In vitro and in vivo characterization of a newly developed clonidine transdermal patch for treatment of attention deficit hyperactivity disorder in children

Biological and Pharmaceutical Bulletin

Volumn 28, Issue 2, 2005, Pages 305-310

  Ke, Guang Ming ^a   Wang, Li ^b   Xue, Hui Yong ^b   Lu, Wan Liang ^c   Zhang, Xuan ^c   Zhang, Qiang ^c   Guo, Hong You ^a  

^a BEIJING UNIVERSITY OF CHEMICAL TECHNOLOGY   (China)

^b Beijing Kangbeide Pharmaceuticals Ltd   (China)

^c PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

Clonidine; KBD transdermal therapeutic system (TTS); LC MS; Pharmacokinetics; Rabbit; Transdermal penetration

Indexed keywords

CLONIDINE; ETHYLENE VINYL ACETATE COPOLYMER; KBD TTS;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATTENTION DEFICIT DISORDER; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG HALF LIFE; DRUG PENETRATION; DRUG RELEASE; ELUTION; GUINEA PIG; HYPERTENSION; IN VITRO STUDY; IN VIVO STUDY; ION MONITORING; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NONHUMAN; PARTITION COEFFICIENT; QUANTITATIVE ANALYSIS; RABBIT; SKIN; SOLID PHASE EXTRACTION; STATISTICAL SIGNIFICANCE; STEADY STATE; TRANSDERMAL DRUG ADMINISTRATION; TRANSDERMAL PATCH; ANIMAL; CHILD; COMPARATIVE STUDY; HUMAN; INTRADERMAL DRUG ADMINISTRATION; MALE;

ADMINISTRATION, CUTANEOUS; ANIMALS; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; CHILD; CLONIDINE; GUINEA PIGS; HUMANS; MALE; RABBITS;

EID: 19444381675     PISSN: 09186158     EISSN: None     Source Type: Journal    
DOI: 10.1248/bpb.28.305     Document Type: Article

References (15)

1. Gilman A., "Goodman & Gilman's the Pharmacological Basis of Therapeutics," 10th ed., McGraw-Hill, New York, 2001.
2. Hamilton C. A., Pharmacol. Ther., 54, 231-248 (1992).
3. Biederman J., Spencer T., Wilens T., Int. J. Neuropsychopharmacol., 7, 77-97 (2004).
4. Kreilgaard M., Pedersen E. J., Jaroszewski J. W., J. Control. Release, 69, 421-433 (2000).
5. Girault J., Fourtillan J. B., Biomed. Environ. Mass. Spectrom., 17, 443-448 (1988).
6. Yamahata T., Dote S., Ozawa Y., Nishikawa H., Maeda S., J. Chromatogr. B, Biomed. Appl., 653, 92-97 (1994).
7. Arndts D., Stahle H., J. Pharmacol. Methods, 6, 109-120 (1981).
8. Wilczynska-Wojtulewicz I., Sadlej-Sosnowska N., J. Chromatogr., 367, 434-437 (1986).
9. Naidong W., Bu H., Chen Y. L., Shou W. Z., Jiang X., Halls T. D., J. Pharm. Biomed. Anal., 28, 1115-1126 (2002).
10. Ebihara A., Fujimura A., Ohashi K., Shiga T., Kumagai Y., Nakashima H., Kotegawa T., J. Clin. Pharmacol, 33, 1188-1191 (1993).
11. Fujimura A., Ebihara A., Shiga T., Kumagai Y., Ohashi K., Nakashima H., Kotegawa T., J. Clin. Pharmacol., 33, 1192-1200 (1993).
12. Fujimura A., Ebihara A., Ohashi K., Shiga T., Kumagai Y., Nakashima H., Kotegawa T., J. Clin. Pharmacol., 34, 260-265 (1994).
13. Fujimura A., Sasaki M., Harada K., Kumagai Y., Ohashi K., Ebihara A., J. Clin. Pharmacol., 36, 892-896 (1996).
14. Lonnqvist P. A., Bergendahl H. T., Eksborg S., Anesthesiology, 81, 1097-1101 (1994).
15. 〈http://www.rxlist.com/cgi/generic/clonidin_cp.htm〉, last revised on 31 December 2003.