Glucose transport is equally sensitive to insulin stimulation, but basal and insulin-stimulated transport is higher, in human omental compared with subcutaneous adipocytes

Metabolism: Clinical and Experimental

Volumn 54, Issue 6, 2005, Pages 781-785

  Westergren, Hanna ^a   Danielsson, Anna ^a   Nystrom, Fredrik H ^a   Strålfors, Peter ^a  

^a LINKÖPING UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; GLUCOSE TRANSPORTER 4; INSULIN;

ADIPOCYTE; ADULT; AGED; ARTICLE; BODY FAT; CELL ISOLATION; CLINICAL ARTICLE; COMPARATIVE STUDY; CONCENTRATION (PARAMETERS); CONCENTRATION RESPONSE; CORRELATION ANALYSIS; FEMALE; GLUCOSE TRANSPORT; HUMAN; INSULIN RESISTANCE; MORBIDITY; OMENTUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENSITIVITY ANALYSIS; STIMULATION; SUBCUTANEOUS FAT;

ADIPOCYTES; ADULT; AGED; BIOLOGICAL TRANSPORT; FEMALE; GLUCOSE; GLUCOSE TRANSPORTER TYPE 4; HUMANS; INSULIN; MIDDLE AGED; MONOSACCHARIDE TRANSPORT PROTEINS; MUSCLE PROTEINS; OMENTUM; SKIN;

EID: 19544394297     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.metabol.2005.01.021     Document Type: Article

References (17)

1. A.H. Kissebah, and G.R. Krakower Regional adiposity and morbidity Physiol Rev 74 1994 761 811
2. B.L. Wajchenberg Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome Endrocr Rev 21 2000 697 738
3. C.T. Montague, J.B. Prins, and L. Sanders Depot-related gene expression in human subcutaneous and omental adipocytes Diabetes 47 1998 1384 1391
4. A. Marette, P. Mauriege, and B. Marcotte Regional variation in adipose tissue insulin action and GLUT4 glucose transporter expression in severely obese premenopausal women Diabetologia 40 1997 590 598
5. P. Arner, L. Hellström, H. Wahrenberg, and M. Bronnegard beta-Adrenoreceptor expression in human fat cells from different regions J Clin Invest 86 1990 1595 1600
6. M. Rebuffé-Scrive, B. Andersson, L. Olbe, and P. Björntorp Metabolism of adipose tissue in intraabdominal depots of nonobese men and women Metabolism 38 1989 453 458
7. J.R. Zierath, J.N. Livingstone, and A. Thörne Regional difference in insulin inhibition of non-esterified fatty acid release from human adipocytes: relation to insulin receptor phosphorylation and intracellular signalling through the insulin receptor substrate-1 pathway Diabetologia 41 1998 1343 1354
8. J. Bolinder, L. Kager, J. Östman, and P. Arner Differences at the receptor and postreceptor levels between human omental and subcutaneous adipose tissue in the action of insulin on lipolysis Diabetes 32 1983 117 123
9. J.N. Livingstone, K.M. Lerea, J. Bolinder, L. Kager, L. Backman, and P. Arner Binding and molecular weight properties of the insulin receptor from omental and subcutaneous adipocytes in human obesity Diabetologia 27 1984 447 453
10. M. Stolic, A. Russel, and L. Hurtley Glucose uptake and insulin action in human adipose tissue-influence of BMI, anatomical depot and body fat distribution Int J Obes 26 2002 17 23
11. A. Danielsson, A. Öst, and E. Lystedt Insulin resistance in human adipocytes downstream of IRS1 after surgical cell isolation, but at the level of phosphorylation of IRS1 in type 2 diabetes FEBS J 272 2005 141 151
12. H. Ruan, M.J. Zarnowski, S.W. Cushman, and H.F. Lodish Standard isolation of primary adipose cells from mouse epididymal fat pads induces inflammatory mediators and down-regulates adipocyte genes J Biol Chem 278 2003 47585 47593
13. P. Strålfors, and R.C. Honnor Insulin-induced dephosphorylation of hormone-sensitive lipase. Correlation with lipolysis and cAMP-dependent protein kinase activity Eur J Biochem 182 1989 379 385
14. M. Karlsson, H. Thorn, and A. Danielsson Colocalization of insulin receptor and insulin receptor substrate-1 to caveolae in primary human adipocytes. Cholesterol depletion blocks insulin signalling for metabolic and mitogenic control Eur J Biochem 271 2004 2471 2479
15. K.A. Virtanen, P. Lönnroth, and R. Parkkola Glucose uptake and perfusion in subcutaneous and visceral adipose tissue during insulin stimulation in nonobese and obese humans J Clin Endocrinol Metab 87 2002 3902 3910
16. V.v. Harmelen, A. Dicker, and M. Ryden Increased lipolysis and decreased leptin production by human omental as compared with subcutaneous preadipocytes Diabetes 51 2002 2029 2036
17. F. Kreier, E. Fliers, and P.J. Voshol Selective parasympathetic innervation of subcutaneous and intra-abdominal fat-functional implications J Clin Invest 110 2002 1243 1250