The stress axis gone awry: A possible neuroendocrine explanation for increased risk of completed suicide

Primary Psychiatry

Volumn 12, Issue 5, 2005, Pages 49-52

  Bostwick, John Michael ^a,b  

^a Mayo Clinic   (United States)

^b MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOSTEROID; DEXAMETHASONE; HYDROCORTISONE;

AGITATION; ANXIETY DISORDER; BRAIN DYSFUNCTION; DEPRESSION; DEPRESSIVE PSYCHOSIS; DEXAMETHASONE SUPPRESSION TEST; DIAGNOSTIC ACCURACY; HOMEOSTASIS; HUMAN; HYPERACTIVITY; HYPERCORTISOLISM; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; MELANCHOLIA; MENTAL HEALTH; NEUROENDOCRINOLOGY; REVIEW; RISK FACTOR; STRESS; SUICIDE; SURVIVAL;

EID: 19644378056     PISSN: 10826319     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (31)

1. Arana GW, Baldessarini RJ, Ornsteen M. The dexamethasone suppression test for diagnosis and prognosis in psychiatry. Commentary and review. Arch Gen Psychiatry. 1985;42(12):1193-1204.
2. Kino T, Chrousos GP. Glucocorticoid and mineralocorticoid resistance/hypersensitivity syndromes. J Endocrinol. 2001;169(3):437-445.
3. Cannon WB. The Wisdom of the Body. New York, NY: W.W. Norton; 1939.
4. Cushing H. Psychic disturbance associated with disorders of the ductless glands. Am J Insanity. 1913;69(5):965-990.
5. Varghese FP, Brown ES. The Hypothalamic-pituitary-adrenal axis in major depressive disorder: a brief primer for primary care physicians. Prim Care Companion J Clin Psychiatry. 2001;3(4):151-155.
6. Sachar EJ. Corticosteroids in depressive illness. II. A longitudinal psychoendocrine study. Arch Gen Psychiatry. 1967;17(5):554-567.
7. Sachar EJ, Hellman L, Fukushima DK, Gallagher TF. Cortisol production in depressive illness. A clinical and biochemical clarification. Arch. Gen Psychiatry. 1970;23(4):289-298.
8. Bunney WE, Mason JW, Roatch JF, Hamburg DA. A psychoendocrine study of severe psychotic depressive crises. Am J Psychiatry. 1965;122(1):72-80.
9. Gibbons JL. The secretion rate of corticosterone in depressive illness. J Psychosom Res. 1967;10:263-266.
10. Butler PW, Besser GM. Pituitary-adrenal function in severe depressive illness. Lancet. 1968;1(7554):1234-1236.
11. Carroll BJ, Feinberg M, Greden JE et al. A specific laboratory test for the diagnosis of melancholia. Standardization, validation, and clinical utility. Arch Gen Psychiatry. 1981;38(1):15-22.
12. Zimmerman M, Coryell W, Pfohl B. The validity of the dexamethasone suppression test as a marker for endogenous depression. Arch Gen Psychiatry. 1986;43(4):347-355.
13. Ros CA. Biological tests for mental illness: their use and misuse, Biol Psychiatry. 1986;21(5-6):431-435.
14. The APA Task Force on Laboratory Tests in Psychiatry. The dexamethasone suppression test: an overview of its current status in psychiatry. Am J Psychiatry. 1987;144(10):1253-1262.
15. Coryell W, Schiesser M. The dexamethasone suppression test and suicide prediction, Am J Psychiatry. 2001;158(5):748-753.
16. Bostwick JM, Warzecha J. The dexamethasone suppression test as a predictor of suicide risk. Mayo Clin Proc. In press.
17. Mackin P, Young AH. The role of cortisol and depression: exploring new opportunities for treatment. Psychiatric Times. 2004;21(6):92-95.
18. Reus VI. Pituitary-adrenal disinhibition as the independent variable in the assessment of behavioral symptoms. Biol Psychiatry. 1982;17(3):317-326.
19. Matthews SG. Early programming of the hypothalamo-pituitary-adrenal axis. Trends Endocrinol Metab. 2002;13(9):373-380.
20. Vythilingam M, Heim C, Newport J, et al. Childhood trauma associated with smaller hippocampal volume in women with major depression. Am J Psychiatry. 2002;159(12):2072-2080.
21. Holsboer F. The corticosteroid receptor hypothesis of depression. Neuropsychopharmacology. 2000;23(5):477-501.
22. Essex MJ, Klein MH, Cho E, Kalin NH. Maternal stress beginning in infancy may sensitize children to later stress exposure: effects on cortisol and behavior. Biol Psychiatry. 2002;52(8):776-784.
23. Kaufman J, Plotsky PM, Nemeroff CB, Charney DS. Effects of early adverse experiences on brain structure and function: clinical implications. Biol Psychiatry. 2000;48(8):778-790.
24. Meaney MJ. Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations. Annu Rev Neurosci. 2001;24:1161-1192.
25. Nemeroff CB. The neurobiology of depression. Sci Am. 1998;278(6):42-49.
26. Newport DJ, Stowe ZN, Nemeroff CB. Parental depression: animal models of an adverse life event, Am J Psychiatry. 2002;159(8):1265-1283.
27. Arato M. Banki CM, Nemeroff CB, Bissette G. Hypothalamic-pituitary- adrenal axis and suicide. Ann N Y Acad Sci. 1986;487:263-270.
28. Mann JJ. The neurobiology of suicide. Nat Med. 1998;4(1):25-30.
29. Dinan TG. Glucocorticoids and the genesis of depressive illness. A psychobiological model. Br J Psychiatry. 1994;164(3):365-371.
30. van Praag HM. Can stress cause depression? Prog Neuropsychopharmacol Biol Psychiatry. 2004;28(5):891-907.
31. Westrin A, Nimeus A. The dexamethasone suppression test and CSF-5-HIAA in relation to suicidality and depression in suicide attempters, Eur Psychiatry. 2003;18(4):166-171.