Splanchnic hypoperfusion-directed therapies in trauma: A prospective, randomized trial

American Surgeon

Volumn 71, Issue 3, 2005, Pages 252-260

  Cohn, Stephen M ^a  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; ADRENALIN; ALPHA TOCOPHEROL; ASCORBIC ACID; DOBUTAMINE; DOPAMINE; GLUTAMINE; GLYCERYL TRINITRATE; ISOPRENALINE; MANNITOL; NITROPRUSSIDE SODIUM; NORADRENALIN; POLYMYXIN; PROSTACYCLIN; SELENIUM;

ADULT; AGED; ARTICLE; CLINICAL TRIAL; COLLOID; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CRYSTALLOID; FEMALE; FLUID RESUSCITATION; HEMODYNAMIC MONITORING; HUMAN; HUMAN TISSUE; INJURY; INJURY SEVERITY; INOTROPISM; INTENSIVE CARE UNIT; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; MORTALITY; PERFUSION; RANDOMIZED CONTROLLED TRIAL; SPLANCHNIC BLOOD FLOW; STOMACH PH; TONOMETRY; APACHE; COMPARATIVE STUDY; EMERGENCY HEALTH SERVICE; FLUID THERAPY; HEMODYNAMICS; INJURY SCALE; INTENSIVE CARE; MANOMETRY; METHODOLOGY; MIDDLE AGED; MULTIPLE ORGAN FAILURE; MULTIPLE TRAUMA; PH; PHYSIOLOGY; PROBABILITY; PROGNOSIS; PROSPECTIVE STUDY; REFERENCE VALUE; RESUSCITATION; RISK ASSESSMENT; SENSITIVITY AND SPECIFICITY; SHOCK; SURVIVAL RATE; TREATMENT OUTCOME;

AGED; APACHE; FEMALE; FLUID THERAPY; GASTRIC ACIDITY DETERMINATION; HEMODYNAMIC PROCESSES; HUMANS; HYDROGEN-ION CONCENTRATION; INJURY SEVERITY SCORE; INTENSIVE CARE; MALE; MANOMETRY; MIDDLE AGED; MULTIPLE ORGAN FAILURE; MULTIPLE TRAUMA; PERFUSION; PROBABILITY; PROGNOSIS; PROSPECTIVE STUDIES; REFERENCE VALUES; RESUSCITATION; RISK ASSESSMENT; SENSITIVITY AND SPECIFICITY; SHOCK; SPLANCHNIC CIRCULATION; SURVIVAL RATE; TRAUMA CENTERS; TREATMENT OUTCOME;

EID: 19844370391     PISSN: 00031348     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Fiddian-Green RG, Pittenger G, Whitehouse WM Jr. Back-diffusion of CO2 and its influence on the intramural pH in gastric mucosa. J Surg Roes 1982;33:39-48.
2. Bass BL, Schweitzer EJ, Harmon JW, et al. Intraluminal PCO2: A reliable indicator of intestinal ischemia. J Surg Roes 1985;39:351-60.
3. Maynard N, Bihari D, Beale R, et al. Assessment of splanchnic oxygenation by gastric tonometry in patients with acute circulatory failure. JAMA 1993;270:1203-10.
4. Roumen RM, Vreugde JP, Goris RJ. Gastric tonometry in multiple trauma patients. J Trauma 1994;36:313-6.
5. Doglio GR, Pusajo JF, Egurrola MA, et al. Gastric mucosal pH as a prognostic index of mortality in critically ill patients. Crit Care Med 1994;19:1037-40.
6. Chang MC, Cheatham ML, Nelson LD, et al. Gastric tonometry supplements information provided by systemic indicators of oxygen transport. J Trauma 1998;45:868-72.
7. Ivatury RR, Simon RJ, Islam S, et al. A prospective randomized study of end points of resuscitation after major trauma: Global oxygen transport indices versus organ-specific gastric mucosal pH. J Am Coll Surg 1996;183:145-54.
8. Gutierrez G, Palizas F, Doglio G, et al. Gastric intramucosal pH as a therapeutic index of tissue oxygenation in critically ill patients. Lancet 1992;339:195-9.
9. Barquist E, Kirton O, Windsor J, et al. The impact of antioxidant and splanchnic-directed therapy on persistent uncorrected gastric mucosal pH in the critically injured trauma patient. J Trauma 1998;44:355-60.
10. Nathens A, Neff M, Jurkovich G, et al. Randomized, prospective trial of antioxidant supplementation in critically ill surgical patients. Ann Surg 2002;236:814-22.
11. Bishop M, Shoemaker W, Appel P, et al. Prospective randomized trial of survivor values of cardiac index, oxygen delivery, and oxygen consumption as resuscitation endpoints in severe trauma. J Trauma 1995;38:780-7.
12. Velmahos GC, Demetriades D, Shoemaker W, et al. End-points of resuscitation of critically injured patients: Normal or supranormal. Ann Surg 2000;232:409-18.
13. McKinley B, Kozar R, Cocanour C, et al. Normal versus supranormal oxygen delivery goals in shock resuscitation: The response is the same. J Trauma 2002;53:825-32.
14. Rivers E, Nguyen B, Havstad S, et al. Early goal-detected therapy in the treatment of severe sepsis and septic shock. N Engl J Med 2001;345:1368-77.
15. Porter J, Ivatury R. In search of the optimal end points of resuscitation in trauma patients: A review. J Trauma 1998;44: 908-14.
16. Silva E, DeBacker D, Creteur J, et al. Effects of vasoactive drugs on gastric intramucosal pH. Crit Care Med 1996;26: 1749-58.
17. Sautner T, Wessely C, Riegler M, et al. Early effects of catecholamine therapy on mucosal integrity, intestinal blood flow, and oxygen metabolism in porcine endotoxin shock. Ann Surg 1998;228:239-48.
18. Meier-Hellmann A, Reinhart K, Bredle DL, et al. Epinephrine impairs splanchnic perfusion in septic shock. Crit Care Med 1997;25:399-404.
19. Andrews FJ, Malcontenti-Wilson C, O'Brien PE. Protection against gastric ischemia-reperfusion injury in nitric oxide generators. Dig Dis Sci 1994;39:366-73.
20. King R, Binns OAR, Chai Kanithanon R, et al. Low-dose sodium nitroprusside reduces pulmonary reperfusion injury. Ann Thorac Surg 1997;63:1398-404.
21. Chang P, Rutlen D. Effects of β-adrenergic agonists on splanchnic vascular volume and cardiac output. Am J Physiol 1991;261:H1499-507.
22. Parks D, Granger DN. Ischemia-induced vascular changes: Role of xanthine oxidase and hydroxyl radicals. Am J Physiol 1983;245:G285-9.
23. Porter JM, Ivatury RR, Azimuddin K, Swami R. Antioxidant therapy in the prevention of organ dysfunction syndrome and infectious complications after trauma: Early results of a prospective randomized study. Am Surg 1999;65:478-83.
24. Martinez-Pellus AE, Merino P, Bru M, et al. Endogenous endotoxins of intestinal origin during cardiopulmonary bypass. Intensive Care Med 1997;23:1251-7.
25. Fink MP. Gastrointestinal mucosal injury in experimental models of shock, trauma and sepsis. Crit Care Med 1991;19: 627-41.
26. Ely EW, Bernard G. Transfusion in critically ill patients. N Engl J Med 1999;340:467-8.
27. Gomersall CD, Joynt GM, Freebairn RC, et al. Resuscitation of critically ill patients based on the results of gastric tonometry: A prospective, randomized, controlled trial. Crit Care Med 2000;28:607-14.
28. Agusti M, Elizalde JI, Adalàlia R, et al. Dobutamine restores intestinal mucosal blood flow in a porcine model of intra-abdominal hyperpressure. Crit Care Med 2000;28:467-72.
29. Heino A, Kartikainen J, Merasto M, et al. Effects of dobutamine on splanchnic tissue perfusion during partial superior mesenteric artery occlusion. Crit Care Med 2000;28:3483-90.
30. Manasia A, Kang H, Hannon E, et al. Effects of the stable prostacyclin analogue iloprost on mesenteric blood flow in porcine endotoxic shock. Crit Care Med 1997;25:1222-7.
31. Weinbroum AA, Hochhauser E, Rudick V, et al. Multiple organ dysfunction after remote circulatory arrest: Common pathway of radical oxygen species? J Trauma 1999;47:691-8.
32. Günel E, Çaǧlayan F, Çaǧlayan O, et al. Treatment of intestinal reperfusion injury using antioxidant agents. J Pediatr Surg 1998;33:1536-9.
33. Holben DH, Smith AM. The diverse role of selenium within selenoproteins: A review. Am Diet Assoc. 1999;99:836-43.
34. Tanaka H, Matsuda T, Miyagantani Y, et al. Reduction of resuscitation fluid volumes in severely burned patients using ascorbic acid administration. Arch Surg 2000;135:326-31.