Effect of C677T Methylenetetrahydrofolate Reductase Gene Polymorphism on Plasma Homocysteine Levels in Ethnic Groups

Physiological Research

Volumn 53, Issue 2, 2004, Pages 215-218

  Gasparovic J ^a,e   Raslova K ^a   Basistova Z ^a   Zacharova M ^a   Wsolova L ^a   Avdicova M ^b   Blazicek P ^c   Lietava, J ^d   Sivakova D ^a  

^a Physics and Informatics   (Slovakia)

^b State Institute of Health   (Slovakia)

^c Military Hospital   (Slovakia)

^d Dept of Medicine Teaching Hospital ^*  (Slovakia)

^e INST OF PREV AND CLINICAL MEDICINE   (Slovakia)

Author keywords

C677T methylenetetrahydrofolate reductase polymorphism; Ethnic groups; Homocysteine; Slovak Caucasians; Slovak Romanies

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); HOMOCYSTEINE;

ADULT; AGED; AMINO ACID BLOOD LEVEL; ARTICLE; CARDIOVASCULAR RISK; CONTROLLED STUDY; DNA POLYMORPHISM; ETHNOLOGY; FEMALE; GENE; GENE FUNCTION; GENOTYPE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HOMOZYGOSITY; HUMAN; MALE; NORMAL HUMAN; POLYMERASE CHAIN REACTION; RISK FACTOR; SAMPLING; SLOVAKIA; STATISTICAL SIGNIFICANCE;

ADULT; BODY HEIGHT; BODY MASS INDEX; BODY WEIGHT; ETHNIC GROUPS; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENE FREQUENCY; GENOTYPE; GYPSIES; HEMATOCRIT; HOMOCYSTEINE; HUMANS; MALE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MIDDLE AGED; POLYMORPHISM, GENETIC; SEX FACTORS; SLOVAKIA; WAIST-HIP RATIO;

EID: 1942438624     PISSN: 08628408     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. AVDIČOVÁ M, EGNEROVÁ A, HRUBÁ F: Evaluation of the CINDI Program in Slovakia. Covering Risk Factors and Control of Hypertension 1992-2000. Ministry of Health of Slovak Republic, State Institute of Public Health of Banská Bystrica in collaboration with WHO Regional Office for Europe, 2000, 66 p.
2. BELKOVETS AV, KURILOVICH SA, AGARWAL DP: Methylenetetrahydrofolate reductase (MTHFR). Incidence of the C677T mutation in a Siberian female population. Anthrop Anz 1: 19-25, 2001.
3. BOUCHARD C, PERUSSE L, LEBLANC C, TREMBLAY A, THERIALULT G: Inheritance of the amount and distribution of human body fat. Int J Obes 12: 205-215, 1988.
4. CAPPUCCIO FP, BELL R, PERRY IJ, GILG J, UELAND PM, REFSUM H, SAGNELLA GA, JEFFERY S, COOK DG: Homocysteine levels in men and women of different ethnic and cultural background living in England. Atherosclerosis 164: 95-102, 2002.
5. FROSST P, BLOM HJ, MILOS R, GOYETTE P, SHEPPARD CA, MATHEWS RG, BOERS GHJ, den HEIJER M, KLUIJTMANS LAJ, VAN DEN HEUVEL I, ROZEN R: A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet 10: 111-113, 1995.
6. GUDNASON V, STANSBIE D, SCOTT J, BOWRON A, NICAUD V, HUMPHRIES S: C677T polymorphism in MTHFR: its frequency and impact on plasma homocysteine concentration in different European populations. Atherosclerosis 136: 347-354, 1998.
7. LYNCH J, KAPLAN GA, SALONEN R, COHEN RD, SALONEN JT: Socioeconomic status and carotid atherosclerosis. Circulation 92: 1786-1792, 1995.
8. MASTANA SS, PAPIHA SS: Origin of the Romany gypsies - genetic evidence. Z Morphol Anthropol 79: 43-51, 1992.
9. RAŠLOVÁ K, SMOLKOVÁ B, VOHNOUT B, GAŠPAROVIČ J, FROLICH JJ: Risk factors for atherosclerosis in survivors of myocardial infarction and their spouses: comparison to controls without personal and family history of atherosclerosis. Metabolism 50: 24-29, 2001.
10. ROWLEY KG, SU Q, CINCOTTA M, SKINNER M, PINDAN B, WHITE GA, O'DEA K: Improvements in circulating cholesterol, antioxidants, and homocysteine after dietary intervention in an Australian aboriginal community. Am J Clin Nutr 74: 442-448, 2001.
11. SCHNEIDER, JA, REES, DC, LIU, YT, CLEGG, JB: Worldwide distribution of a common methyleneterahydrofolate reductase polymorphism mutation. Am J Hum Genet 62: 1258-1260, 1998.
12. TOBOREK T, HENNEIG B: Dietary methionine imbalance, endothelial cell dysfunction and atherosclerosis. Nutr Res 16: 1251-1266, 1996.
13. UELAND PM, REFSUM H, STABLER SP, MALINOW MR, ANDERSSON A, ALLEN RH: Total homocysteine in plasma or serum: methods and clinical applications. Clin Chent 39: 1764-1779, 1993.