Synthesis of a tetrahydropyran NK1 receptor antagonist via asymmetric conjugate addition

Journal of Organic Chemistry

Volumn 70, Issue 11, 2005, Pages 4409-4413

  Huffman, Mark A ^a   Smitrovich, Jacqueline H ^a   Rosen, Jonathan D ^a   Boice, Geneviève N ^a   Qu, Chuanxing ^a   Nelson, Todd D ^a   McNamara, James M ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADDITION REACTIONS; AROMATIC COMPOUNDS; CARBOXYLIC ACIDS; ESTERS; REDUCTION; STEREOCHEMISTRY; SUBSTITUTION REACTIONS; SYNTHESIS (CHEMICAL); THERMODYNAMICS;

CONJUGATE ADDITION; ESTER REDUCTION; STEREOSELECTIVE ACETAL SUBSTITUTION;

OXYGEN;

1 [2 [1 [3,5 BIS(TRIFLUOROMETHYL)PHENYL]ETHOXY] 3 (3,4 DIFLUOROPHENYL) 4 TETRAHYDRO 2H PYRAN 4 YLMETHYL] 3 METHYLPIPERIDINE 3 CARBOXYLIC ACID; ACETAL; ESTER; LACTONE; NEUROKININ 1 RECEPTOR ANTAGONIST; PIPERIDINE DERIVATIVE; PSEUDOEPHEDRINE; TETRAHYDROPYRAN DERIVATIVE; UNCLASSIFIED DRUG; 1 (2 (R) (1 (R) (3,5 BIS(TRIFLUOROMETHYL)PHENYL)ETHOXY) 3 (R) (3,4 DIFLUOROPHENYL) 4 (R) TETRAHYDRO 2H PYRAN 4 YLMETHYL) 3 (R) METHYLPIPERIDINE 3 CARBOXYLIC ACID; 1-(2-(R)-(1-(R)-(3,5-BIS(TRIFLUOROMETHYL)PHENYL)ETHOXY)-3-(R)-(3,4-DIFLUOROPHENYL)-4-(R)-TETRAHYDRO-2H-PYRAN-4-YLMETHYL)-3-(R)-METHYLPIPERIDINE-3-CARBOXYLIC ACID; NEUROKININ 1 RECEPTOR; PYRAN DERIVATIVE;

ADDITION REACTION; ALKYLATION; ARTICLE; ASYMMETRIC SYNTHESIS; CHIRALITY; CONJUGATION; GEOMETRY; MICHAEL ADDITION; REDUCTION; STEREOCHEMISTRY; SUBSTITUTION REACTION; THERMODYNAMICS; CHEMICAL STRUCTURE; CHEMISTRY; COMBINATORIAL CHEMISTRY; DRUG ANTAGONISM; STEREOISOMERISM; SYNTHESIS;

ALKYLATION; COMBINATORIAL CHEMISTRY TECHNIQUES; MOLECULAR STRUCTURE; PIPERIDINES; PYRANS; RECEPTORS, NEUROKININ-1; STEREOISOMERISM;

EID: 19544371036     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo0504161     Document Type: Article

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