Antiphospholipid antibodies are induced by in vitro fertilization and correlate with paraoxonase activity and total antioxidant capacity of plasma in infertile women

Lupus

Volumn 14, Issue 5, 2005, Pages 373-380

  Delgado Alves, José ^a,e   Radway Bright, E L ^a   Lee, S ^b   Grima, B ^c   Hothersall, J ^d   Ravirajan, C T ^a   Isenberg, D A ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b Portland Hospital   (United Kingdom)

^c HOSPITAL CURRY CABRAL   (Portugal)

^d INSTITUTE OF UROLOGY AND NEPHROLOGY   (United Kingdom)

^e NOVA MEDICAL SCHOOL   (Portugal)

Author keywords

Antiphospholipid antibodies; Infertility; IVF treatment; Paraoxonase; Total anti oxidant capacity

Indexed keywords

ANTIBODY; ARYLDIALKYLPHOSPHATASE; CARDIOLIPIN ANTIBODY; PHOSPHATIDYLSERINE ANTIBODY; PHOSPHOLIPID ANTIBODY; UNCLASSIFIED DRUG;

ANTIBODY TITER; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE ASSOCIATION; ENZYME ACTIVITY; FEMALE; FEMALE INFERTILITY; FERTILIZATION IN VITRO; HUMAN; MAJOR CLINICAL STUDY; OXIDATION; PRIORITY JOURNAL; SERUM;

ANTIBODIES, ANTICARDIOLIPIN; ANTIBODIES, ANTIPHOSPHOLIPID; ANTIOXIDANTS; ARYLDIALKYLPHOSPHATASE; AUTOANTIBODIES; CASE-CONTROL STUDIES; FEMALE; FERTILIZATION IN VITRO; HUMANS; INFERTILITY, FEMALE; PHOSPHATIDYLSERINES; REGRESSION ANALYSIS;

EID: 19944388569     PISSN: 09612033     EISSN: None     Source Type: Journal    
DOI: 10.1191/0961203305lu2096oa     Document Type: Article

References (31)

1. Harris EN, Gharavi AE. Boey ML et al. Anticardiolipin antibodies: detection by radioimmunoassay and association with thrombosis in systemic lupus erythematosus. Lancet 1983; 2: 1211-1214.
2. Morrow J, Nelson L, Watts R, Isenberg DA. Primary anti-phospholipid antibody syndrome. In Autoimmune rheumatic diseases, 2nd edition. Oxford: Oxford University Press, 1999: 216-232.
3. Van Voorhis BJ, Stovall DW. Autoantibodies and infertility: a review of the literature. J Reprod Immunol 1997; 33: 239-256.
4. Nip MM, Taylor PV, Rutherford AJ, Hancock KW. Autoantibodies and antisperm antibodies in sera and follicular fluids of infertile patients: relation to reproductive outcome after in-vitro fertilization. Hum Reprod 1995; 10: 2564-2569.
5. Sher G, Feinman M, Zouves C et al. High fecundity rates following in-vitro fertilization and embryo transfer in antiphospholipid antibody seropositive women treated with heparin and aspirin. Hum Reprod 1994; 9: 2278-2283.
6. Kutteh WH. Antiphospholipid antibodies and reproduction. J Reprod Immunol 1997; 35: 151-171.
7. Azem F, Geva E, Amit A et al. High levels of anticardiolipin antibodies in patients with abnormal embryo morphology who attended an in vitro fertilization program. Am J Reprod Immunol 1998; 39: 161-163.
8. Aoki K, Dudkiewicz AB, Matsuura E, Novotny M, Kaberlein G, Gleicher N. Clinical significance of beta 2-glycoprotein I-dependent anticardiolipin antibodies in the reproductive autoimmune failure syndrome: correlation with conventional antiphospholipid antibody detection systems. Am J Obstet Gynecol 1995; 172: 926-931.
9. Fisch B, Fried S, Manor Y, Ovadia J, Witz IP, Yron I. Increased antiphospholipid antibody activity in in-vitro fertilization patients is not treatment-dependent but rather an inherent characteristic of the infertile state. Am J Reprod Immunol 1995; 34: 370-374.
10. Wilson WA, Gharavi AE, Koike T et al. International consensus statement on preliminary classification criteria for definite antiphospholipid syndrome: report of an international workshop. Arthritis Rheum 1999; 42: 1309-1131.
11. Birdsall MA, Lockwood GM, Ledger WL, Johnson PM, Chamley LW Antiphospholipid antibodies in women having in-vitro fertilization. Hum Reprod 1996; 11: 1185-1189.
12. Geva E, Amit A, Lerner-Geva L, Azem F, Yovel I, Lessing JB. Autoimmune disorders: another possible cause for in-vitro fertilization and embryo transfer failure. Hum Reprod 1995; 10: 2560-2563.
13. Ames PR, Tommasino C, Alves J et al. Antioxidant susceptibility of pathogenic pathways in subjects with antiphospholipid antibodies: a pilot study. Lupus 2000; 9: 688-695.
14. Reubinoff BE, Har-El R, Kitrossky N et al. Increased levels of redoxactive iron in follicular fluid: a possible cause of free radical-mediated infertility in beta-thalassemia major. Am J Obstet Gynecol 1996; 174: 914-918.
15. Ivaniota L, Dubchak AS, Tyshchenko VK. Free radical oxidation of lipids and antioxidant system of blood in infertile women in a radioactive environment. Ukr Biokhim Zh 1998; 70: 132-135.
16. Nonogaki T, Noda Y, Narimoto K, Umaoka Y, Mori T. Protection from oxidative stress by thioredoxin and superoxide dismutase of mouse embryos fertilized in vitro. Hum Reprod 1991; 6: 1305-1310.
17. Ames PR, Nourooz-Zadeh J, Tommasino C, Alves J, Brancaccio V, Anggard EE. Oxidative stress in primary antiphospholipid syndrome. Thromb Haemost 1998; 79: 447-449.
18. Morrow JD, Roberts LJ. The isoprostanes. Current knowledge and directions for future research. Biochem Pharmacol 1996; 51: 1-9.
19. Landino LM, Crews BC, Timmons MD, Morrow JD, Marnett LJ, Peroxynitrite, the coupling product of nitric oxide and superoxide, activates prostaglandin biosynthesis. Proc Natl Acad Sci USA 1996; 93: 15069-15074.
20. Mackness MI, Arrol S, Durrington PN. Paraoxonase prevents accumulation of lipoperoxides in low-density lipoprotein. FEBS Lett 1991; 286: 152-154.
21. Lambert M, Boullier A, Hachulla E et al. Paraoxonase activity is dramatically decreased in patients positive for anticardiolipin antibodies. Lupus 2000; 9: 299-300.
22. Delgado Alves J, Ames PRJ, Donohue S et al. Paraoxonase activity correlates with anticardiolipin antibodies in APS. Lupus 2001; 10 (suppl. 1), S9.
23. Eckerson HW, Wyte CM, La Du BN. The human serum paraoxonase/arylesterase polymorphism. Am J Hum Genet 1983; 35: 1126-1138.
24. Delgado Alves J, Ames PRJ, Donohue S et al. Antibodies towards high density lipoprotein and beta-2-glycoprotein-I are inversely correlated with paraoxonase activity in systemic lupus erythematosus (SLE) and primary antiphospholipid syndrome (PAPS). Arthritis Rheum 2002; 46: 2686-2694.
25. Fisch B, Rikover Y, Shohat L et al. The relationship between in vitro fertilization and naturally occurring antibodies: evidence for increased production of antiphospholipid autoantibodies. Fertil Steril 1991; 56: 718-724.
26. Ware BD, Hatasaka HH. Antiphospholipid antibodies and infertility: fact or fallacy. Lupus 1998; 7 (suppl. 2): S90-S94.
27. Yron I, Tadir Y, Ovadia J et at. Evidence for increased levels of circulating antiphospholipid autoantibodies in patients undergoing in vitro fertilization treatment. Ann NY Acad Sci 1992; 651: 599-601.
28. Chilcott IT, Margara R, Cohen H et al. Pregnancy outcome is not affected by antiphospholipid antibody status in women referred for in vitro fertilization. Fertil Steril 2000; 73: 526-530.
29. Carr AC, McCall MR, Frei B. Oxidation of LDL by myeloperoxidase and reactive nitrogen species: reaction pathways and antioxidant protection. Arterioscler Thromb Vasc Biol 2000; 20: 1716-1723.
30. Zhu X, Bonet B, Gillenwater H, Knopp RH. Opposing effects of estrogen and progestins on LDL oxidation and vascular wall cytotoxicity: implications for atherogenesis. Proc Soc Exp Biol Med 1999; 222: 214-221.
31. Santanam N, Shern-Brewer R, McClatchey R et al. Estradiol as an antioxidant: incompatible with its physiological concentrations and function. J Lipid Res 1998; 39: 2111-2118.