The in vivo cardiovascular effects of box jellyfish Chironex fleckeri venom in rats: Efficacy of pre-treatment with antivenom, verapamil and magnesium sulphate

Toxicon

Volumn 43, Issue 6, 2004, Pages 685-690

  Ramasamy, Sharmaine ^a   Isbister, Geoffrey K ^a,b   Seymour, Jamie E ^c   Hodgson, Wayne C ^a  

^a MONASH UNIVERSITY   (Australia)

^b UNIVERSITY OF NEWCASTLE   (Australia)

^c JAMES COOK UNIVERSITY   (Australia)

Author keywords

Antivenom; Box jellyfish; Cardiovascular; Chironex fleckeri; Magnesium; Venom; Verapamil

Indexed keywords

MAGNESIUM SULFATE; SNAKE VENOM; VERAPAMIL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ARTIFICIAL VENTILATION; CARDIOVASCULAR EFFECT; HYPERTENSION; HYPOTENSION; MALE; NONHUMAN; PRESSOR RESPONSE; PRIORITY JOURNAL; PROPHYLAXIS; RAT; SHOCK;

ANIMALS; ANTIVENINS; CARDIOVASCULAR SYSTEM; CNIDARIAN VENOMS; CUBOZOA; INFUSIONS, INTRAVENOUS; MAGNESIUM SULFATE; MALE; RATS; RATS, SPRAGUE-DAWLEY; VERAPAMIL;

ANIMALIA; CHIRONEX FLECKERI; CUBOZOA; SCYPHOZOA;

EID: 1942436844     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxicon.2004.02.024     Document Type: Article

References (27)

1. Bailey P.M., Little M., Jelinek G.A., Wilce J.A. Jellyfish envenoming syndromes: unknown toxic mechanisms and unproven therapies. Med. J. Aust. 178:2003;34-37.
2. Bloom D.A., Burnett J.W., Alderslade P. Partial purification of box jellyfish (Chironex fleckeri) nematocyst venom isolated at the beachside. Toxicon. 36:1998;1075-1085.
3. Burnett J.W., Calton G.J. Response of the box-jellyfish (Chironex fleckeri) cardiotoxin to intravenous administration of verapamil. Med. J. Aust. 2:1983;192-194.
4. Carrette T., Seymour J. A rapid and repeatable method for venom extraction from cnidarians. Toxicon. 2004;. in press.
5. 2+ levels by Scorpaenidae venoms. Toxicon. 41:2003;679-689.
6. Corkeron M.A. Magnesium infusion to treat Irukandji syndrome. Med. J. Aust. 178:2003;411.
7. Currie B. Clinical implications of research on the box-jellyfish Chironex fleckeri. Toxicon. 32:1994;1305-1313.
8. Currie B.J. Marine antivenoms. J. Toxicol. Clin. Toxicol. 41:2003;301-308.
9. Ehrenberg A., Helbig J. Influence of magnesium aspartate hydrochloride on transportation and slaughtering stress in pigs. Golf S., Dralle D., Vecchiet L. Magnesium. 1994;385-394 John Libbey, London.
10. Endean R., Henderson L. Further studies of toxic material from nematocysts of the cubomedusan Chironex fleckeri Southcott. Toxicon. 7:1969;303-314.
11. Endean R., Noble M. Toxic material from the tentacles of the cubomedusan Chironex fleckeri. Toxicon. 9:1971;255-264.
12. Endean R., Sizemore D.J. The effectiveness of antivenom in countering the actions of box-jellyfish (Chironex fleckeri) nematocyst toxins in mice. Toxicon. 26:1988;425-431.
13. Fawcett W.J., Haxby E.J., Male D.A. Magnesium: physiology and pharmacology. Br. J. Anaesth. 83:1999;302-320.
14. Fenner P.J., Williamson J.A., Blenkin J.A. Successful use of Chironex antivenom by members of the Queensland Ambulance Transport Brigade. Med. J. Aust. 151:1989;708-710.
15. Freeman S.E., Turner R.J. Cardiovascular effects of toxins isolated from the cnidarian Chironex fleckeri Southcott. Br. J. Pharmacol. 41:1971;154-166.
16. Harvey A. Editorial: testing of natural remedies for natural toxins. Toxicon. 41:2003;939.
17. Huynh T.T., Seymour J., Pereira P., Mulcahy R., Cullen P., Carrette T., Little M. Severity of Irukandji syndrome and nematocyst identification from skin scrapings. Med. J. Aust. 178:2003;38-41.
18. James M.F. Use of magnesium sulphate in the anaesthetic management of phaeochromocytoma: a review of 17 anaesthetics. Br. J. Anaesth. 62:1989;616-623.
19. Keen T.E. Recent investigations on sea-wasp stingings in Australia. Med. J. Aust. 1:1970;266-270.
20. Maguire E.J. Chironex fleckeri ('sea wasp') sting. Med. J. Aust. 2:1968;1137-1138.
21. Mustafa M.R., White E., Hongo K., Othman I., Orchard C.H. The mechanism underlying the cardiotoxic effect of the toxin from the jellyfish Chironex fleckeri. Toxicol. Appl. Pharmacol. 133:1995;196-206.
22. Nagai H., Takuwa K., Nakao M., Ito E., Miyake M., Noda M., Nakajima T. Novel proteinaceous toxins from the box jellyfish (sea wasp) Carybdea rastoni. Biochem. Biophys. Res. Commun. 275:2000;582-588.
23. O'Reilly G.M., Isbister G.K., Lawrie P.M., Treston G.T., Currie B.J. Prospective study of jellyfish stings from tropical Australia, including the major box jellyfish Chironex fleckeri. Med. J. Aust. 175:2001;652-655.
24. Ramasamy S., Isbister G.K., Seymour J.E., Hodgson W.C. The in vitro effects of two chirodropid (Chironex fleckeri and Chiropsalmus sp.) venoms: efficacy of box jellyfish antivenom. Toxicon. 41:2003;703-711.
25. Tibballs J., Williams D., Sutherland S.K. The effects of antivenom and verapamil on the haemodynamic actions of Chironex fleckeri (box jellyfish) venom. Anaesth. Intensive Care. 26:1998;40-45.
26. Williamson J.A., Le Ray L.E., Wohlfahrt M., Fenner P.J. Acute management of serious envenomation by box-jellyfish (Chironex fleckeri). Med. J. Aust. 141:1984;851-853.
27. Wiltshire C.J., Sutherland S.K., Fenner P.J., Young A.R. Optimization and preliminary characterization of venom isolated from 3 medically important jellyfish: the box (Chironex fleckeri), Irukandji (Carukia barnesi), and blubber (Catostylus mosaicus) jellyfish. Wilderness Environ. Med. 11:2000;241-250.