Is keeping cool still hot? An update on hypothermia in brain injury

Current Opinion in Critical Care

Volumn 10, Issue 2, 2004, Pages 116-119

  Clifton, Guy L ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

Brain injury; Hypothermia; Intracranial pressure; Neuroprotectant

Indexed keywords

BARBITURIC ACID DERIVATIVE; MANNITOL;

BRAIN INJURY; CLINICAL TRIAL; COOLING; DISABILITY; HEART ARREST; HUMAN; INDUCED HYPOTHERMIA; INTRACRANIAL HYPERTENSION; INTRACRANIAL PRESSURE; MORTALITY; NEUROPROTECTION; PERSISTENT VEGETATIVE STATE; REVIEW; TREATMENT OUTCOME;

BRAIN INJURIES; HEART ARREST; HUMANS; HYPOTHERMIA, INDUCED; UNITED STATES;

EID: 1942519292     PISSN: 10705295     EISSN: None     Source Type: Journal    
DOI: 10.1097/00075198-200404000-00007     Document Type: Review

References (26)

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12. Clifton GL, Miller E, Choi SC, et al.: Lack of effect of induction of hypothermia after acute brain injury. N Engl J Med 2001, 344:556-563. The results of multicenter clinical trial with 392 patients testing hypothermia as a neuroprotectant are reported.
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21. Henderson WR, Dhingra VK, Chittock DR, et al.: Hypothermia in the management of traumatic brain injury. A systematic review and meta-analysis. Intensive Care Med 2003, 29:1637-1644. An analysis of pooled data from 748 patients in eight randomized, controlled trials finds the lack of strong evidence of hypothermia benefit.
22. McIntire LA, Fergusson DA, Hebert PC, et al.: Prolonged therapeutic hypothermia after traumatic brain injury in adults. JAMA 2003, 289:2992-2999. This article reviews all randomized, controlled trials of hypothermia induced for at least 24 hours with demographic and clinical data.
23. Shiozaki T, Hayakata T, Taneda M, et al.: A multicenter prospective randomized controlled trial of the efficacy of mild hypothermia for severely head injured patients with low intracranial pressure. J Neurosurg 2001, 94:50-54. This study concludes that hypothermia has no advantage over normothermia in patients with head injury with low intracranial pressure.
24. Bernard SA, Gray TW, Buist MD, et al.: Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia. N Engl J Med 2002, 346:557-563. This study of 77 patients who remained unconscious after cardiac arrest reports improved outcomes with early hypothermia induction.
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