Gallbladder volume as a biomarker for the motilin effect in healthy volunteers and patients with functional dyspepsia

Alimentary Pharmacology and Therapeutics

Volumn 19, Issue 7, 2004, Pages 797-804

  Kamerling, I M C ^a   Van Haarst, A D ^a   De Kam, M L ^a   Cohen, A F ^a   Masclee, A A M ^b   Burggraaf, J ^a  

^a CENTRE FOR HUMAN DRUG RESEARCH   (Netherlands)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; MOTILIN;

ADULT; ANALYSIS OF VARIANCE; ARTICLE; CENTRAL NERVOUS SYSTEM; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; DYSPEPSIA; ECHOGRAPHY; FEMALE; GALLBLADDER; HUMAN; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; VOLUNTEER;

ADOLESCENT; ADULT; ANALYSIS OF VARIANCE; BIOLOGICAL MARKERS; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; DYSPEPSIA; FEMALE; GALLBLADDER; GASTROINTESTINAL AGENTS; HUMANS; MALE; MIDDLE AGED; MOTILIN; RETROSPECTIVE STUDIES;

EID: 1942470128     PISSN: 02692813     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2036.2004.01905.x     Document Type: Article

References (31)

1. Polak JM, Pearse AG, Heath CM. Complete identification of endocrine cells in the gastrointestinal tract using semithinthin sections to identify motilin cells in human and animal intestine. Gut 1975; 16: 225-9.
2. Peeters TL, Vantrappen G, Janssens J. Fasting plasma motilin levels are related to the interdigestive motility complex. Gastroenterology 1980; 79: 716-9.
3. Kamerling IM, Van Haarst AD, Burggraaf J, et al. Exogenous motilin affects postprandial proximal gastric motor function and visceral sensation. Dig Dis Sci 2002; 47: 1732-6.
4. Malagelada JR. Gastrointestinal motor disturbances in functional dyspepsia. Scand J Gastroenterol Suppl 1991; 182: 29-32.
5. Tack J, Piessevaux H, Coulie B, Caenepeel P, Janssens J. Role of impaired gastric accommodation to a meal in functional dyspepsia [see comments]. Gastroenterology 1998; 115: 1346-52.
6. Stanghellini V, Tosetti C, Paternico A, et al. Risk indicators of delayed gastric emptying of solids in patients with functional dyspepsia. Gastroenterology 1996; 110: 1036-42.
7. Gorard DA, Farthing MJ. Intestinal motor function in irritable bowel syndrome. Dig Dis 1994; 12: 72-84.
8. Kellow JE, Phillips SF. Altered small bowel motility in irritable bowel syndrome is correlated with symptoms. Gastroenterology 1987; 92: 1885-93.
9. Fukudo S, Suzuki J. Colonic motility, autonomic function, and gastrointestinal hormones under psychological stress in irritable bowel syndrome. Tohoku J Exp Med 1987; 151: 373-85.
10. Sjölund K, Ekman R. Are gut peptides responsible for the irritable bowel syndrome (IBS)? Scand J Gastroenterol Suppl 1987; 130: 15-20.
11. Simren M, Abrahamsson H, Bjornsson ES. An exaggerated sensory component of the gastrocolonic response in patients with irritable bowel syndrome. Gut 2001; 48: 20-7.
12. Tack J. Georges Brohee Prize 1994. Motilin and the enteric nervous system in the control of interdigestive and postprandial gastric motility. Acta Gastroenterol Belg 1995; 58: 21-30.
13. Talley NJ. Review article: functional dyspepsia - should treatment be targeted on disturbed physiology? Aliment Pharmacol Ther 1995; 9: 107-15.
14. Nilsson BI, Svenberg T, Tollstrøm T, Hellstrøm PM, Samuelson K, Schnell PO. Relationship between interdigestive gallbladder emptying, plasma motilin and migrating motor complex in man. Acta Physiol Scand 1990; 139: 55-61.
15. Luiking YC, Peeters TL, Stolk MF, et al. Motilin induces gall bladder emptying and antral contractions in the fasted state in humans. Gut 1998; 42: 830-5.
16. Misra SP, Dwivedi M, Mital M, Misra V. Gallbladder dynamics in patients with irritable bowel syndrome and essential dyspepsia. J Clin Gastroenterol 1991; 13: 65-8.
17. Marzio L, DiFelice F, Laico MG, Imbimbo B, Lapenna D, Cuccurullo F. Gallbladder hypokinesia and normal gastric emptying of liquids in patients with dyspeptic symptoms. A double-blind placebo-controlled clinical trial with cisapride. Dig Dis Sci 1992; 37: 262-7.
18. Marzio L, Falcucci M, Ciccaglione AF, et al. Relationship between gastric and gallbladder emptying and refilling in normal subjects and patients with H. pylori-positive and -negative idiopathic dyspepsia and correlation with symptoms. Dig Dis Sci 1996; 41: 26-31.
19. Kamerling IM, Van Haarst AD, Burggraaf J, et al. Dose-related effects of motilin on proximal gastrointestinal motility. Aliment Pharmacol Ther 2002; 16: 129-35.
20. de Visser SJPJ, van der Post JP, Pieters MS, Cohen AF, Van Gerven JM. Biomarkers for the effects of antipsychotic drugs in healthy volunteers. Br J Clin Pharmacol 2001; 51: 119-32.
21. Talley NJ, Stanghellini V, Heading RC, Koch KL, Malagelada JR, Tytgat GN. Functional gastroduodenal disorders. Gut 1999; 45: 1137-42.
22. Stolk MF, van Erpecum KJ, van Berge Henegouwen GP, Kesselring OF, Hopman WP. Gallbladder volume and contraction measured by sum-of-cylinders method compared with ellipsoid and area-length methods. Acta Radiol 1990; 31: 591-6.
23. Sjölund K, Ekman R, Akre F, Lindner P. Motilin in chronic idiopathic constipation. Scand J Gastroenterol 1986; 21: 914-8.
24. Catnach SM, Ballinger AB, Law PA, Nellans H, Fairclough PD. Dose-dependent stimulation of gallbladder contraction by intravenous erythromycin in man. Aliment Pharmacol Ther 1993; 7: 55-9.
25. Fiorucci S, Bosso R, Morelli A. Erythromycin stimulates gallbladder emptying and motilin release by atropine-sensitive pathways. Dig Dis Sci 1992; 37: 1678-84.
26. Masclee AA, Ledeboer ML, Gielkens HG, van der Kleij FG, Jebbink MC, Lamers CB. Effect of erythromycin on gallbladder emptying in patients with antrectomy or truncal vagotomy. Am J Gastroenterol 1995; 90: 973-7.
27. Svenberg T, Nilsson I, Samuelson K, Welbourn RD. Studies on the causal relationship between gallbladder emptying and motilin release in man. Acta Chir Scand Suppl 1984; 520: 59-61.
28. Shaffer EA. Review article: control of gallbladder motor function. Aliment Pharmacol Ther 2000; 14(Suppl. 2): 2.
29. Suzuki T, Takahashi I, Itoh Z. Motilin and gallbladder: new dimensions in gastrointestinal physiology. Peptides 1981; 2(Suppl. 2): 229-33.
30. Jebbink MC, Masclee AA, van der Kleij FG, et al. Effect of loxiglumide and atropine on erythromycin-induced reduction in gallbladder volume in human subjects. Hepatology 1992; 16: 937-42.
31. Stolk MF, van Erpecum KJ, Smout AJ, et al. Motor cycles with phase III in antrum are associated with high motilin levels and prolonged gallbladder emptying. Am J Physiol 1993; 264: 596-600.