 3 (2,1,3 BENZOTHIADIAZOL 4 YLSULFONYL) N CYCLOHEPTYLPROPANAMIDE; 3 (2,1,3 BENZOTHIADIAZOL 4 YLSULFONYL)PROPANOIC ACID; 3 (2,1,3 BENZOXADIAZOL 4 YLSULFONYL)PROPANOIC ACID; 3 (QUINOLIN 8 YLSULFONYL)PROPANOIC ACID; 3 [(1 ACETYL 2 METHYL 2,3 DIHYDRO 1H INDOL 5 YL)SULFONYL]PROPANOIC ACID; 3 [(1 ACETYL 2,3 DIHYDRO 1H INDOL 5 YL)SULFONYL] N [2 (3,4 DIETHOXYPHENYL)ETHYL]PROPANAMIDE; 3 [(1 ACETYL 2,3 DIHYDRO 1H INDOL 5 YL)SULFONYL]PROPANOIC ACID; 3 [(1 ACETYL 5 BROMO 2 METHYL 2,3 DIHYDRO 1H INDOL 7 YL)SULFONYL]PROPANOIC ACID; 3 [(1 ACETYL 5 BROMO 2,3 DIHYDRO 1H INDOL 7 YL)SULFONYL]PROPANOID ACID; 3 [(1,4 DIMETHYL 2,3 DIOXO 1,2,3,4 TETRAHYDROQUINOXALIN 6 YL)SULFONYL]PROPANOIC ACID; ACRYLIC ACID; AMIDE; ETHYL 4 [[3 [(1 ACETYL 5 BROMO 2 METHYL 2,3 DIHYDRO 1H INDOL 7 YL)SULFONYL]PROPANOYL]AMINO]PIPERIDINE 1 CARBOXYLATE; HETEROCYCLIC COMPOUND; N (1,3 BENZODIOXOL 5 YLMETHYL) 3 [(1,4 DIMETHYL 2,3 DIOXO 1,2,3,4 TETRAHYDROQUINOXALIN 6 YL)SULFONYL]PROPANAMIDE; N (3,4 DIMETHOXYPHENYL) 3 (QUINOLIN 8 YLSULFONYL)PROPANAMIDE; PROPIONIC ACID DERIVATIVE; SODIUM DERIVATIVE; SODIUM SULFINATE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL STRUCTURE; CHLORINATION; SULFONATION; SYNTHESIS;

EID: 19944393252     PISSN: 00397881     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2004-834888     Document Type: Article

References (9)

1. Munroe, J. E.; Shepherd, T. A.; Jungheim, L. N.; Hornback, W. J.; Hatch, S. D.; Muesing, M. A.; Wiskerchen, M.-A.; Su, K. S.; Campanale, K. M.; Baxter, A. J.; Colacino, J. M. Bioorg. Med. Chem. Lett. 1995, 5, 2897.
2. (a) Tucker, H.; Chesterson, G. J. J. Med. Chem. 1988, 31, 885.
3. (b) Baxter, A. D.; Bhogal, R.; Bird, J.; Keily, J. F.; Manallack, D. T.; Montana, J. G.; Owen, D. A.; Pitt, W. R.; Watson, R. J.; Wills, R. E. Bioorg. Med. Chem. Lett. 2001, 11, 1465.
4. Becker, D. P.; Barta, T. E.; Bedell, L.; DeCrescenzo, G.; Freskos, J.; Getman, D. P.; Hockerman, S. L.; Li, M.; Mehta, P.; Mischke, B.; Munie, G. E.; Swearingen, C.; Villamil, C. I. Bioorg. Med. Chem. Lett. 2001, 11, 2719.
5. Yamazaki, Y.; Akahane, M.; Kobayashi, M.; Kitazawa, M.; Kurashina, Y.; Iizuka, K. Jpn. J. Pharmacol. 1993, 63, 219; Chem. Abstr., 1994, 120, 23328.
6. Yamazaki, Y.; Akahane, M.; Kobayashi, M.; Kitazawa, M.; Kurashina, Y.; Iizuka, K. Jpn. J. Pharmacol. 1993, 63, 219; Chem. Abstr., 1994, 120, 23328.
7. Tyuneva, I. V.; Filimonov, S. I.; Soloviev, M. Y.; Balakin, K. V.; Skorenko, A. V.; Dorogov, M. V. Proc. Inst. Higher Edu.: Chem. Techn. (Russia) 2003, 46, 77; Chem. Abstr. 2004, 747, 54130.
8. Tyuneva, I. V.; Filimonov, S. I.; Soloviev, M. Y.; Balakin, K. V.; Skorenko, A. V.; Dorogov, M. V. Proc. Inst. Higher Edu.: Chem. Techn. (Russia) 2003, 46, 77; Chem. Abstr. 2004, 747, 54130.
9. Baru, M.; Ivachtchenko, A. Russian Patent 2180609, 2002; Chem. Abstr. 2003, 138, 14907.