Are cataract and iris atrophy toxic complications of medical treatment of acanthamoeba keratitis?

Acta Ophthalmologica Scandinavica

Volumn 82, Issue 2, 2004, Pages 228-231

  Ehlers, Niels ^a   Hjortdal, Jasper ^a  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Acanthamoeba; Chlorhexidine; Grafting; Keratitis; Polyhexamethylene biguanide; Toxicity

Indexed keywords

ACETAZOLAMIDE; ACICLOVIR; ANTIBIOTIC AGENT; ANTIGLAUCOMA AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CHLORHEXIDINE; DEXAMETHASONE; FLUCONAZOLE; GENTAMICIN; POLY(HEXAMETHYLENEBIGUANIDE); PREDNISOLONE PIVALATE; PROPAMIDINE ISETHIONATE; SCOPOLAMINE; STEROID;

ACANTHAMOEBA KERATITIS; ADULT; ARTICLE; CASE REPORT; CATARACT; CATARACT EXTRACTION; CORNEA PERFORATION; CORNEA ULCER; DISEASE COURSE; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; INTRAOCULAR PRESSURE ABNORMALITY; IRIS ATROPHY; KERATITIS; LENS IMPLANTATION; PENETRATING KERATOPLASTY; PRIORITY JOURNAL; SECONDARY GLAUCOMA; TRABECULECTOMY; TREATMENT OUTCOME;

ACANTHAMOEBA KERATITIS; ANTIPROTOZOAL AGENTS; ATROPHY; BENZAMIDINES; CATARACT; CATARACT EXTRACTION; CHLORHEXIDINE; DRUG THERAPY, COMBINATION; FEMALE; HUMANS; IRIS; KERATOPLASTY, PENETRATING; LENS IMPLANTATION, INTRAOCULAR; MIDDLE AGED; VISUAL ACUITY;

EID: 1942484429     PISSN: 13953907     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0420.2004.00237.x     Document Type: Article

References (16)

1. Auran JD, Starr MB & Jakobiec FA (1987): Acanthamoeba keratitis: a review of the literature. Cornea 6: 2-26.
2. Garner A (1993): Pathogenesis of acanthamoebic keratitis: hypothesis based on a histological analysis of 30 cases. Br J Ophthalmol 77: 366-370.
3. Hay J, Kirkness CM, Seal DV & Wright P (1994): Drug resistance and acanthamoeba keratitis: the quest for alternative antiprotozoal chemotherapy. Eye 8: 555-563.
4. Illingworth CD & Cook SD (1998): Acanthamoeba keratitis. Surv Ophthalmol 42: 493-506.
5. Ishibashi Y, Matsumoto Y, Kabata T, Watanabe R, Hommura S, Yasuraoka K & Ishii K (1990): Oral itraconazole and topical miconazole with debridement for acanthamoeba keratitis. Am J Ophthalmol 109: 121-126.
6. Johns KJ, Head S & O'Day DM (1988): Corneal toxicity of propamidine. Arch Ophthalmol 106: 68-69.
7. Jones DB, Visvesvara GS & Robinson NM (1975): Acanthamoeba polyphaga keratitis and acanthamoeba uveitis associated with fatal meningoencephalitis. Trans Ophthalmol Soc UK 95: 221-232.
8. Larkin DFP, Kilvington S & Dart JKG (1992): Treatment of acanthamoeba keratitis with polyhexamethylene biguanide. Ophthalmology 99: 185-191.
9. Lee GA, Gray TB, Dart JKG, Pavesio CE, Ficker LA, Larkin FP & Matheson MM (2002): Acanthamoeba sclerokeratitis. Treatment with systemic immunosuppression. Ophthalmology 109: 1178-1182.
10. Moore MB, McCulley JP, Luckenbach M, Gelender H, Newton C, McDonald MB & Visvesvara GS (1985): Acanthamoeba keratitis associated with soft contact lenses. Am J Ophthalmol 100: 396-403.
11. Murthy S, Hawksworth NR & Cree I (2002): Progressive ulcerative keratitis related to the use of topical chlorhexidine gluconate (0.02%). Cornea 21: 237-239.
12. Narington J, Watson PG, Playfair TJ et al. (1974): Amoebic infection of the eye. Lancet 2: 1537-1540.
13. Park HP, Palay DA, Daya SM, Stulting RD, Krachmer JH & Holland JH (1997): The role of topical corticoidsteroids in the management of acanthamoeba keratitis. Cornea 16: 277-283.
14. van Rij G, Beekhuis WH, Eggink CA, Geerards AJ, Remeijer L & Pels EL (1995): Toxic kerato- pathy due to accidental use of chlorhexidine, cetrimide and cialit. Doc Ophthalmol 90: 7-14.
15. Seal D, Hay D, Kirkness C, Morrell A, Booth A, Tullo A, Ridgwas A & Armstrong M (1996): Successful medical therapy of acanthamoeba keratitis with topical chlorhexidine and propamidine. Eye 10: 413-421.
16. Wright P, Warhurst D & Jones BR (1985): Acanthamoeba keratitis successfully treated medically. Br J Ophthalmol 69: 778-782.