Acute exacerbation of hepatitis in liver cirrhosis with very high levels of alpha-fetoprotein but no occurrence of hepatocellular carcinoma

Korean Journal of Internal Medicine

Volumn 20, Issue 1, 2005, Pages 80-85

  Bae, Jin Soo ^a   Park, Sang Jong ^a   Park, Kwang Bo ^a   Paik, So Ya ^a   Ryu, Jin Kyung ^a   Choi, Chang Kyu ^a   Hwang, Tae Joon ^a  

^a Boondang Jaesaeng General Hospital   (South Korea)

Author keywords

Alpha Fetoprotein (AFP); Hepatitis; Hepatocellular carcinoma; Liver cirrhosis

Indexed keywords

ALPHA FETOPROTEIN; AMINOTRANSFERASE; ANTIVIRUS AGENT; HEPATITIS B SURFACE ANTIBODY; HEPATITIS B SURFACE ANTIGEN; INTERFERON; LAMIVUDINE; RIBAVIRIN; VIRUS RNA;

ADULT; AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; CASE REPORT; DIAGNOSTIC ACCURACY; DIAGNOSTIC IMAGING; DISEASE EXACERBATION; FEMALE; HEPATITIS B; HEPATITIS B VIRUS; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; MALE; NONHUMAN; PROTEIN BLOOD LEVEL;

EID: 19444385880     PISSN: 12263303     EISSN: None     Source Type: Journal    
DOI: 10.3904/kjim.2005.20.1.80     Document Type: Article

References (20)

1. Parkin DM, Stjrnsward J, Muir CS. Estimates of the worldwide frequency of twelve major cancer. Bull World Helath Organ 62: 163-182, 1984
2. Kubo Y, Okuda K, Musha H, Nakashima T. Detection of hepatocellular carcinoma during a clinical follow-up of chronic liver disease: observation in 31 patients. Gastroenterology 74:578-582, 1978
3. Oka H, Kurioka N, Kim K, Kanno T, Kuroki T, Mizoguchi Y, Kobayashi K. Prospective study of early detection of hepatocellular carcinoma in patients with cirrhosis. Hepatology 12:680-687, 1990
4. Shinagawa T, Ohto M, Kimura K, Tsunetomi S, Morita M, Saisho H, Tsuchiya Y, Saotomo N, Karasawa E, Miki M. Diagnosis and clinical features of small hepatocellular carcinoma with emphasis on the utility of real-time ultrasonography: a study in 51 patients. Gastroenterology 86:495-502, 1984
5. Ebara M, Ohto M, Shinagawa T, Sugiura N, Kimura K, Matsutani S, Morita M, Saisho H, Tsuchiya Y, Okuda K. Natural history of minute hepatocellular carcinoma smaller than three centimeters complicating cirrhosis: a study in 22 patients. Gastroenterology 90:289-298, 1986
6. Bloomer JR, Waldmann TA, McIntire KR, Klatskin G. alpha-fetoprotein in nonneoplastic hepatic disorders. JAMA 233:38-41, 1975
7. Alpert E, Feller ER. alpha-fetoprotein (AFP) in benign liver disease: evidence that normal liver regeneration does not induce AFP synthesis. Gastroenterology 74:856-858, 1978
8. Okuda K. Early recognition of hepatocellular carcinoma. Hepatology 6:729-738, 1986
9. Lok ASF, Lai CL. alpha-fetoprotein monitoring in Chinese patients with chronic hepatitis B virus infection: role in the early detection of hepatocellular carcinoma. Hepatology 9:110-115, 1989
10. Yoshima H, Mizuochi T, Ishii M, Kobata A. Structure of the asparagine-linked sugar chains of alpha-fetoprotein purified from huma ascites fluid. Cancer Res 40:4276-4281, 1980
11. Cheema A, Hirschtritt T, van Thiel D. Markedly elevated alpha-fetoprotein levels without hepatocellular carcinoma [Abstract]. Am J of Gastroenterology 98:(Suppl), 2003
12. Song BC, Suh DJ, Yang SH, Lee HC, Chung YH, Sung KB, Lee YS. Lens culinaris agglutinin reactive alpha-fetoprotein as a prognostic marker in patients with hepatocellular carcinoma undergoing transcatheter arterial chemoembolization. J Clin Gastroenterol 35: 398-402, 2002
13. Buamah PK, Haris R, James OF, Skillen AW. Lentil-lectin-reactive alpha-fetoprotein in the differential diagnosis of benign and malignant liver disease. Clin Chem 32:2083-2084, 1986
14. Taketa K, Ichikawa E, Akamatsu K, Ohta Y, Sekiya C, Namiki M, Takami H, Kaneda H, Higashino K, Taga H. Increased asialo-alpha-fetoprotein in patients with alpha-fetoprotein-producing tumors: demonstration by affinity electrophoresis with erythroagglutinating phytohemagglutinin of Phaseolus vulgaris lectin. Tumour Biol 6:533-544, 1985
15. Du MQ, Hutchinson WL, Johnson PJ, Williams R. Differential alpha-fetoprotein lectin binding in hepatocellular carcinoma: diagnostic utility at low serum levels. Cancer 67:476-480, 1991
16. Taketa K, Ichikawa E, Taga H, Hirai H. Antibody-affinity blotting, a sensitive technique for the detection of alpha-fetoprotein separated by lectin affinity electrophoresis in agarose gels. Electrophoresis 6:492-497, 1985
17. Chopra S, Griffin PH. Laboratory tests and diagnostic procedures in evaluation of liver disease. Am J Med 79:221-230, 1985
18. Nakata K, Khan KN, Nagataki S. Transcatheter arterial embolization of hepatic neoplasms. Crit Rev Oncol Hematol 13:93-105, 1992
19. van Thiel DH, Carr BI, Yokoyama I, Iwatsuki S, Starzl TE. Liver transplantation as a treatment of hepatocellular carcinoma. In: Tabor E, di Bisceglie AM, Purcell RH, eds. Etiology, pathology, and treatment of hepatocellular carcinoma in North America. Houston, Gulf, 1992
20. Sato Y, Nakata K, Kato Y, Shima M, Ishii N, Koji T, Taketa K, Endo Y, Nagataki S. Early recognition of hepatocellular carcinoma based on altered profiles of alpha-fetoprotein. N Eng J Med 328:1802-1806, 1993