Screening of Thrombin Inhibitors from Medicinal and Wild Plants

Korean Journal of Pharmacognosy

Volumn 35, Issue 1, 2004, Pages 52-61

  Sohn, Ho Yong ^a   Kwon, Yun Sook ^a   Kim, Young Sook ^a   Kwon, Ha Young ^a   Kwon, Gi Seok ^a   Kim, Kyung Jae ^b   Kwon, Chong Suk ^a   Son, Kun Ho ^a  

^a Andong National University   (South Korea)

^b Daepyung Co Ltd   (South Korea)

Author keywords

Activated Partial Thromboplastin Time (aPTT); Medicinal and wild plants; Thrombin time (TT); Thrombosis

Indexed keywords

CHYMOTRYPSIN; METHANOL DERIVATIVE; PAPAIN; PEPSIN A; PLANT EXTRACT; PROTEINASE; THROMBIN; THROMBIN INHIBITOR; TRYPSIN;

AMOMUM; ANTICOAGULATION; ARTICLE; DRUG ACTIVITY; DRUG SCREENING; ENZYME INHIBITION; EPHEDRA SINICA; FIBRINOLYSIS; GINKGO BILOBA; HUMAN; MAGNOLIACEAE; MEDICINAL PLANT; NONHUMAN; PARTIAL THROMBOPLASTIN TIME; REYNOUTRIA ELLIPTICA; THERMOSTABILITY; THROMBIN TIME;

EID: 1942536047     PISSN: 02533073     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Korea National Statistical Office. (2000). A study on causes of death for 1999.
2. Lee, S.-S., Kim, S.-M., Park U.-Y., Kim, H.-Y., and Shin, I.-S. (2002). Studies on proteolytic and fibrinolytic activity of Bacillus subtilis JM-3 isolated from anchovy sauce. Korean J. Food Sci. Technol. 34: 283-289.
3. Yun, Y.-P., Kang, W.-S., and Lee, M.-Y. (1996). The antithrombotic effects of green tea catechins. J. Fd Hyg. Safety, 11: 77-82.
4. Yun-Choi, H. S., Chung, K. S., Kim, M. H., and Oh, J. H. (1995). Antithrombotic effects of some traditional plant medicines. Kor. J. Pharmacogn. 26: 154-158.
5. Weitz, J. I. and Crowther, M. (2002). Direct thrombin inhibitors. Thrombosis Research, 106: 275-284.
6. Butenas, S. and Mann, K. G. (2002). Blood coagulation. Biochemisrty (Moscow), 67: 3-12.
7. Hsieh, K.-H. (1997). Thrombin interaction with fibrin polymerization sites. Thrombosis Research, 86: 301-316.
8. Hahn, B. S., Wu, S., Kim, S.-W., and Kim, Y. S. (1999). Evaluation of anticoagulant and fibrinolytic activities from crude extracts of insects. Kor. J. Pharmacogn. 30: 409-412.
9. Cattaneo, F., Trento, F., Pescador, R., Porta, R., and Furro, L. (2002). Pharmacodynamics of the anticoagulant activity (APTT) of an algal polysaccharide. Thrombosis Research, 105: 455-457.
10. Gwak, H.-S. and Chun, I. K. (2000). Performulation study of aspalatone, a new antithrombotic agent. The J. Appl. Pharmacol. 8: 332-337.
11. Molina, V., Arruzazabala, M. L., and Mas, C. R. (2003). Synergistic effect of D-003 and aspirain on experimental thrombosis models. Prostag. Leukotr. Ess. 68: 305-310.
12. Paik, Y.-S., Song, J.-K., Yoon, C. H., Chung, K. S., and Yun-Choi, H. S. (1995). Anti-platelet and anti-thrombotic effects of Gastrodia elata. Kor. J. Pharmacogn. 26: 385-389.
13. Lee, T. B. (1993). Illustrated flora of Korea, Hwang Moon Sa, Seoul.
14. Lee, H. J., Kim, J. S., Heo, G.-Y., Lee, K.-B., Rhee, I.-K., and Song, K.-S. (1999). Inhibitory activities of Basidiomycetes on prolyl endopeptidase, acetylcholine esterase and coagulation. J. Korean Soc. Agri. Chem. Biotechnol. 42: 336-343.
15. Astrup, T. and Mullertz, S. (1952). The fibrin plate method for estimating fibrinolytic activity. Archs. Biochem. Biophys. 40: 346-350.
16. Yi, D.-H. and Seu, J.-H. (1982). Trypsin inhibitor from Streptomyces sp. (Part 1) Isolation of microorganism and purification of the inhibitor. Kor. J. Appl. Microbiol. Bioeng. 10: 275-281.