Species differences in the formation of DA-8164 after intravenous and/ or oral administration of DA-8159, a new erectogenic, to mice, rats, rabbits, dogs and humans

Biopharmaceutics and Drug Disposition

Volumn 26, Issue 4, 2005, Pages 161-166

  Shim, Hyun J ^a,b   Kim, Yu C ^a   Lee, Joo H ^a   Park, Kyung J ^b   Kwon, Jong W ^b   Kim, Won B ^b   Lee, Myung G ^a  

^a Seoul National University   (South Korea)

^b Dong A Pharmaceutical Company   (South Korea)

Author keywords

DA 8159 and DA 8164; Dogs; Humans; Mice; Rabbits; Rats; Species difference

Indexed keywords

5 [2 PROPYLOXY 5 (AMINOSULFONYL)PHENYL] 1 METHYL 3 PROPYL 1,6 DIHYDRO 7H PYRAZOLO[4,3 D]PYRIMIDINE 7 ONE; CYCLIC GMP PHOSPHODIESTERASE; CYTOCHROME P450 ISOENZYME; DA 8164; DRUG METABOLITE; PHOSPHODIESTERASE V INHIBITOR; UDENAFIL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DOG; DRUG ADMINISTRATION ROUTE; DRUG BLOOD LEVEL; DRUG DOSE REGIMEN; ENZYME ACTIVITY; FIRST PASS EFFECT; GASTROINTESTINAL TRACT FUNCTION; HUMAN; HUMAN EXPERIMENT; HUMAN VERSUS ANIMAL COMPARISON; LIVER METABOLISM; MALE; MOUSE; NONHUMAN; NORMAL HUMAN; RABBIT; RAT; SPECIES COMPARISON; SPECIES DIFFERENCE;

ADMINISTRATION, ORAL; ANIMALS; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOGS; HUMANS; INFUSIONS, INTRAVENOUS; MALE; MICE; MICE, INBRED ICR; PENILE ERECTION; PYRIMIDINES; RABBITS; RATS; RATS, SPRAGUE-DAWLEY; SPECIES SPECIFICITY;

EID: 19144369136     PISSN: 01422782     EISSN: None     Source Type: Journal    
DOI: 10.1002/bdd.444     Document Type: Article

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