Early structural effects of oestrogen on pudendal nerve regeneration in the rat

BJU International

Volumn 93, Issue 6, 2004, Pages 870-878

  Kane, D D ^a   Kerns, J M ^a   Lin, D L ^b,c   Damaser, M S ^b,c  

^a RUSH UNIVERSITY   (United States)

^b HINES VA HOSPITAL   (United States)

^c LOYOLA UNIVERSITY CHICAGO   (United States)

Author keywords

External urethral sphincter; Nerve injury; Oestrogen; Pudendal nerve; Ultrastructure; Urinary incontinence

Indexed keywords

ESTRADIOL; MYELIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLADDER SPHINCTER; CONTROLLED STUDY; DRUG CAPSULE; DRUG EFFECT; DRUG IMPLANT; ELECTRON MICROSCOPY; ENDONEURIUM; FEMALE; MICROSCOPY; MYELINATED NERVE; NERVE CRUSH; NERVE DEGENERATION; NERVE FIBER; NERVE REGENERATION; NONHUMAN; OVARIECTOMY; PRIORITY JOURNAL; PUDENDAL NERVE; RAT; ULTRASTRUCTURE; URETHRA;

ANIMALS; AXONS; ESTROGENS; FEMALE; MICROSCOPY, ELECTRON; NERVE CRUSH; NERVE FIBERS, MYELINATED; NERVE REGENERATION; PERIPHERAL NERVES; RATS; RATS, SPRAGUE-DAWLEY; URETHRA;

EID: 1942509680     PISSN: 14644096     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1464-410X.2003.04792.x     Document Type: Article

References (53)

1. MacLennan AH, Taylor AW, Wilson DH, Wilson D. The prevalence of pelvic floor disorders and their relationship to gender, age, parity and mode of delivery. Br J Obstet Gynaecol 2000; 107: 1460-70
2. Turan C, Zorlu CG, Ekin M, Hancerliogullari N, Saracoglu F. Urinary incontinence in women of reproductive age. Gynecol Obstet Invest 1996; 41: 132-4
3. Thomas TM, Plymat KR, Blannin J, Meade TW. Prevalence of urinary incontinence. BMJ 1980; 281: 1243-5
4. Snooks SJ, Swash M, Henry MM, Setchell M. Risk factors in childbirth causing damage to the pelvic floor innervation. Int J Colorectal Dis 1986; 1: 20-4
5. de Groat WC. Anatomy and physiology of the lower urinary tract. Urol Clin North Am 1993; 20: 383-401
6. Tetzschner T, Sorensen M, Jonsson L, Lose G, Christiansen J. Delivery and pudendal nerve function. Acta Obstet Gynecol Scand 1997; 76: 324-31
7. Mäkinen JI, Pitkänen YA, Salmi TA, Grönroos M, Rinne R, Paakkari I. Transdermal estrogen for female stress urinary incontinence in postmenopause. Maturitas 1995; 22: 233-8
8. Jones KJ, Brown TJ, Damaser MS. Neuroprotective effects of gonadal steroids on regenerating peripheral motoneurons. Brain Res Rev 2001; 37: 372-82
9. Garcia-Segura LM, Azcoitia I, DonCarlos LL. Neuroprotection by estradiol. Prog Neurobiol 2001; 63: 29-60
10. Kane DD, Shott S, Hughes WF, Kerns JM. Motor pudendal nerve characterization in the female rat. Anat Rec 2002; 266: 21-9
11. Kerns JM, Damaser MS, Kane JM et al. Effects of pudendal nerve injury in the female rat. Neurourol Urodynam 2000; 19: 53-69
12. Damaser MS, Ferguson CL, Broxton-King C, Kim FJ, Kerns JM. Functional and neuroanatomical effects of vaginal distension and pudendal nerve crush in the female rat. J Urol 2003; 170: 1027-31
13. McKenna KE, Nadelhaft I. The pudendopudendo reflex in male and female rats. J Auton Nerv Syst 1989; 27: 67-77
14. McKenna KE, Nadelhaft I. The organization of the pudendal nerve in the male and female rat. J Comp Neurol 1986; 248: 532-49
15. Pacheco P, Martinez-Gomez M, Whipple B, Beyer C, Komisaruk BR. Somato-motor components of the pelvic and pudendal nerves of the female rat. Brain Res 1989; 490: 85-94
16. Ueyama T, Arakawa H, Mizuno N. Central distribution of efferent and afferent components of the pudendal nerve in the rat. Anat Embryol 1987; 177: 37-49
17. Pascual JI, Insausti R, Gonzalo LM. Pudendal nerve topography in the rat spinal cord projections studied with the axonal tracer wheat germ agglutinin conjugated-horseradish peroxidase. J Urol 1992; 147: 718-22
18. Pascual JI, Insausti R, Gonzalo LM. The pelvic innervation in the rat, different spinal origin and projections in Sprague-Dawley and Wistar rats. Brain Res 1989; 480: 397-402
19. Tanzer L, Jones KJ. Gonadal steroid regulation of hamster facial nerve regeneration - effects of dihydrotestosterone and estradiol. Exper Neurol 1997; 146: 258-64
20. Dubal DB, Kashon M, Pettigrew LC et al. Estradiol protects against ischemic injury. J Cereb Blood Flow Metab 1998; 18: 1253-8
21. Kerns JM, Fakhouri AJ, Weinrib HP, Freeman JA. Electrical stimulation of nerve regeneration in the rat: the early effects evaluated by a vibrating probe and electron microscopy. Neurosci 1991; 40: 93-107
22. Pandit M, Delancey JOL, Ashton-Miller JA, Tyengar J, Blaivas M, Perucchini D. Quantification of intramuscular nerves within the female striated urogenital sphincter muscle. Obstet Gynecol 2000; 95: 797-800
23. Allen RE, Hosker GL, Smith ARB, Warrell DW. Pelvic floor damage and childbirth: a neurophysiological study. Br J Obstet Gynaecol 1990; 97: 770-9
24. Morley R, Cumming J, Weller R. Morphology and neuropathology of the pelvic floor in patients with stress incontinence. Int Urogynecol J 1996; 7: 3-12
25. Klutke JJ, Bergman A. Hormonal influence on the urinary tract. Urol Clin North Am 1995; 22: 629-39
26. Salmon UJ, Walter RI, Geist SH. The use of estrogens in the treatment of dysuria and incontinence in postmenopausal women. Am J Obstet Gynecol 1941; 42: 845-51
27. Kinn A-C, Lindskog M. Estrogens and phenylpropanolamine in combination for stress urinary incontinence in postmenopausal women. Urology 1988; 32: 273-80
28. Grady D, Brown J, Vittinghoff E, Applegate W, Varner E, Synder T. Postmenopausal hormones and incontinence: the heart and estrogen/progestin replacement study. Obstet Gynecol 2001; 97: 116-20
29. Bhatia NN, Bergman A, Karram MM. Effects of estrogen on urethral function in women with urinary incontinence. Obstet Gynecol 1989; 160: 176-81
30. Bergman A, Karram MM, Bhatia NN. Changes in urethral cytology following estrogen administration. Gynecol Obstet Invest 1990; 29: 211-3
31. Black MM, Shuster S, Bottoms E. Osteoporosis, skin collagen, androgen. BMJ 1970; 26: 773-4
32. Iosif CS, Batra S, Ek A, Åstedt B. Estrogen receptors in the human female lower urinary tract. Am J Obstet Gynecol 1981; 141: 817-20
33. Batra SC, Iosif CS. Female urethra: a target for estrogen action. J Urol 1983; 129: 418-20
34. Ishiko O, Hirai K, Sumi T, Tatsuta I, Ogita S. Hormone replacement therapy plus pelvic floor muscle exercise for postmenopausal stress incontinence. A randomized, controlled trial. J Repro Med 2001; 46: 213-20
35. Fantl JA, Cardozo L, McClish DK. Estrogen therapy in the management of urinary incontinence in postmenopausal women - a meta-analysis - first report of the hormones and urogenital therapy committee. Obstet Gynecol 1994; 83: 12-8
36. Cardozo L. Role of estrogens in the treatment of female urinary incontinence. J Am Geriatr Soc 1990; 38: 326-8
37. Sakamoto K, Smith GM, Storer PD, Jones KJ, Damaser MS. Neuroregeneration and voiding behavior patterns after pudendal nerve crush in female rats. Neurourol Urodynam 2000; 19: 311-21
38. Zoubina EV, Smith PG. Expression of estrogen receptors α and β by sympathetic ganglion neurons projecting to the proximal urethra of female rats. J Urol 2003; 169: 382-5
39. Zoubina EV, Mize AL, Alper RH, Smith PG. Acute and chronic estrogen supplementation decreases uterine sympathetic innervation in ovariectomized adult virgin rats. Histol Histopathol 2001; 16: 989-96
40. Lundborg G. Nerve regeneration. In Nerve Injury and Repair. New York: Churchill Livingstone, 1988: 149-95
41. Scherer SS, Easter SS. Degenerative and regenerative changes in the trochlear nerve of goldfish. J Neurocytol 1984; 13: 519-65
42. Kerns J. Postnatal differentiation of the rat trochlear nerve. J Comp Neurol 1980; 189: 291-306
43. Mackinnon SE, Dellon AL. Surgery of the Peripheral Nerve. New York: Thieme Medical Publishers, 1988: 16-24
44. Lieberman AR. The axon reaction. A review of the principal features of perikaryal responses to axon injury. Int Rev Neurobiol 1971; 14: 49-125
45. Dubal DB, Zhu H, Yu J et al. Estrogen receptor α, not β, is a critical link in estradiol-mediated protection against brain injury. Proc Natl Acad Sci USA 2001; 98: 1952-7
46. Wise PM. Estrogens and neuroprotection. Trends Endo Metab 2002; 13: 229-30
47. Wise PM, Dubal DB, Wilson ME, Rau SW, Bottner M. Minireview: Neuroprotective effects of estrogen - new insights into mechanisms of action. Endocrinol 2001; 142: 969-73
48. Wise PM, Dubal DB, Wilson ME, Rau SW, Bottner M, Rosewell KL. Estradiol is a protective factor in the adult and aging brain: understanding of mechanisms derived from in vivo and in vitro studies. Brain Res 2001; 37: 313-9
49. Wise PM, Smith MJ, Dubal DB et al. Neuroendocrine modulation and repercussions of female reproductive aging. Recent Prog Hormone Res 2002; 57: 235-56
50. Tanzer L, Sengelaub DR, Jones KJ. Estrogen receptor expression in the facial nucleus of adult hamsters: Does axotomy recapitulate development? J Neurobiol 1999; 39: 438-46
51. Thornton GM, Hughes WF, Damaser MS, Kerns JM. Neuromuscular junctions in the rat external urethral sphincter. Soc Neurosci Abstract 2001; 27: 2231
52. Gabella G. Structure of the intramural nerves of the rat bladder. J Neurocytol 1999; 28: 615-37
53. Brushart TM. Motor axons preferentially reinnervate motor pathways. J Neurosci 1993; 13: 2730-8