Severe community-acquired pneumonia: Determinants of severity and approach to therapy

Infections in Medicine

Volumn 22, Issue 2, 2005, Pages 53-58

  Cunha, Burke A ^a,b  

^a WINTHROP UNIVERSITY HOSPITAL   (United States)

^b STONY BROOK UNIVERSITY   (United States)

Author keywords

Antibiotic therapy, outpatient; Immune function; Pneumonia, community acquired

Indexed keywords

AMPICILLIN; ANTIINFECTIVE AGENT; BETA LACTAM ANTIBIOTIC; CEFTIZOXIME; CEFTRIAXONE; DOXYCYCLINE; GATIFLOXACIN; LEVOFLOXACIN; MACROLIDE; MOXIFLOXACIN; PENICILLIN G; QUINOLONE DERIVATIVE; TETRACYCLINE;

AGING; ARTICLE; BACTEREMIA; BACTERIAL STRAIN; BACTERIAL VIRULENCE; CATHETER INFECTION; CELLULAR IMMUNITY; COMMUNITY ACQUIRED PNEUMONIA; CONGESTIVE HEART FAILURE; COST EFFECTIVENESS ANALYSIS; DEFENSE MECHANISM; DISEASE SEVERITY; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG ELIMINATION; DRUG FEVER; EMPYEMA; HAEMOPHILUS INFLUENZAE; HEART FAILURE; HEART FUNCTION; HOST RESISTANCE; HUMAN; HUMORAL IMMUNITY; KIDNEY DYSFUNCTION; LEGIONELLA; LIVER DISEASE; LUNG FUNCTION; MONOTHERAPY; MORAXELLA CATARRHALIS; PENICILLIN RESISTANCE; STREPTOCOCCUS PNEUMONIAE; SURGICAL DRAINAGE; THORAX RADIOGRAPHY; THROMBOEMBOLISM; TREATMENT FAILURE; URINARY EXCRETION; URINARY TRACT INFECTION;

EID: 19944379861     PISSN: 07496524     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Marrie TJ, Durant H, Yates L. Community-acquired pneumonia requiring hospitalization: 5-year prospective study. Rev Infect Dis. 1989;11: 586-599.
2. Angus DC, Marrie TJ, Obrosky DS, et al. Severe community-acquired pneumonia: use of intensive care services and evaluation of American and British Thoracic Society diagnostic criteria. Am J Respir Crit Care Med. 2002;166:717-723.
3. Lim WS, van der Eerden MM, Laing R, et al. Defining community acquired pneumonia severity on presentation to hospital: an international derivation and validation study. Thorax. 2003;58:377-382.
4. El-Solh AA, Sikka P, Ramadan F, Davies J. Etiology of severe pneumonia in the very elderly. Am J Respir Crit Care Med. 2001;163(3 pt 1):645-651.
5. Cunha BA. Community-acquired pneumonia. In: Cunha BA, ed. EMedicine: Infectious Diseases.com (internet medical textbook) 2001. Available at: http://www.emedicine.com/med/topic3162.htm. Accessed January 5, 2005.
6. MacFarlane JT, Finch RG, Ward MJ, Macrae AD. Hospital study of adult community-acquired pneumonia. Lancet. 1982;2:255-258.
7. Moine P, Vercken JB, Chevret S, et al. Severe community-acquired pneumonia. Etiology, epidemiology, and prognosis factors. French Study Group for Community-Acquired Pneumonia in the Intensive Care Unit. Chest. 1994; 105:1487-1495.
8. Klimek JJ, Ajemian E, Fontecchio S, et al. Community-acquired bacterial pneumonia requiring admission to hospital. Am J Infect Control. 1983;11:79-82.
9. Cunha BA. Community-acquired pneumonia: reality revisited. Am J Med. 2000;108:436-438.
10. Cunha BA. Community-acquired pneumonia: 20 clinical pearls. Infect Med. 2003;20:27-30.
11. Farr BM, Sloman AJ, Fisch MJ. Predicting death in patients hospitalized for community-acquired pneumonia. Ann Intern Med. 1991;115: 428-436.
12. Janssens JP, Gauthey L, Herrmann F, et al. Community-acquired pneumonia in older patients. J Am Geriatr Soc. 1996;44:539-544.
13. Leroy O, Santré C, Beuscart C, et al. A five-year study of severe community-acquired pneumonia with emphasis on prognosis in patients admitted to an intensive care unit. Intensive Care Med. 1995;21:24-31.
14. van Riemsdijk-van Overbeeke IC, van den Berg B. Severe Legionnaire's disease requiring intensive care treatment. Neth J Med. 1996;49:196-201.
15. Cunha BA. Strategies for managing severe community-acquired pneumonia. J Crit Illness. 1997;12:711-721.
16. Cunha BA. Severe community-acquired pneumonia. In: Cunha BA, ed. Infectious Diseases in Critical Care Medicine. New York Marcel Dekker; 1998:233-246.
17. Cunha BA. Infections in nonleukopenic compromised hosts (diabetes mellitus, SLE, steroids, and asplenia) in critical care. Crit Care Clin. 1998;14:263-282.
18. Cunha BA. Differentiating pneumonitis and pneumonia in your SLE patient. J Crit Illness 1997;12:779-783.
19. Gopal V, Bisno AL. Fulminant pneumococcal infections in "normal" asplenic hosts. Arch Intern Med. 1977; 137:1526-1530.
20. Jong GM, Hsiue TR, Chen CR, et al. Rapidly fatal outcome of bacteremic Klebsiella pneumoniae pneumonia in alcoholics. Chest. 1995;107: 214-217.
21. Wara DW. Host defense against Streptococcus pneumoniae: the role of the spleen. Rev Infect Dis. 1981;3:299-309.
22. Cunha BA. Pneumonias in the compromised host. Infect Dis Clin North Am. 2001;15:591-612.
23. Cunha BA. Community-acquired pneumonia in human immunodeficiency virus-infected patients. Clin Infect Dis. 1999;28:410-411.
24. Minnaganti V, Cunha BA. Infections associated with uremia and dialysis. Infect Dis Clin North Am. 2001;15:385-406, viii.
25. Johnson DH, Cunha BA. Infections in cirrhosis. Infect Dis Clin North Am. 2001;15:363-371, vii.
26. Cunha BA. Empiric therapy of community-acquired pneumonia: guidelines for the perplexed? Chest. 2004;125:1913-1919.
27. Cunha BA. Community-acquired pneumonia. Diagnostic and therapeutic approach. Med Clin North Am. 2001;85:43-77.
28. Cunha BA. Severe community-acquired pneumonia. Crit Care Clin. 1998;14:105-118.
29. Fine MJ, Stone RA, Lave JR, et al. Implementation of an evidence-based guideline to reduce duration of intravenous antibiotic therapy and length of stay for patients hospitalized with community-acquired pneumonia: a randomized controlled trial. Am J Med. 2003;115:343-351.
30. Cunha BA. Antibiotic treatment of severe community-acquired pneumonia. Semin Respir Crit Care Med. 2000;21:61-69.
31. Dean NC, Silver MP, Bateman KA, et al. Decreased mortality after implementation of a treatment guideline for community-acquired pneumonia. Am J Med. 2001;110:451-457.
32. Heath CH, Grove DI, Looke DF. Delay in appropriate therapy of Legionella pneumonia associated with increased mortality. Eur J Clin Microbiol Infect Dis. 1996;15:286-290.
33. Cunha BA. Strategies to control antibiotic resistance. Semin Respir Crit Care Med. 2000;21: 3-8.
34. Cunha BA. Antibiotic resistance. Control strategies. Crit Care Clin. 1998;14:309-327.
35. Cunha BA. Effective antibiotic-resistance control strategies. Lancet. 2001;357:1307-1308.
36. Cunha BA. Clinical relevance of penicillin-resistant Streptococcus pneumoniae. Semin Respir Infect. 2002;17:204-214.
37. Cunha BA. Infections and asplenia. Infect Dis Pract. 1997;21:48-49.