A unifying concept of seizure onset and termination

Medical Hypotheses

Volumn 62, Issue 5, 2004, Pages 740-745

  Doman, Glenn ^a   Pelligra, Ralph ^a,b  

^a Institutes Achievement Hum P   (United States)

^b NASA HEADQUARTERS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; ION CHANNEL;

BRAIN CIRCULATION; BRAIN INJURY; CELL FUNCTION; ELECTRIC SHOCK; ENERGY YIELD; HOMEOSTASIS; HUMAN; HYPOXIA; ION TRANSPORT; MEDICAL LITERATURE; MITOCHONDRIAL RESPIRATION; MODEL; NERVE CELL; NERVE EXCITABILITY; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REVIEW; SEIZURE; SPREADING CORTICAL DEPRESSION;

EID: 1942436063     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2003.10.020     Document Type: Article

References (28)

1. Fay T. The other side of a fit. Amer J Psychiatry 1942;39:196-200.
2. Doman G, Pelligra R. Ictogenesis: the origin of seizures in humans. A new look at an old theory. Med Hypoth 2003;60(1):129-32.
3. Lodish HF, Berk A, Zipursky S, Masudaira P, et al. editors. Nerve Cells. In: Molecular cell biology, 4th ed. New York: W.H. Freeman & Co; 1999. p. 647, 917 [Chapter 21].
4. Futamachi KJ, Mutani R, Prince DA. Potassium activity in rabbit cortex. Brain Res 1974;75:5-25.
5. + changes during epileptiform discharges in the immature cortex. Dev Brain Res 1987;36:299-303.
6. Traynelis SF, Dingledine R. Potassium induced spontaneous electrographic seizures in the rat hippocampal slice. J Neurophysiol 1988;59:259-76.
7. Rutecki PA, Lebeda F, Johnston D. Epileptiform activity induced by changes in extracellular potassium in hippocampus. J Neurophysiol 1985;54:1363-74.
8. Haglund NM, Schwartskroin PA. Role of Na-K pump potassium regulation and IPSPs in seizures and spreading depression in immature rabbit hippocampal slices. J Neurophysiol 1990;63(2):225-39.
9. Mody I. Ion channels in epilepsy. Int Rev Neurobiol 1998;42:199-225.
10. Schroeder BC, Kubisch C, Stein V, Jentsch TJ. Moderate loss of function of cyclic AMP-modulated KCNQ2/KCNQ3 Kchannels causes epilepsy. Nature 1998;396:687-90.
11. Delgado-Escueta AV, Medina MT, Serratosa JM, et al. Mapping and positional cloning of common idiopathic generalized epilepsies: juvenile myoclonic epilepsy and childhood absence epilepsy. In: Olsen RW, Porter RJ, editors. Jasper's basic mechanisms of the epilepsies. 3rd ed. Advances in neurology, vol. 79. Philadelphia, PA: Lippincott, Williams & Wikins; 1999. p. 351-74.
12. Patel AJ, Lauritzen I, Lazdunskf M, Honore E. Disruption of mitochondrial respiration inhibits volume-regulated anion channels and provokes neuronal cell swelling. J Neurosci 1998;18(9):3117-23.
13. James AM, Wei YH, Pang CY, Murphy MP. Altered mitochondrial function in fibroblasts containing MELAS or MERRF mitochondrial DNA mutations. J Biochem 1996;318:401-7.
14. Brian JE, Faraci FM, Heistad DD. Recent insights into the regulation of cerebral circulation. Clin Exp Pharmacol Physiol 1996;23(6-7):449-57.
15. Leao AAP. Spreading depression of activity in the cerebral cortex. J Neurophsyiol 1944;7:359-89.
16. Guillon B, Duncan R, Biraben A, et al. Correlation between interictal regional ceebral blood flow and depth-recorded interictal spiking in temporal lobe epilepsy. Epilepsia 1998;39(1):67-76.
17. De Simone R, Silvestrini M, Marlani MG, Curatolo P. Changes in cerebral blood flow velocities during childhood absence seizures. Pediatr Neurol 1998;18(2):132-5.
18. Hwang PA, Otsubo H, Koo BK, et al. Infantile spasms: cerebral blood flow abnormalities correlate with EEG, neuroimaging and pathologic findings. Pediatr Neurol 1996;14(3):220-5.
19. Okuchi K, Nagata K, Otsuka H, et al. Regional cerebral blood flow after status epilepticus. Keio J Med 2000;40(S-1):A75-6.
20. Karagol U, Deda G, Uysal S, et al. Cerebral blood flow abnormalities in symptomatic West syndrome: a single photon emission computed tomography study. Pediatr Int 2001;43(1):66-70.
21. Sakagami M, Takahashi Y, Matsuoka H, et al. A case of early-onset benign occipal seizure susceptibility syndrome: decreased cerebral blood flow in the occipiatal region detected by interictal single photon emission computed tomography, corresponding to the epileptogenic focus. Brain Develop 2001;23:4217-30.
22. Weinand ME, Labiner DM, Ahern GL. Temporal lobe seizure interhemispheric propagation time depends on nonepileptic cortical cerebral blood flow. Epilepsy Res 2001;44(1):33-9.
23. Duncan JS. Imaging and epillepsy. Brain 1997;120:339-77.
24. Reid KH, Marrannes R, Waliquier A. Spreading depression and central nervous system pharmacology. J Pharmocol Meth 1988;19:1-21.
25. Amery WK. Brain hypoxia: the turning point In the genesis of the migraine attack? Cephalalgia 1982;2:83-109.
26. DeLuca B, Shibata M, Brozek G, Bures J. Faciliation of Leao's spreading depression by a pyropyrimidine derivative. Neuropharmacology 1975;14:537-45.
27. Bures J, Buresova O, Krivanek J. The mechanism and applications of Leao's spreading depression of electroencephalographic activity. New York: Academic Press; 1974.
28. Willmorr LJ, Wheless JW. Epilepsy. In: Dale DC, Federman DD, editors. Scientific American Medicine. New York, NY: WebMD corporation; 2001.