Robustness in gene circuits: Clustering of functional responses

Proceedings of the American Control Conference

Volumn 6, Issue , 2005, Pages 4411-4416

  Dunlop, Mary J ^a   Wall, Michael E ^b  

^a California Institute of Technology   (United States)

^b LOS ALAMOS NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGY; COMPUTER SIMULATION; FEEDBACK; GENES; MATHEMATICAL MODELS; PARAMETER ESTIMATION; ROBUSTNESS (CONTROL SYSTEMS);

CONTROL LAWS; FEED-FORWARD LOOP; FUNCTIONAL RESPONSE; GENE CIRCUITS;

CONTROL SYSTEMS;

EID: 19444370544     PISSN: 07431619     EISSN: None     Source Type: Conference Proceeding    
DOI: None     Document Type: Conference Paper

References (11)

1. M.R. Atkinson, M.A. Savageau, J.T. Myers, and A.J. Ninfa. Development of genetic circuitry exhibiting toggle switch or oscillatory behavior in Escherichia coli. Cell, 113:597-607, 2003.
2. M. Elowitz and S. Leibler. A synthetic oscillatory network of transcriptional regulators. Nature, 403:335-338, 2000.
3. T.S. Gardner, C.R. Cantor, and J.J. Collins. Construction of a genetic toggle switch in Escherichia coli. Nature, 403:339-342, 2000.
4. D.S. Hochbaum and D.B. Shmoys. A best possible approximation algorithm for the k-center problem. Math Oper Res, 10:180-184, 1985.
5. S. Mangan and U. Alon. Structure and function of the feed-forward loop network motif. Proc Natl Acad Sci, 100:11980-11985, 2003.
6. J.D. Murray. Mathematical Biology I. Springer Verlag, 3rd edition, 2002.
7. M.A. Savageau. Design of molecular control mechanisms and the demand for gene expression. Proc Natl Acad Sci, 74:5647-5651, 1977.
8. R. Schleif. Regulation of the L-arabinose operon of Escherichia coli. Trends in Genetics, 16:559-565, 2000.
9. S. Shen-Orr, R. Milo, S. Mangan, and U. Alon. Network motifs in the transcriptional regulation network of Escherichia coli. Nature Genetics, 31:64-68. May 2002.
10. M. Wall, W. Hlavacek, and M. Savageau. Design of gene circuits: Lessons from bacteria. Nature Reviews Genetics, 5:34-42, 2004.
11. M. Wall, A. Rechtsteiner, and L. Rocha. A Practical Approach to Microarray Data Analysis. D.P. Berrar, W. Dubitzky. and M. Granzow, eds. pp. 91-109. Kluwer, Norwell, MA, 2003.