In vitro effects of keyhole limpet hemocyanin in breast and pancreatic cancer in regards to cell growth, cytokine production, and apoptosis

American Journal of Surgery

Volumn 189, Issue 6, 2005, Pages 680-684

  Riggs, Dale R ^a   Jackson, Barbara J ^a   Vona Davis, Linda ^a   Nigam, Ankesh ^a   McFadden, David W ^a  

^a WEST VIRGINIA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Breast cancer; Cellular inhibition and apoptosis; Keyhole limpet hemocyanin; Pancreas cancer

Indexed keywords

CYTOKINE; INTERLEUKIN 12; INTERLEUKIN 2; INTERLEUKIN 6; INTERLEUKIN 8; KEYHOLE LIMPET HEMOCYANIN; TUMOR NECROSIS FACTOR ALPHA;

APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER GROWTH; CANCER INHIBITION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFECT; DRUG MECHANISM; GROWTH INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; PANCREAS CANCER; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; STATISTICAL SIGNIFICANCE;

ADJUVANTS, IMMUNOLOGIC; APOPTOSIS; BREAST NEOPLASMS; CELL LINE, TUMOR; FEMALE; HEMOCYANIN; HUMANS; INTERLEUKINS; MALE; PANCREATIC NEOPLASMS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 19444363663     PISSN: 00029610     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.amjsurg.2004.10.005     Document Type: Article

References (16)

1. J.R. Harris, J. Markl Keyhole limpet hemocyanin: Molecular structure of a potent marine immunoactivator. A review Eur Urol 37 Suppl 3 2000 24 33
2. A.O. Tzianabos Polysaccharide immunomodulators as therapeutic agents Structural aspects and biologic function Clin Microbiol Rev 13 2000 523 533
3. C.A. Olsson, R. Chute, C.N. Rao Immunologic reduction of bladder cancer recurrence rate J Urol 111 1974 173 176
4. D.L. Lamm, J.I. DeHaven, D.R. Riggs Keyhole limpet hemocyanin immunotherapy of murine bladder cancer Urol Res 21 1993 33 37
5. C.D. Jurincic, U. Engelmann, J. Gasch Immunotherapy in bladder cancer with keyhole-limpet hemocyanin A randomized study J Urol 139 1988 723 726
6. C.D. Jurincic-Winkler, K.A. Metz, J. Beuth Keyhole limpet hemocyanin for carcinoma in situ of the bladder A long-term follow-up study Eur Urol 37 Suppl 3 2000 45 49
7. D.L. Lamm, J.I. DeHaven, D.R. Riggs Keyhole limpet hemocyanin immunotherapy of bladder cancer Laboratory and clinical studies Eur Urol 37 Suppl 3 2000 41 44
8. D. Riggs, B. Jackson, L. Vona-Davis In vitro anticancer effects of a novel immunostimulant Keyhole limpet hemocyanin J Surg Res 108 2002 279 284
9. T. Mosmann Rapid colorimetric assay for cellular growth and survival Application to proliferation and cytotoxicity assays J Immunol Methods 65 1983 55 63
10. W.J. Dixon, F.J. Massey Introduction to Statistical Analysis 4th ed. 1983 McGraw-Hill New York
11. J. Ludbrook Multiple comparison procedures updated Clin Exp Pharmacol Physiol 25 1998 1032 1037
12. S. Gluck The expanding role of epirubicin in the treatment of breast cancer Cancer Control 9 2002 16 27
13. M.J. Moore Pancreatic cancer What the oncologist can offer for palliation Can J Gastroenterol 16 2002 121 124
14. T. Heisler, S. Towfigh, N. Simon Peptide YY augments gross inhibition by vitamin E succinate of human pancreatic cancer cell growth J Surg Res 88 2000 23 25
15. C.D. Liu, A.J. Rongione, L. Garvey Adjuvant hormonal treatment with peptide YY or its analog decreases human pancreatic carcinoma growth Am J Surg 171 1996 192 196
16. C.D. Liu, A. Balasubramaniam, R.E. Saxton Human pancreatic cancer growth is inhibited by peptide YY and BIM-43004-1 J Surg Res 58 1995 707 712