Linkage study of the glucagon receptor gene with type 2 diabetes mellitus in Italians

Metabolism: Clinical and Experimental

Volumn 54, Issue 6, 2005, Pages 786-787

  Gragnoli, Claudio ^a,b,c   Milord, Edrice ^d   Habener, Joel Francis ^a,b,e  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF ROME TOR VERGATA   (Italy)

^d UNIVERSITY OF UDINE   (Italy)

^e HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCAGON RECEPTOR; GLYCINE; SERINE;

ARTICLE; CALCULATION; CHROMOSOME 17Q; FAMILY; GENE FREQUENCY; GENE IDENTIFICATION; GENE LOCUS; GENETIC LINKAGE; GENETIC TRAIT; GENOME; GENOTYPE; HUMAN; ITALY; LINKAGE ANALYSIS; MAJOR CLINICAL STUDY; MUTATION; NON INSULIN DEPENDENT DIABETES MELLITUS; NONPARAMETRIC TEST; PATHOGENESIS; PRIORITY JOURNAL;

DIABETES MELLITUS, TYPE 2; HUMANS; LINKAGE (GENETICS); RECEPTORS, GLUCAGON;

EID: 19444383497     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.metabol.2005.01.022     Document Type: Article

References (13)

1. A. Parker A gene conferring susceptibility to type 2 diabetes in conjunction with obesity is located on chromosome 18p11 Diabetes 50 2001 675 680
2. S. Lok The human glucagon receptor encoding gene: structure, cDNA sequence and chromosomal localization Gene 140 1994 203 209
3. J. Hager A missense mutation in the glucagon receptor gene is associated with non-insulin-dependent diabetes mellitus Nat Genet 9 1995 299 304
4. S.C. Gough Mutation of the glucagon receptor gene and diabetes mellitus in the UK: association or founder effect? Hum Mol Genet 4 1995 1609 1612
5. T. Fujisawa A mutation in the glucagon receptor gene (Gly40Ser): heterogeneity in the association with diabetes mellitus Diabetologia 38 1995 983 985
6. X. Huang, M. Orho, M. Lehto, and L. Groop Lack of association between the Gly40Ser polymorphism in the glucagon receptor gene and NIDDM in Finland Diabetologia 38 1995 1246 1248
7. G. Babadjanova, M. Reincke, P. Mora, A. Chuchalin, and B. Allolio Polymorphism of the glucagon receptor gene and non-insulin-dependent diabetes mellitus in the Russian population Exp Clin Endocrinol Diabetes 105 1997 225 226
8. C. Gragnoli Maturity-onset diabetes of the young due to a mutation in the hepatocyte nuclear factor-4 alpha binding site in the promoter of the hepatocyte nuclear factor-1 alpha gene Diabetes 46 1997 1648 1651
9. C. Gragnoli, B.N. Cockburn, F. Chiaramonte, A. Gorini, G. Marietti, and G. Marozzi Early-onset type II diabetes mellitus in Italian families due to mutations in the genes encoding hepatic nuclear factor 1a and glucokinase Diabetologia 44 2001 1326 1329
10. C. Gragnoli, V. Stanojevic, A. Gorini, G. Menzinger von Preussental, M.K. Thomas, and J.F. Habener IPF-1/MODY4 gene missense mutation in an Italian family with type 2 diabetes and gestational diabetes Metabolism 2005 [in press]
11. G.R. Abecasis, S.S. Cherny, W.O. Cookson, and L.R. Cardon Merlin-rapid analysis of dense genetic maps using sparse gene flow trees Nat Genet 30 2002 97 101
12. N. Risch Linkage strategies for genetically complex traits: II. The power of affected relative pairs [see comments] Am J Hum Genet 46 1990 229 241
13. G. Tonolo Physiological and genetic characterization of the Gly40Ser mutation in the glucagon receptor gene in the Sardinian population. The Sardinian Diabetes Genetic Study Group Diabetologia 40 1997 89 94