Segregation analysis indicates a major gene in the control of interleukine- 5 production in humans infected with Schistosoma mansoni

American Journal of Human Genetics

Volumn 59, Issue 2, 1996, Pages 453-461

  Rodrigues Jr , Virmondes ^a,b   Abel, Laurent ^c   Piper, Karen ^a   Dessein, Alain J ^a  

^a INSERM   (France)

^b FEDERAL UNIVERSITY OF TRIÂNGULO MINEIRO   (Brazil)

^c PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 5; MONOCLONAL ANTIBODY; PHYTOHEMAGGLUTININ;

ADOLESCENT; ADULT; ALLERGIC DISEASE; ARTICLE; BRAZIL; CHILD; FEMALE; GENE FREQUENCY; GENETIC LINKAGE; HEREDITY; HUMAN; HUMAN CELL; IMMUNE RESPONSE; INFANT; INFECTION SENSITIVITY; MAJOR CLINICAL STUDY; MALE; MONONUCLEAR CELL; PARASITOSIS; PHENOTYPE; PRIORITY JOURNAL; SCHISTOSOMA MANSONI; SEGREGATION ANALYSIS;

ADOLESCENT; ADULT; AGE FACTORS; BRAZIL; CELLS, CULTURED; CHILD; CHILD, PRESCHOOL; HUMANS; INTERLEUKIN-5; LEUKOCYTES, MONONUCLEAR; LINEAR MODELS; LOD SCORE; MEIOSIS; MIDDLE AGED; SCHISTOSOMIASIS MANSONI; SEX FACTORS; VARIATION (GENETICS);

EID: 19244362963     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (5)

1. Abel L, Demenais F, Prata A, Souza AE, Dessein A (1991) Evidence for the segregation of a major gene in human susceptibility/resistance to infection by Schistosoma mansoni. Am J Hum Genet 48:959-970
2. Bonney GE (1984) On the statistical determination of major gene mechanisms in continuous human traits: regressive models. Am J Med Genet 18:731-749
3. (1986) Regressive logistic models for familial diseases and other binary traits. Biometrics 42:611-625
4. Bonney GE, Lathrop GM, Lalouel J-M (1988) Combined linkage and segegation analysis using regressive models. Am J Hum Genet 43:29-37
5. Broide DH, Paine MM, Firestein GS (1992) Eosinophils express interleukin 5 and granulocyte macrophage-colony-simulating factor mRNA at sites of allergic inflammation in asthmatics. J Clin Invest 90:1414-1424