CYP2E1 inhibition enhances mallory body formation

Experimental and Molecular Pathology

Volumn 78, Issue 3, 2005, Pages 207-211

  Bardag Gorce, Fawzia ^a   Wilson, L ^a   Nan, Li ^a   Li, Jun ^a   French, Barbara A ^a   Morgan, Timothy R ^a   Morgan, Kengathevy ^a   French, Samuel W ^a  

^a HARBOR UCLA MEDICAL CENTER   (United States)

Author keywords

Detoxification; Drug primed mice

Indexed keywords

1,4 DIHYDRO 2,4,6 TRIMETHYL 3,5 PYRIDINEDICARBOXYLIC ACID DIETHYL ESTER; CLOMETHIAZOLE; CYTOCHROME P450 2E1; CYTOCHROME P450 INHIBITOR; LIVER ENZYME;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DETOXIFICATION; DRUG ELIMINATION; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; GENE OVEREXPRESSION; KNOCKOUT MOUSE; LIVER LEVEL; MALE; MALLORY BODY; MOUSE; NONHUMAN; WESTERN BLOTTING; WILD TYPE;

ANIMALS; BLOTTING, WESTERN; CHLORMETHIAZOLE; CYTOCHROME P-450 CYP2E1; DIHYDROPYRIDINES; ENZYME INHIBITORS; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; HEPATOCYTES; INCLUSION BODIES; LIVER DISEASES; MALE; MICE; MICE, INBRED C3H; MICE, KNOCKOUT; UBIQUITIN;

EID: 19544362578     PISSN: 00144800     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yexmp.2005.01.006     Document Type: Article

References (16)

1. E. Albano, S.W. French, and M. Ingelman-Sundberg Hydroxyethyl radicals in ethanol hepatotoxicity Front. Biosci. 4 1999 D533 D540
2. F. Bardag-Gorce, Q.X. Yuan, J. Li, B.A. French, C. Fang, M. Ingelman-Sundberg, and S.W. French The effect of ethanol induced cytochrome P4502E1 on the inhibition of proteasome activity by alcohol Biochem. Biophys. Res. Commun. 279 1 2000 23 29
3. F. De Matteis, and G.S. Marks Cytochrome P450 and its interactions with the heme biosynthetic pathway Can. J. Physiol. Pharmacol. 74 1 1996 1 8
4. D. Djordjevic, J. Nikolic, and V. Stefanovic Ethanol interactions with other cytochrome P450 substrates including drugs, xenobiotics, and carcinogens Pathol. Biol. (Paris) 46 10 1998 760 770 (Dec.)
5. S.W. French, K. Wong, L. Jui, E. Albano, A.L. Hagbjork, and M. Ingelman-Sundberg Effect of ethanol on cytochrome P450 2E1 (CYP2E1), lipid peroxidation, and serum protein adduct formation in relation to liver pathology pathogenesis Exp. Mol. Pathol. 58 1 1993 61 75 (Feb.)
6. S.W. French, M. Morimoto, R.C. Reitz, D. Koop, B. Klopfenstein, K. Estes, P. Clot, M. Ingelman-Sundberg, and E. Albano Lipid peroxidation, CYP2E1 and arachidonic acid metabolism in alcoholic liver disease in rats J. Nutr. 127 5 Suppl. 1997 907S 911S (May)
7. D. Gergel, V. Misik, P. Riesz, and A.I. Cederbaum Inhibition of rat and human cytochrome P4502E1 catalytic activity and reactive oxygen radical formation by nitric oxide Arch. Biochem. Biophys. 337 2 1997 239 250
8. Z. Gouillon, D. Lucas, J. Li, A.L. Hagbjork, B.A. French, P. Fu, C. Fang, M. Ingelman-Sundberg, T.M. Donohue Jr, and S.W. French Inhibition of ethanol-induced liver disease in the intragastric feeding rat model by chlormethiazole Proc. Soc. Exp. Biol. Med. 224 4 2000 302 308 (Sep.)
9. I. Kessova, and A.I. Cederbaum CYP2E1: biochemistry, toxicology, regulation and function in ethanol-induced liver injury Curr. Mol. Med. 3 6 2003 509 518
10. U.K. Laemmli Cleavage of structural proteins during the assembly of the head of bacteriophage T4 Nature 227 1970 680 685
11. S.S. Lee, J.T. Buters, T. Pineau, P. Fernandez-Salguero, and F.J. Gonzalez Role of CYP2E1 in the hepatotoxicity of acetaminophen J Biol Chem 271 20 1996 12063 12067
12. Lieber Interaction of ethanol with drugs, hepatotoxic agents, carcinogens and vitamins Alcohol Alcohol 25 2-3 1990 157 176
13. G.S. Marks, S.A. McCluskey, J.E. Mackie, D.S. Riddick, and C.A. James Disruption of hepatic heme biosynthesis after interaction of xenobiotics with cytochrome P-450 FASEB J. 2 12 1988 2774 2783
14. G.S. Marks, S.A. McCluskey, J.E. Mackie, D.S. Riddick, and C.A. James Interaction of chemicals with cytochrome P-450: implications for the porphyrinogenicity of drugs Clin. Biochem. 22 3 1989 169 175
15. K. Morgan, S.W. French, and T.R. Morgan Production of a cytochrome P450 2E1 transgenic mouse and initial evaluation of alcoholic liver damage Hepatology 310 2002 122 134
16. Q.X. Yuan, N. Marceau, B.A. French, P. Fu, and S.W. French Mallory body induction in drug-primed mouse liver Hepatology 24 3 1996 603 612