First trimester screening for trisomy 21: Do the parameters used detect more pathologies than just Down syndrome?

European Journal of Obstetrics and Gynecology and Reproductive Biology

Volumn 114, Issue 1, 2004, Pages 35-38

  Kabili, Genc ^a   Stricker, Reto ^b   Stricker, René ^b   Extermann, Philippe ^b   Bischof, Paul ^a  

^a UNIVERSITY OF GENEVA   (Switzerland)

^b Dianalabs Medical Laboratory   (Switzerland)

Author keywords

Free hCG; Nuchal translucency; PAPP A; Pregnancy complications; Prospective markers; Trisomy 21 screening

Indexed keywords

CHORIONIC GONADOTROPIN BETA SUBUNIT; PREGNANCY ASSOCIATED PLASMA PROTEIN A;

ABORTION; ADULT; ARTICLE; DIAGNOSTIC ACCURACY; DOWN SYNDROME; FEMALE; FETUS ECHOGRAPHY; FIRST TRIMESTER PREGNANCY; HUMAN; MAJOR CLINICAL STUDY; OUTCOMES RESEARCH; PATHOLOGY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RETROSPECTIVE STUDY; STATISTICAL SIGNIFICANCE; TRISOMY 21;

EID: 1942443780     PISSN: 03012115     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejogrb.2003.09.044     Document Type: Article

References (18)

1. Lin T.M., Halbert S.P., Kiefer D., Spellacy W., Gall S. Characterisation of four human pregnancy-associated plasma proteins. Am. J. Obstet. Gynecol. 118:1974;223-236.
2. Bischof P., Bruce D., Cunningham P., Klopper A. Measurement of pregnancy associated plasma protein A (PAPP-A). Clin. Chim. Acta. 95:1979;243-247.
3. Bischof P., Haenggeli L., Sizonenko M.T., Hermann W., Sizonenko P.C. Radioimmunoassay for the measurement of pregnancy associated plasma protein-A in humans. Biol. Reprod. 24:1981;1076-1081.
4. Hughes G, Bischof P, Wilson G, Klopper A. Assay of a placental protein to determine fetal risk. BMJ 1980;8:671-3.
5. Spencer K., Souter V., Tul N., Snijders R., Nicolaides K.H. A screening for trisomy 21 at 10-14 weeks using foetal nuchal translucency, maternal serum free beta human chorionic gonadotropin and pregnancy associated plasma protein A. Ultrasound Obstet. Gynecol. 13:1999;231-237.
6. Wald N.J., Mackshaw A.K. Combining ultrasound and biochemistry in first-trimester screening for Down's syndrome. Prenat. Diagn. 17:1997;821-829.
7. Macintosh M.C., Iles R., Teisner B., Sharma K., Chard T., Grudzinskas J.G.et al. Maternal serum human chorionic gonadotropin and pregnancy associated plasma protein A, markers for foetal Down syndrome at 8-14 weeks. Prenat. Diagn. 14:1994;203-208.
8. Ong C.Y.T., Liao A.W., Spencer K., Munim S.H., Nicolaides K.H. First trimester maternal serum free β human chorionic gonadotropin and pregnancy associated plasma protein A as predictors of pregnancy complications. Br. J. Obstet. Gynaecol. 107:2000;1265-1270.
9. World Health Organisation Expert Committee on Diabetes Mellitus. Technical Report Series 646. Geneva: WHO; 1980. p. 8.
10. Cicero S., Bindra R., Rembouskos G., Spencer K., Nicolaides K.H. Integrated ultrasound and biochemical screening for trisomy 21 using foetal nuchal translucency, absent nasal bone, free β hCG and PAPP-A at 11 to 14 weeks. Prenat. Diagn. 23:2003;306-310.
11. Yaron Y., Heifetz S., Ochshorn Y., Lehavi O., Orr-Urtreger A. Decreased first trimester PAPP-a is a predictor of adverse pregnancy outcome. Prenat. Diagn. 22:2002;778-782.
12. Smith G.C., Stenhouse E.J., Crossley J.A., Cameron A.D., Connor J.M. Early pregnancy levels of pregnancy-associated plasma protein-A and the risk of intrauterine growth restriction, premature birth, preeclampsia and stillbirth. J. Clin. Endocrinol. Metab. 87:2002;1762-1767.
13. Westergaard J.G., Sinosich M.J., Bugge M., Madsen L.T., Teisner B., Grudzinskas J.G.et al. Pregnancy-associated plasma protein-A in prediction of early pregnancy failure. Am. J. Obstet. Gynecol. 145:1983;67-69.
14. Ruge S.A., Pedersen J.F., Sorensen S., Lange A.P. Can pregnancy-associated plasma protein-A predict the outcome of pregnancy in women with threatened abortion and confirmed fetal viability. Acta Obstet. Gynecol. Scand. 69:1990;589-595.
15. Morssink P.L., Kornman L.H., Hallahan T.W., Kloosterman M.D., Beekhuis J.R., de Wolf B.T.H.M., Mantingh A. Maternal serum levels of free β hCG and PAPP-A in the first trimester of pregnancy are not associated with subsequent foetal growth retardation or pre-term delivery. Prenat. Diagn. 18:1998;147-152.
16. Monget P., Mazerbourg S., Delpuech T., Maurel M.C., Maniere S., Zapf J.et al. Pregnancy-associated plasma protein-A is involved in insulin-like growth factor binding protein-2 (IGFBP-2) proteolytic degradation in bovine and porcine preovulatory follicles: identification of cleavage site and characterisation of IGFBP-2 degradation. Biol. Reprod. 68:2003;77-86.
17. Summers A.M., Huang T., Meier C., Wyatt P.R. The implications of a false positive second-trimester serum screen for Down syndrome. Obstet. Gynecol. 101:2003;1301-1306.
18. Greenwolg N., Jauniaux E., Gulbis B., Hempstock J., Gervy C., Burton G.J. Relationship among maternal serum endocrinology, placental karyotype, and intervillous circulation in early pregnancy failure. Fertil. Steril. 79:2003;1373-1379.