Acute and chronic effects of hormone replacement therapy on the cardiovascular system in healthy postmenopausal women

Journal of Clinical Endocrinology and Metabolism

Volumn 89, Issue 4, 2004, Pages 1618-1629

  Kirwan, Lori D ^a   MacLusky, Neil J ^d   Shapiro, Heather M ^b   Abramson, Beth L ^c   Thomas, Scott G ^a   Goodman, Jack M ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c ST MICHAEL'S HOSPITAL   (Canada)

^d NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ESTRADIOL; PLACEBO; PROGESTERONE;

ADULT; ARTICLE; BLOOD FLOW; CARDIOVASCULAR FUNCTION; CARDIOVASCULAR RISK; CARDIOVASCULAR SYSTEM; CONTROLLED STUDY; DRUG EFFECT; EXERCISE TOLERANCE; FEMALE; FLOW RATE; HEART OUTPUT; HORMONE SUBSTITUTION; HUMAN; LONG TERM CARE; NORMAL HUMAN; OXYGEN CONSUMPTION; POSTMENOPAUSE; PRIORITY JOURNAL; RANDOMIZATION; RESPIRATORY FUNCTION;

CARDIAC OUTPUT; CARDIOVASCULAR SYSTEM; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; ESTRADIOL; ESTROGEN REPLACEMENT THERAPY; EXERCISE; FEMALE; HUMANS; LEG; MIDDLE AGED; POSTMENOPAUSE; PROGESTERONE; REFERENCE VALUES; REGIONAL BLOOD FLOW; REST; STROKE VOLUME; TIME FACTORS;

EID: 1942537111     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.2003-030324     Document Type: Article

References (68)

1. Stampfer MJ, Colditz GA, Willett WC, Manson JE, Rosner B, Speizer FE, Hennekens CH 1991 Postmenopausal estrogen therapy and cardiovascular disease. Ten-year follow-up from the nurses' health study. N Engl J Med 325:756-762
2. Bush TL, Barrett-Connor E, Cowan LD 1987 Cardiovascular mortality and noncontraceptive use of estrogen in women: results from the Lipid Research Clinics Program follow-up study. Circulation 75:1102-1109
3. Grodstein F, Stampfer MJ, Manson JAE, Colditz GA, Willet WC, Rosner B, Speizer FE, Hennekens CH 1996 Postmenopausal estrogen and progestin use and the risk of cardiovascular disease. N Engl J Med 335:453-461
4. PEPI 1995 Effects of estrogen or estrogen/progestin regimens on heart disease risk factors in postmenopausal women. JAMA 273:199-208
5. Hulley S, Grady D, Bush T, Furberg C, Herrington D, Riggs B, Vittinhoff E 1998 Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. JAMA 280:605-613
6. Herrington DM, Reboussin DM, Brosnihan KB, Sharp PC, Shumaker SA, Snyder TE, Furberg CD, Kowalchuk GJ, Stuckey TD, Rogers WJ, Givens DH, Waters D 2000 Effects of estrogen replacement on the progression of coronary-artery atherosclerosis. N Engl J Med 343:522-529
7. Investigators WHI 2002 Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled trial. JAMA 288:321-333
8. MacLusky N 1996 Sex steroid receptors. In: Adasi EY, Rock JA, Rosenwaks Z, eds. Reproductive endocrinology, surgery and technology. Philadelphia: Lippincott-Raven Publishers
9. Kawano H, Motoyama T, Hirai N, Yoshimura T, Kugiyama K, Ogawa H, Okamura H, Yasue H 2001 Effect of medroxyprogesterone acetate plus estradiol on endothelium-dependent vasodilation in postmenopausal women. Am J Cardiol 87:238-240
10. Miyagawa K, Rosch J, Stanczyk F, Hermsmeyer K 1997 Medroxyprogesterone interferes with ovarian steroid protection against coronary vasospasm. Nat Med 3:324-327
11. Williams JK, Honore EK, Washburn SA, Clarkson TB 1994 Effects of hormone replacement therapy on reactivity of atherosclerotic coronary arteries in cynomolgus monkeys. J Am Coll Cardiol 24:1757-1761
12. Rosano GM, Webb CM, Chierchia S, Morgani GL, Gabraele M, Sarrel PM, de Ziegler D, Collins P 2000 Natural progesterone, but not medroxyprogesterone acetate, enhances the beneficial effect of estrogen on exercise-induced myocardial ischemia in postmenopausal women. J Am Coll Cardiol 36:2154-2159
13. Hodis HN, Mack WJ, Lobo RA, Shoupe D, Sevanian A, Mahrer PR, Selzer RH, Liu CCR, Liu CC H, Azen SP 2001 Estrogen in the prevention of atherosclerosis. A randomized, double-blind, placebo-controlled trial. Ann Intern Med 135:939-953
14. Bhavnani BR 1998 Pharmacokinetics and pharmacodynamics of conjugated equine estrogens: chemistry and metabolism. Proc Soc Exp Biol Med 217:6-16
15. Dey M, Lyttle RC, Pickar JH 2000 Recent insights into the varying activity of estrogens. Maturitas 34:S25-S33
16. Klein R 1998 The composition of Premarin. Int J Fertil 43:223
17. Mendelsohn ME 2002 Genomic and nongenomic effects of estrogen in the vasculature. Am J Cardiol 90:3F-6F
18. Ho JE, Mosca L 2002 Postmenopausal hormone replacement therapy and atherosclerosis. Curr Atheroscler Rep 4:387-395
19. Lieberman EH, Gerhard MD, Uehata AU, Walsh BW, Selwyn AP, Ganz P, Yeung AC, Creager MA 1994 Estrogen improves endothelium-dependent, flow mediated vasodilation in postmenopausal women. Ann Intern Med 121: 936-941
20. Pinto S, Virdis A, Ghiadoni L, Bernini G, Lombardo M, Petraglia F, Genazzani AR, Taddei S, Salvetti A 1997 Endogenous estrogen and acetylcholine induced vasodilation in normotensive women. Hypertension 29:268-273
21. Herrington DM, Espeland MA, Crouse 3rd JR, Robertson J, Riley WA, McBurnie MA, Burke GL 2001 Estrogen replacement and brachial artery flow-mediated vasodilation in older women. Arterioscler Thromb Vasc Biol 21:1955-1961
22. Gilligan DM, Badar DM, Panza JA, Quyyumi AA, Cannon 3rd RO 1994 Acute vascular effects of estrogen in postmenopausal women. Circulation 90:786-791
23. Gilligan DM, Quyyumi AA, Cannon 3rd RO 1994 Effects of physiological levels of estrogen on coronary vasomotor function in postmenopausal women. Circulation 89:2545-2551
24. Gilligan DM, Badar DM, Panza JA, Quyyumi AA, Cannon 3rd RO 1995 Effects of estrogen replacement therapy on peripheral vasomotor function in postmenopausal women. Am J Cardiol 75:264-268
25. Barclay JK, Stainsby WN 1985 The role of blood flow in limiting maximal metabolic rate in muscle. Med Sci Sports 7:116-119
26. Andersen P, Saltin B 1985 Maximal perfusion of skeletal muscle in man. J Physiol 366:233-249
27. 2 max in the exercise-trained human quadriceps. J Appl Physiol 86:1048-1053
28. Reading JL, Goodman JM, Plyley MJ, Foras JS, Liu PP, McLaughlin PR, Shephard RJ 1993 Vascular conductance and aerobic power in sedentary and active subjects and heart failure patients. J Appl Physiol 74:567-573
29. Martin WH, Ogawa T, Korhrt WM, Malley MT, Korte E, Kieffer PS, Schechtman KB 1991 Effects of aging, gender and physical activity on peripheral vascular function. Circulation 84:654-664
30. Snell PG, Martin WH, Buckey JC, Blomqvist CG 1987 Maximal vascular leg conductance in trained and untrained men. J Appl Physiol 62:606-610
31. Martin 3rd WH, Kohrt WM, Malley MT, Korte E, Stoltz S 1990 Exercise training enhances leg vasodilatory capacity of 65-yr-old men and women. J Appl Physiol 69:1804-1809
32. Lee M, Giardina E-G, Homma S, DiTullio MR, Sciacca RR 1997 Lack of effect of estrogen on rest and treadmill exercise in postmenopausal women without known cardiac disease. Am J Cardiol 80:793-797
33. Lindheim SR, Notelovitz M, Feldman EB, Larsen S, Khan FY 1994 The independent effects of exercise and estrogen on lipids and lipoproteins in postmenopausal women. Obstet Gynecol 83:167-172
34. Pi-Sunyer FX 2000 Obesity: criteria and classification. Proc Nutr Soc 59: 505-509
35. Durnin JV, Rahaman MM 1967 The assessment of the amount of fat in the human body from measurements of skinfold thickness. Br J Nutr 21:681-689
36. Wheeler MJ 1995 The determination of bio-available testosterone. Ann Clin Biochem 32:345-357
37. Gordon NF, Scott CB 1995 Exercise intensity prescription in cardiovascular disease. Theoretical basis for anaerobic threshold determination. J Cardiopulm Rehabil 15:193-196
38. Beaver WL, Wasserman K, Whipp BJ 1986 A new method for detecting anaerobic threshold by gas exchange. J Appl Physiol 60:2020-2027
39. Shimizu M, Myers J, Buchanan N, Walsh D, Kraemer M, McAuley P, Froelicher VF 1991 The ventilatory threshold: method, protocol, and evaluator agreement. Am Heart J 122:509-516
40. 2 tensions by rebreathing. J Appl Physiol 9:25-29
41. Jones NL 1997 Clinical exercise testing. Philadelphia: WB Saunders Co.
42. Deleted in proof.
43. 2 max among highly trained athletes. J Appl Physiol 87:1368-1372
44. Holkanson DE, Sumner DS, Strandne DE 1975 An electrically calibrated plethysmograph for direct measurement of limb blood flow. IEEE Trans Biomed Eng 22:25-29
45. Jones B, Kenward MG 1989 Design and analysis of cross-over trials. London: Chapman, Hall
46. Kenward MG, Jones B 1987 The analysis of data from 2X2 cross-over trials with baseline measures. Stat Med 6:911-926
47. Streiner DL, Norman GR 2000 Biostatistics: the bare essentials. Hamilton, Ontario Canada: BC Decker
48. Redberg RF, Nishino M, McElhinney DB, Dae MW, Botvinick EH 2000 Long-term estrogen replacement therapy is associated with improved exercise capacity in postmenopausal women without known coronary artery disease. Am Heart J 139:739-744
49. Barrett-Connor E 1991 Postmenopausal estrogen and prevention bias. Ann Intern Med 115:455-460
50. Sturgeon SR, Schairer C, Brinton LA, Pearson T, Hoover RN 1995 Evidence of a healthy estrogen user survivor effect. Epidemiology 6:227-231
51. Snabes MC, Herd AJ, Schuyler N, Dunn K, Spence DW, Young RL 1996 In normal postmenopausal women physiologic estrogen replacement therapy fails to improve exercise tolerance: a randomized double-blind, placebo-controlled, cross-over trial. Am J Obstet Gynecol 175:110-114
52. McCole SD, Brown MD, Moore GE, Zmuda JM, Cwynar JD, Hagberg JM 1999 Cardiovascular hemodynamics with increasing exercise intensities in postmenopausal women. J Appl Physiol 87:2334-2340
53. 2 relationships during submaximal cycle ergometry. J Appl Physiol 84:599-605
54. Vita JA, Keaney Jr JF 2001 Hormone replacement therapy and endothelial function: the exception that proves the rule? Arterioscler Thromb Vasc Biol 21:1867-1869
55. Williams JK, Adams M, Klopfenstein S 1990 Estrogen modulates responses of atherosclerotic coronary arteries. Circulation 81:1680-1687
56. Williams JK, Adams MR, Herrington DM, Clarkson TB 1992 Short term administration of estrogen and vascular responses of atherosclerotic coronary arteries. J Am Coll Cardiol 20:452-457
57. Reis S, Gloth ST, Blumenthal RS, Resar JR, Zacur HA, Gerstenblith G, Brinker JA 1993 Ethinyl estradiol acutely attenuates abnormal coronary vasomotor responses to acetylcholine in postmenopausal women. Circulation 89:52-60
58. Collins P, Shay J, Jiang C, Moss J 1994 Nitric oxide accounts for dose-dependent estrogen-mediated coronary relaxation after acute estrogen withdrawal. Circulation 90:1964-1968
59. Volterrani M, Rosano G, Coats A, Beale C, Collins P 1995 Estrogen acutely increases peripheral blood flow in postmenopausal women. Am J Med 99: 119-122
60. Herrington DM, Espeland MA, Crouse 3rd JR, Robertson J, Riley WA, McBurnie MA, Burke GL 2001 Estrogen replacement and brachial artery flow-mediated vasodilation in older women. Arterioscler Thromb Vasc Biol 21:1955-1961
61. Peterson LR, Courtois M, Peterson LF, Peterson MR, Davila-Roman VG, Spina RJ, Barzilai B 2000 Estrogen increases hyperemic microvascular blood flow velocity in postmenopausal women. J Gerontol A Biol Sci Med Sci 55: M174-M179
62. Gerhard M, Walsh BW, Tawakol A, Haley EA, Creager SJ, Seely EW, Ganz P, Creager MA 1998 Estradiol therapy combined with progesterone and endothelium-dependent vasodilation in postmenopausal women. Circulation 98:1158-1163
63. Deleted in proof.
64. Wakatsuki A, Okatani Y, Ikenoue N, Fukaya T 2001 Effect of medroxyprogesterone acetate on endothelium-dependent vasodilation in postmenopausal women receiving estrogen. Circulation 104:1773-1778
65. Goodman JM, Pallandi DV, Reading JR, Plyley MJ, Liu PP, Kavanagh T 1999 Central and peripheral adaptations after 12 weeks of exercise training in post-coronary artery bypass surgery patients. J Cardiopulm Rehabil 19: 144-149
66. Kirwan LD, Mertens DJ, Kavanagh T, Thomas SG, Goodman JM 2003 Exercise training in older women with heart disease: influence of hormone replacement therapy. Med Sci Sports Exerc 35:185-192
67. Green JS, Crouse SF, Rohack JJ 1998 Peak exercise hemodynamics in exercising postmenopausal women taking versus not taking supplemental estrogen. Med Sci Sports Exerc 30:158-164
68. Stachenfeld NS, DiPietro L, Palter SF, Nadel ER 1998 Estrogen influences osmotic secretion of AVP and body water balance in postmenopausal women. Am J Physiol 274:R187-R195