Effect of drug release rate on therapeutic outcomes: Formulation dependence of gastrointestinal toxicity of diclofenac in the rat

Inflammopharmacology

Volumn 12, Issue 1, 2004, Pages 69-80

  Khazaeinia, Tahereh ^a,b   Jamali, Fakhreddin ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b Huntingdon Life Sciences New Jersey   (United States)

Author keywords

Diclofenac; Formulation; Gastrointestinal permeability; Gastrointestinal toxicity; NSAID

Indexed keywords

BIOCHEMICAL MARKER; DICLOFENAC; EDETIC ACID; NONSTEROID ANTIINFLAMMATORY AGENT; SUCROSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; BILIARY EXCRETION; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; DRUG EFFECT; DRUG FORMULATION; DRUG RELEASE; EXPOSURE; GASTROINTESTINAL ABSORPTION; GASTROINTESTINAL MUCOSA; GASTROINTESTINAL TOXICITY; MALE; NONHUMAN; OUTCOMES RESEARCH; PRIORITY JOURNAL; RAT; SUSTAINED RELEASE PREPARATION; TREATMENT OUTCOME;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CHEMISTRY, PHARMACEUTICAL; DELAYED-ACTION PREPARATIONS; DICLOFENAC; DIGESTIVE SYSTEM; MALE; PERMEABILITY; RATS; RATS, SPRAGUE-DAWLEY; SOLUBILITY;

EID: 1942487882     PISSN: 09254692     EISSN: None     Source Type: Journal    
DOI: 10.1163/156856004773121383     Document Type: Article

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