The "ascorbate" effect on 2,3-DPG is known to be due to Oxalate [2]

Vox Sanguinis

Volumn 86, Issue 3, 2004, Pages 199-

  Beutler, E ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,3 DIPHOSPHOGLYCERIC ACID; ASCORBIC ACID; ASCORBIC ACID 2 PHOSPHATE; DEHYDROASCORBIC ACID; OXALIC ACID; PYRUVIC ACID;

BLOOD STORAGE; CELL LEVEL; ERYTHROCYTE; HUMAN; LETTER; PRIORITY JOURNAL;

2,3-DIPHOSPHOGLYCERATE; ADENINE; ARTIFACTS; ASCORBIC ACID; BLOOD PRESERVATION; CITRATES; DRUG CONTAMINATION; ENZYME INHIBITORS; ERYTHROCYTES; GLUCOSE; HUMANS; HYDROGEN-ION CONCENTRATION; MANNITOL; NIACIN; OXALIC ACID; PHOSPHATES; PYRUVATE KINASE; SODIUM CHLORIDE; SOLUTIONS;

EID: 1942531254     PISSN: 00429007     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.0042-9007.2004.00415.x     Document Type: Letter

References (6)

1. Kurup PA, Arun P, Gayathri CR, Dhanya CR, Indu AR: Modified formulation of CPDA for storage of whole blood and of SAGM for storage of red blood cells, to maintain the concentration of 2,3-diphosphoglycerate. Vox Sang 2003; 85:253-261
2. Carmen RA, Sohmer PR, Leng BS, Moore GL, Nelson EJ, Simon TL, Myhre BA, Marcus CS, Moroff G, Lewis LM, Chong C: Five-week red cell storage with preservation of 2,3 DPG. Transfusion 1988; 28:157-161.
3. Wood L, Beutler E: The effect of ascorbic acid on the 2,3-diphosphoglycerate (2,3-DPG) level of stored blood. Clin Res 1972; 20:186
4. Wood LA, Beutler E: The effect of ascorbate on the maintenance of 2,3-diphosphoglycerate (2,3-DPG) in stored red cells. Br J Haematol 1973; 25:611-618
5. Kandler R, Grode G, Symbol R, Hickey G: Oxalate is the active component that produces increased 2,3-DPG in ascorbate stored red cells. Transfusion 1986; 26:563
6. Beutler E, Forman L, West C: Effect of oxalate and malonate on red cell metabolism. Blood 1987; 70:1389-1393