Facial skin rejuvenation with a novel topical compound containing transforming growth factor β1 and vitamin C

Cosmetic Dermatology

Volumn 17, Issue 11, 2004, Pages

  Rao, Jaggi ^a   Ehrlich, Michelle ^b   Goldman, Mitchel P ^a,c  

^a Dermatology/Cosmetic Laser Associates   (United States)

^b LERNER RESEARCH INSTITUTE   (United States)

^c Topix Pharmaceutical Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASCORBIC ACID; CIMICIFUGA RACEMOSA EXTRACT; TRANSFORMING GROWTH FACTOR BETA1;

ADULT; ARTICLE; CREAM; DRUG EFFICACY; DRUG TOLERANCE; FEMALE; HISTOPATHOLOGY; HUMAN; NORMAL HUMAN; PATIENT SATISFACTION; PHOTOGRAPHY; QUESTIONNAIRE; REJUVENATION; SKIN BIOPSY; SKIN DISEASE; SUN EXPOSURE; WRINKLE;

EID: 19744382300     PISSN: 10413766     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Chung JH, Hanft VN, Kang S. Aging and photoaging. J Am Acad Dermatol. 2003;49:690-697.
2. Pinnell SR. Cutaneous photodamage, oxidative stress, and topical antioxidant protection. J Am Acad Dermatol. 2003;48:1-19.
3. Trautinger F. Mechanisms of photodamage of the skin and its functional consequences for skin ageing. Clin Exp Dermatol. 2001;26:573-577.
4. Yaar M, Gilchrest BA. Skin aging: postulated mechanisms and consequent changes in structure and function. Clin Geriatr Med. 2001;17:617-630.
5. Sadick NS. A structural approach to nonablative rejuvenation. Cosmet Dermatol. Dec 2002;15:39-43.
6. Sadick NS. Cosmeceuticals: their role in dermatology practice. J Drugs Dermatol. 2003;2:529-537.
7. Kligman AM. Why cosmeceuticals? Cosmet Toiletries. 1993;108:37-38.
8. Fitzpatrick RE, Rostan EF. Reversal of photodamage with topical growth factors: a pilot study. J Cosmet Laser Ther. 2003;5:25-34.
9. Vermeer BJ, Gilchrest BA. Cosmeceuticals: a proposal for rational definition, evaluation, and regulation. Arch Dermatol. 1996;132:337-340.
10. Fisher GJ, Kang S, Varani J, et al. Mechanisms of photoaging and chronological skin aging. Arch Dermatol. 2002;138:1462-1470.
11. Shindo Y, Witt E, Han D, et al. Enzymatic and non-enzymatic antioxidants in epidermis and dermis of human skin. J Invest Dermatol. 1994;102:122-124.
12. Fisher GJ, Voorhees JJ. Molecular mechanisms of photoaging and its prevention of retinoic acid: ultraviolet irradiation induces MAP kinase signal transduction cascades that induce AP-1-regulated matrix metalloproteinases that degrade human skin in vitro. J Investig Dermatol Symp Proc. 1998;3:61-68.
13. Varani J, Spearman D, Perone P, et al. Inhibition of type I procollagen synthesis by damaged collagen in photoaged skin and by collagenase-degraded collagen in vitro. Am J Pathol. 2001;158:931-942.
14. Griffiths CE, Russman AN, Majmudar G, et al. Restoration of collagen formation in photodamaged human skin by tretinoin (retinoic acid). N Engl J Med. 1993;329:530-535.
15. Wlaschek M, Tantcheva-Poor I, Naderi L, et al. Solar UV irradiation and dermal photoaging. J Photochem Photobiol B. 2001;63:41-51.
16. Rothe M, Falanga V. Growth factors: their biology and promise in dermatologie diseases and tissue repair. Arch Dermatol. 1989;125:1390-1398.
17. Tjaderhane L, Palosaari H, Wahlgren J, et al. Human odontoblast culture method: the expression of collagen and matrix metalloproteinases (MMPs). Adv Dent Res. 2001;15:55-58.
18. Cutroneo KR. Gene therapy for tissue regeneration. J Cell Biochem. 2003;88:418-425.
19. Govinden R, Bhoola KD. Genealogy, expression, and cellular function of transforming growth factor-beta. Pharmacol Ther. 2003;98:257-265.
20. Rumsey SC, Wang Y, Levine M. Vitamin C. In: Papas AM, ed. Antioxidant Status, Diet, Nutrition, and Health. Boca Raton, Fla: CRC Press; 1999:159-188.
21. Colven RM, Pinnell SR. Topical vitamin C in aging. Clin Dermatol. 1996;14:227-234.
22. Darr D, Dunston S, Faust H, et al. Effectiveness of antioxidants (vitamin C and E) with and without sunscreens as topical photo-protectants. Acta Derm Venereol. 1996;76:264-268.
23. Davidson JM, Luvalle PA, Zoia O, et al. Ascorbate differentially regulates elastin and collagen biosynthesis in vascular smooth muscle cells and skin fibroblasts by pretranslational mechanisms. J Biol Chem. 1997;272:345-52.
24. Maeda K, Fukuda M. Arbutin: mechanism of its depigmenting action in human melanocyte culture. J Pharmacol Exp Ther. 1996;276:765-769.
25. Tajima S, Pinnell SR. Ascorbic acid preferentially enhances type I and III collagen gene transcription in human skin fibroblasts. J Dermatol Sci. 1996;11:250-253.
26. Uchida Y Behne M, Quiec D, et al. Vitamin C stimulates sphingolipid production and markers of barrier formation in submerged human keratinocyte cultures. J Invest Dermatol. 2001;117:1307-1313.
27. Duke JA. Handbook of Phytochemical Constituents of Grass Herbs and Other Economic Plants. Boca Raton, Fla: CRC Press: 1992.
28. Seidlova-Wuttke D, Hesse O, Jarry H, et al. Evidence for selective estrogen receptor modulator activity in a black cohosh (Cimicifuga racemose) extract: comparison with estradiol-17beta. Eur J Endocrinol. 2003;149:351-362.
29. Zierau O, Bodinet C, Kolba S, et al. Antiestrogenic activities of Cimicifuga racemose extracts. J Steroid Biochem Mol Biol. 2002;80:125-130.
30. Duffy DM. Silicone: a critical review. Adv Dermatol. 1990;5:93-107; discussion 108-109.
31. Naoum C, Dasiou-Plakida D, Pantelidaki K, et al. A histological and immunohistochemical study of medical-grade fluid silicons. Dermatol Surg. 1998;24:867-870.
32. Nair B; Cosmetic Ingredients Review Expert Panel: Final report on the safety assessment of stearoxy dimethicone, dimethicone, methicone, amino bispropyl dimethicone, aminopropyl dimethicone, amodimethicone, amodimethicone hydroxystearate, behenoxy dimethicone, C24-28 alkyl methicone, C30-45 alkyl methicone, C30-45 alkyl dimethicone, cetearyl methicone, cetyl dimethicone, dimethoxysilyl ethylenediaminopropyl dimethicone, hexyl methicone, hydroxypropyldimethicone, stearamidopropyl dimethicone, stearyl dimethicone, stearyl methicone, and vinyldimethicone. Int J Toxicol. 2003;22(suppl 2):11-35.
33. Perkins K, Davey RB, Wallis KA. Silicone gel: a new treatment for burn scars and contractures. Burns Incl Therm Inj. 1983;9:201-204.
34. Quinn KJ. Silicone gel in scar treatment. Burns Incl Therm Inj. 1987;13(suppl):S33-S40.
35. Katz BE. Silastic gel sheeting is found to be effective in scar therapy. Cosmet Dermatol. June 1992;5:32-34.
36. Balkin SW. Treatment of painful scars on soles and digits with injections of fluid silicone. J Dermatol Surg Oncol. 1977;3:612-614.
37. Balkin SW. The fluid silicone prosthesis. Clin Podiatry. 1984;1:145-164.
38. Ahn ST, Monafo WW, Mustoe TA. Topical silicone gel for the prevention and treatment of hypertrophic scar. Arch Surg. 1991;126:499-504.
39. Eishi K, Bae SJ, Ogawa F, et al. Silicone gel sheets relieve pain and pruritus with clinical improvement of keloid: possible target of mast cells. J Dermatol Treat. 2003;14:248-252.
40. Kuhn MA, Moffit MR, Smith PD, et al. Silicone sheeting decreases fibroblast activity and downregulates TGFbeta2 in hypertrophic scar model. Int J Surg Investig. 2001;2:467-474.