Low postoperative hematocrit increases cerebrovascular damage after hypothermic circulatory arrest

Pediatric Critical Care Medicine

Volumn 6, Issue 3, 2005, Pages 319-326

  Shum Tim, Dominique ^a   MacDonald, Derek ^a   Takayuki, Saito ^a   Laliberté, Eric ^a   Chen, Jenny ^a   Jamal, Al Maleek ^a   Philip, Anie ^a   Platt, Robert ^a  

^a MONTREAL CHILDREN S HOSPITAL   (Canada)

Author keywords

Anemia; Brain ischemia; Cardiac surgery; Cardiopulmonary bypass; Hypothermia; Pediatrics

Indexed keywords

CASPASE 3; CYTOCHROME C OXIDASE; OXYHEMOGLOBIN; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CARDIOPULMONARY BYPASS; CENTRAL VENOUS PRESSURE; CEREBROVASCULAR DISEASE; CONTROLLED STUDY; HEART ARREST; HEMATOCRIT; IMMUNOHISTOCHEMISTRY; INFRARED SPECTROSCOPY; MEAN ARTERIAL PRESSURE; NONHUMAN; ONCOTIC PRESSURE; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; RANDOMIZATION; SCORING SYSTEM; SURVIVAL; SWINE; TISSUE OXYGENATION; WEIGHT GAIN;

ANIMALS; BODY WATER; BODY WEIGHT; CARDIOPULMONARY BYPASS; CASPASE 3; CASPASES; CEREBRAL CORTEX; CEREBROVASCULAR DISORDERS; ELECTRIC IMPEDANCE; HEMATOCRIT; HEMOGLOBINS; HYPOTHERMIA, INDUCED; OXYGEN CONSUMPTION; OXYHEMOGLOBINS; POSTOPERATIVE PERIOD; SWINE; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1;

EID: 19444371912     PISSN: 15297535     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.PCC.0000161070.63957.E1     Document Type: Article

References (33)

1. Laverdière C, Gauvin F, Hébert PC, et al: Survey on transfusion practices of pediatric intensivists. Pediatr Crit Care Med 2002; 3:335-340
2. Hébert PC, Wells G, Martin C, et al: Variation in red cell transfusion practice in the intensive care unit: A multicentre cohort study. Crit Care 1999; 3:57-63
3. Shum-Tim D, Tchervenkov CI, Jamal AM, et al: Systemic steroid pretreatment improves cerebral protection after circulatory arrest. Ann Thorac Surg 2001; 72:1465-1472
4. Institute of Laboratory Animal Resources, Commission on Life Science, National Research Council: Guide for the Care and Use of Laboratory Animals. Washington, DC, National Academy Press, 1996
5. Krupinski J, Kumar P, Kumar S, et al: Increased expression of TGF-β1 in brain tissue after ischemic stroke in humans. Stroke 1996; 27:852-857
6. Henrich-Noack P, Prehn JH, Krieglstein J: TGF-beta 1 protects hippocampal neurons against degeneration caused by transient global ischemia. Dose-response relationship and potential neuroprotective mechanisms. Stroke 1996; 27:1609-1615
7. Hébert PC, Wells G, Blajchman MA, et al: A multicenter, randomized, controlled clinical trail of transfusion requirements in critical care. N Engl J Med 1999; 340:409-417
8. Hébert PC, Yetisir E, Martin C, et al: Is a low transfusion threshold safe in critically ill patients with cardiovascular diseases? Crit Care Med 2001; 29:227-234
9. Shin'oka T, Shum-Tim D, Jonas RA, et al: Higher hematocrit improves cerebral outcome after deep hypothermic circulatory arrest. J Thorac Cardiovasc Surg 1996; 112: 1610-1621
10. Jonas RA, Wypij D, Roth SJ, et al: The influence of hemodilution on outcome after hypothermic cardiopulmonary bypass: Results of a randomized trial in infants. J Thorac Cardiovasc Surg 2003; 126:1765-1774
11. Kwiatkowski JL, Manno CS: Blood transfusion support in pediatric cardiovascular surgery. Transfusion Science 1999; 21:63-72
12. Hébert PC, Wells G, Tweeddale M, et al: Does transfusion practice affect mortality in critically ill patients? Am J Respir Crit Care Med 1997; 155:1618-1623
13. Bratton SL: Packed red blood cell transfusions for critically ill pediatric patients: When and for what conditions? J Pediatr 2003; 142:95-97
14. Murphy MF, Wallington TB, Kelsey P, et al: British committee for standards in haematology, blood transfusion task force. Guidelines for the clinical use of red blood cell transfusion. Br J Haematol 2001; 113:24-31
15. Dearden NM: Mechanisms and prevention of secondary brain damage during intensive care. Clin Neuropathol 1998; 17:221-228
16. Jones PA, Andrews PJ, Midgley S, et al: Measuring the burden of secondary insults in head-injured patients during intensive care. J Neurosurg Anesthesiol 1994; 6:4-14
17. Marmarou A, Anderson RL, Ward JD, et al: Impact of ICP instability and hypotension on outcome in patients with severe head trauma. J Neurosurg 1991; 75:S59-S66
18. Steen RG, Xiong X, Mulhern RK, et al: Subtle brain abnormalities in children with sickle cell disease: Relationship to blood hematocrit. Ann Neurol 1999; 45:279-286
19. Micheloyannis S, Papadaki F, Jannopoulos A: The effect of blood transfusion on Alpha EEG activity in thalassemic patients. Eur Neurol 1991; 31:131-135
20. Young RS, Rannels DE, Hilmo A, et al: Severe anemia in childhood presenting as transient ischemic attacks. Stroke 1983; 14: 622-623
21. Reasoner DK, Ryu KH, Hindman BJ, et al: Marked hemodilution increases neurologic injury after focal cerebral ischemia in rabbits. Anesth Analg 1996; 82:61-67
22. Lee SH, Heros RC, Mullan JC, et al: Optimum degree of hemodilution for brain protection in a canine model of focal cerebral ischemia. J Neurosurg 1994; 80:469-475
23. DeWitt DS, Prough DS, Taylor CL, et al: Reduced cerebral blood flow, oxygen delivery, and electroencephalographic activity after traumatic brain injury and mild hemorrhage in cats. J Neurosurg 1992; 76:812-821
24. Hardy JF, Martineau R, Couturier A, et al: Influence of haemoglobin concentration after extracorporeal circulation on mortality and morbidity in patients undergoing cardiac surgery. Br J Anaesth 1998; 81:38-45
25. Carson JL, Noveck H, Berlin JA, et al: Mortality and morbidity in patients with very low postoperative Hb levels who decline blood transfusion. Transfusion 2002; 42:812-818
26. Alkalay AL, Galvis S, Ferry DA, et al: Hemodynamic changes in anemic premature infants: Are we allowing the hematocrits to fall too low? Pediatrics 2003; 112:838-845
27. Carson JL, Duff A, Poses RM, et al: Effect of anaemia and cardiovascular disease on surgical mortality and morbidity. Lancet 1996; 348:1055-1060
28. Carson J: Morbidity risk assessment in the surgically anemic patient. Am J Surg 1995; 170:32S-36S
29. Doss DN, Estafanous FG, Ferrario CM, et al: Mechanism of systemic vasodilation during normovolemic hemodilution. Anesth Analg 1995; 81:30-34
30. Sakamoto T, Jonas RA, Stock UA, et al: Utility and limitations of near-infrared spectroscopy during cardiopulmonary bypass in a piglet model. Pediatr Res 2001; 49:770-776
31. Shinoka T, Nollert G, Shum-Tim D, et al: Utility of near-infrared spectroscopic measurements during deep hypothermic circulatory arrest. Ann Thorac Surg 2000; 69: 578-583
32. Shum-Tim D, Nagashima M, Shinoka T, et al: Postischemic hyperthermia exacerbates neurologic injury after deep hypothermic circulatory arrest. J Thorac Cardiovasc Surg 1998; 116:780-792
33. Mujsce DJ, Towfighi J, Yager JY, et al: Neurological aspects of hypothermic circulatory arrest in newborn dogs. Acta Neuropathol 1993; 85:190-8